Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.

Descriptor ID	D020138
MeSH Number(s)	C16.320.565.100.480 C18.452.603.378 C18.452.648.100.480 C18.654.521.500.133.699.418
Concept/Terms	Hyperhomocysteinemia Hyperhomocysteinemia Hyperhomocysteinemias

Below are MeSH descriptors whose meaning is more general than "Hyperhomocysteinemia".

Below are MeSH descriptors whose meaning is related to "Hyperhomocysteinemia".

Below are MeSH descriptors whose meaning is more specific than "Hyperhomocysteinemia".