"Folic Acid Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)
| Descriptor ID |
D005494
|
| MeSH Number(s) |
C18.654.521.500.133.699.308
|
| Concept/Terms |
Folic Acid Deficiency- Folic Acid Deficiency
- Deficiency, Folic Acid
- Acid Deficiencies, Folic
- Acid Deficiency, Folic
- Deficiencies, Folic Acid
- Folic Acid Deficiencies
|
Below are MeSH descriptors whose meaning is more general than "Folic Acid Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Folic Acid Deficiency".
This graph shows the total number of publications written about "Folic Acid Deficiency" by people in this website by year, and whether "Folic Acid Deficiency" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 1 | 2 |
| 2003 | 2 | 1 | 3 |
| 2004 | 2 | 1 | 3 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Folic Acid Deficiency" by people in Profiles.
-
Philip D, Buch A, Moorthy D, Scott TM, Parnell LD, Lai CQ, Ordov?s JM, Selhub J, Rosenberg IH, Tucker KL, Troen AM. Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults. Am J Clin Nutr. 2015 Nov; 102(5):1279-88.
-
Ye X, Lai CQ, Crott JW, Troen AM, Ordovas JM, Tucker KL. The folate hydrolase 1561C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosom Med. 2011 Jun; 73(5):385-92.
-
Chan A, Rogers E, Shea TB. Dietary deficiency in folate and vitamin E under conditions of oxidative stress increases phospho-tau levels: potentiation by ApoE4 and alleviation by S-adenosylmethionine. J Alzheimers Dis. 2009; 17(3):483-7.
-
Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005 Sep; 82(3):627-35.
-
Shea TB, Ortiz D, Rogers E. Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation. J Alzheimers Dis. 2004 Jun; 6(3):269-73.
-
Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell. 2004 Apr; 3(2):71-6.
-
Tchantchou F, Graves M, Ortiz D, Rogers E, Shea TB. Dietary supplementation with 3-deaza adenosine, N-acetyl cysteine, and S-adenosyl methionine provide neuroprotection against multiple consequences of vitamin deficiency and oxidative challenge: relevance to age-related neurodegeneration. Neuromolecular Med. 2004; 6(2-3):93-103.
-
Gao X, Yao M, McCrory MA, Ma G, Li Y, Roberts SB, Tucker KL. Dietary pattern is associated with homocysteine and B vitamin status in an urban Chinese population. J Nutr. 2003 Nov; 133(11):3636-42.
-
Ho PI, Ashline D, Dhitavat S, Ortiz D, Collins SC, Shea TB, Rogers E. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol Dis. 2003 Oct; 14(1):32-42.
-
Mihalick SM, Ortiz D, Kumar R, Rogers E, Shea TB. Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E. Neuromolecular Med. 2003; 4(3):197-202.