Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-?-catenin signaling.
Zhang B, Li M, McDonald T, Holyoake TL, Moon RT, Campana D, Shultz L, Bhatia R. Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-?-catenin signaling. Blood. 2013 Mar 07; 121(10):1824-38.
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Animals
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Apoptosis
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beta Catenin
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Biomarkers, Tumor
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Blotting, Western
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Bone Marrow
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Cadherins
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Cell Cycle
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Cell Proliferation
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Drug Resistance, Neoplasm
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Fusion Proteins, bcr-abl
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Gene Expression Profiling
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Humans
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive
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Mice
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Mice, Nude
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Neoplastic Stem Cells
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Oligonucleotide Array Sequence Analysis
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Phosphorylation
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Protein Kinase Inhibitors
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Real-Time Polymerase Chain Reaction
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Reverse Transcriptase Polymerase Chain Reaction
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RNA, Messenger
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Tumor Cells, Cultured
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Tumor Microenvironment