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Ildar Gainetdinov PhD

TitleAdjunct Assistant Professor
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressNew York University
29 Washington Place
New York NY 10003
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute


    Collapse Biography 
    Collapse education and training
    Moscow State University, Moscow, , Russian FederationBABiochemistry
    Moscow State University, Moscow, , Russian FederationMSBiochemistry
    Russian Academy of Sciences, Moscow, , Russian FederationPHDMolecular Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kraus C, Wang J, Zheng H, Broderick J, Ajaykumar N, Zamani M, Yang M, Cecchini K, Liang SQ, Kolumba O, Chase K, Lee J, Xue W, Sontheimer EJ, Gainetdinov I. Absolute quantification of mammalian microRNAs for therapeutic RNA cleavage and detargeting. RNA. 2025 Jul 16; 31(8):1081-1090. PMID: 40436630.
      Citations:    
    2. Lee SK, Shen W, Wen W, Joo Y, Xue Y, Park A, Qiang A, Su S, Zhang T, Zhang M, Fan J, Zhang Y, De S, Gainetdinov I, Sharov A, Maragkakis M, Wang W. Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development. Cell Rep. 2025 Apr 22; 44(4):115495. PMID: 40184251.
      Citations:    
    3. Cecchini K, Ajaykumar N, Bagci A, Zamore PD, Gainetdinov I. Mouse Pachytene piRNAs Cleave Hundreds of Transcripts, But Alter the Steady-State Abundance of Only a Minority of Targets. bioRxiv. 2024 Nov 03. PMID: 39554027.
      Citations:    
    4. Venkei ZG, Gainetdinov I, Bagci A, Starostik MR, Choi CP, Fingerhut JM, Chen P, Balsara C, Whitfield TW, Bell GW, Feng S, Jacobsen SE, Aravin AA, Kim JK, Zamore PD, Yamashita YM. A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila. Nat Cell Biol. 2023 10; 25(10):1495-1505. PMID: 37723298.
      Citations:    Fields:    Translation:Animals
    5. Gainetdinov I, Vega-Badillo J, Cecchini K, Bagci A, Colpan C, De D, Bailey S, Arif A, Wu PH, MacRae IJ, Zamore PD. Relaxed targeting rules help PIWI proteins silence transposons. Nature. 2023 07; 619(7969):394-402. PMID: 37344600.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Cecchini K, Biasini A, Yu T, S?flund M, Mou H, Arif A, Eghbali A, Colpan C, Gainetdinov I, de Rooij DG, Weng Z, Zamore PD, ?zata DM. The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice. Reproduction. 2023 02 01; 165(2):183-196. PMID: 36395073.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Arif A, Bailey S, Izumi N, Anzelon TA, Ozata DM, Andersson C, Gainetdinov I, MacRae IJ, Tomari Y, Zamore PD. GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins. Nature. 2022 08; 608(7923):618-625. PMID: 35772669.
      Citations: 11     Fields:    Translation:AnimalsCells
    8. Gainetdinov I, Colpan C, Cecchini K, Arif A, Jouravleva K, Albosta P, Vega-Badillo J, Lee Y, ?zata DM, Zamore PD. Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability. Mol Cell. 2021 12 02; 81(23):4826-4842.e8. PMID: 34626567.
      Citations: 12     Fields:    Translation:AnimalsCells
    9. Jolly SM, Gainetdinov I, Jouravleva K, Zhang H, Strittmatter L, Bailey SM, Hendricks GM, Dhabaria A, Ueberheide B, Zamore PD. Thermus thermophilus Argonaute Functions in the Completion of DNA Replication. Cell. 2020 09 17; 182(6):1545-1559.e18. PMID: 32846159.
      Citations: 34     Fields:    Translation:Cells
    10. Wu PH, Fu Y, Cecchini K, ?zata DM, Arif A, Yu T, Colpan C, Gainetdinov I, Weng Z, Zamore PD. The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility. Nat Genet. 2020 07; 52(7):728-739. PMID: 32601478.
      Citations: 58     Fields:    Translation:AnimalsCells
    11. ?zata DM, Yu T, Mou H, Gainetdinov I, Colpan C, Cecchini K, Kaymaz Y, Wu PH, Fan K, Kucukural A, Weng Z, Zamore PD. Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans. Nat Ecol Evol. 2020 01; 4(1):156-168. PMID: 31900453.
      Citations: 37     Fields:    Translation:HumansAnimals
    12. Ge DT, Wang W, Tipping C, Gainetdinov I, Weng Z, Zamore PD. The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria. Mol Cell. 2019 06 06; 74(5):982-995.e6. PMID: 31076285.
      Citations: 35     Fields:    Translation:AnimalsCells
    13. Ozata DM, Gainetdinov I, Zoch A, O'Carroll D, Zamore PD. PIWI-interacting RNAs: small RNAs with big functions. Nat Rev Genet. 2019 02; 20(2):89-108. PMID: 30446728.
      Citations: 420     Fields:    Translation:HumansAnimalsCells
    14. Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-P?rez JA, Sontheimer EJ. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In?Vivo Genome Editing. Mol Cell. 2019 Feb 21; 73(4):714-726.e4. PMID: 30581144.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    15. Chang TH, Mattei E, Gainetdinov I, Colpan C, Weng Z, Zamore PD. Maelstrom Represses Canonical Polymerase II Transcription within Bi-directional piRNA Clusters in Drosophila melanogaster. Mol Cell. 2019 01 17; 73(2):291-303.e6. PMID: 30527661.
      Citations: 18     Fields:    Translation:AnimalsCells
    16. Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. mBio. 2018 12 04; 9(6). PMID: 30514786.
      Citations: 43     Fields:    Translation:HumansCells
    17. Gainetdinov I, Colpan C, Arif A, Cecchini K, Zamore PD. A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. Mol Cell. 2018 09 06; 71(5):775-790.e5. PMID: 30193099.
      Citations: 89     Fields:    Translation:AnimalsCells
    18. Gainetdinov IV, Skvortsova YV, Kondratieva SA, Klimov A, Tryakin AA, Azhikina TL. Assessment of piRNA biogenesis and function in testicular germ cell tumors and their precursor germ cell neoplasia in situ. BMC Cancer. 2018 01 04; 18(1):20. PMID: 29301509.
      Citations:    
    19. Gainetdinov I, Skvortsova Y, Kondratieva S, Funikov S, Azhikina T. Two modes of targeting transposable elements by piRNA pathway in human testis. RNA. 2017 11; 23(11):1614-1625. PMID: 28842508.
      Citations:    
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