Apolipoproteins E

"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.

Descriptor ID	D001057
MeSH Number(s)	D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
Concept/Terms	Apolipoproteins E Apolipoproteins E ApoE Apo E Apo-E Apolipoprotein E Isoproteins Apolipoprotein E Isoproteins Isoproteins, Apolipoprotein E Apo E Isoproteins Isoproteins, Apo E Apoproteins E Apoproteins E Apoprotein (E)

Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".

Chemicals and Drugs [D]
Lipids [D10]
Lipoproteins [D10.532]
Apolipoproteins [D10.532.091]
Apolipoproteins E [D10.532.091.500]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Apoproteins [D12.776.070]
Apolipoproteins [D12.776.070.400]
Apolipoproteins E [D12.776.070.400.500]
Lipoproteins [D12.776.521]
Apolipoproteins [D12.776.521.120]
Apolipoproteins E [D12.776.521.120.500]

Below are MeSH descriptors whose meaning is related to "Apolipoproteins E".

Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.

Bar chart showing 83 publications over 26 distinct years, with a maximum of 7 publications in 2011 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
1996	0	2	2
1999	2	3	5
2000	1	1	2
2001	1	0	1
2002	2	0	2
2003	2	1	3
2004	2	2	4
2005	2	1	3
2007	2	1	3
2008	1	1	2
2009	0	4	4
2010	1	2	3
2011	4	3	7
2012	3	0	3
2013	1	2	3
2014	0	2	2
2015	3	3	6
2016	0	4	4
2017	2	0	2
2018	1	2	3
2019	0	1	1
2021	0	2	2
2022	1	3	4
2023	0	4	4
2024	3	4	7

Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.

Soch J, Richter A, Kizilirmak JM, Sch?tze H, Ziegler G, Altenstein S, Brosseron F, Dechent P, Fliessbach K, Freiesleben SD, Glanz W, Gref D, Heneka MT, Hetzer S, Incesoy EI, Kilimann I, Kimmich O, Kleineidam L, Kuhn E, Laske C, Lohse A, L?sebrink F, Munk MH, Peters O, Preis L, Priller J, Ramirez A, Roeske S, Rostamzadeh A, Roy-Kluth N, Scheffler K, Schmid M, Schneider A, Spottke A, Spruth EJ, Teipel S, Wiltfang J, Jessen F, Wagner M, D?zel E, Schott BH. Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum. Brain. 2024 Nov 04; 147(11):3789-3803.

View in: PubMed
Lee WP, Choi SH, Shea MG, Cheng PL, Dombroski BA, Pitsillides AN, Heard-Costa NL, Wang H, Bulekova K, Kuzma AB, Leung YY, Farrell JJ, Lin H, Kunkle BW, Naj A, Blue EE, Nusetor F, Wang D, Boerwinkle E, Bush WS, Zhang X, De Jager PL, Dupuis J, Farrer LA, Fornage M, Martin E, Pericak-Vance M, Seshadri S, Wijsman EM, Wang LS, Schellenberg GD, Destefano AL, Haines JL, Peloso GM. Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project. Alzheimers Dement. 2024 Dec; 20(12):8470-8483.

View in: PubMed
Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024 Sep; 20(9):6590-6605.

View in: PubMed
Belgrad J, Tang Q, Hildebrand S, Summers A, Sapp E, Echeverria D, O'Reilly D, Luu E, Bramato B, Allen S, Cooper D, Alterman J, Yamada K, Aronin N, DiFiglia M, Khvorova A. A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Res. 2024 Jun 24; 52(11):6099-6113.

View in: PubMed
Ferguson CM, Godinho BMDC, Echeverria D, Hassler M, Vangjeli L, Sousa J, McHugh N, Alterman J, Hariharan V, Krishnamurthy PM, Watts J, Rogaev E, Khvorova A. A combinatorial approach for achieving CNS-selective RNAi. Nucleic Acids Res. 2024 May 22; 52(9):5273-5284.

View in: PubMed
Gustavson DE, Elman JA, Reynolds CA, Eyler LT, Fennema-Notestine C, Puckett OK, Panizzon MS, Gillespie NA, Neale MC, Lyons MJ, Franz CE, Kremen WS. Brain reserve in midlife is associated with executive function changes across 12 years. Neurobiol Aging. 2024 Sep; 141:113-120.

View in: PubMed
Ferguson CM, Hildebrand S, Godinho BMDC, Buchwald J, Echeverria D, Coles A, Grigorenko A, Vangjeli L, Sousa J, McHugh N, Hassler M, Santarelli F, Heneka MT, Rogaev E, Khvorova A. Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease. Alzheimers Dement. 2024 04; 20(4):2632-2652.

View in: PubMed
Waschkies KF, Soch J, Darna M, Richter A, Altenstein S, Beyle A, Brosseron F, Buchholz F, Butryn M, Dobisch L, Ewers M, Fliessbach K, Gabelin T, Glanz W, Goerss D, Gref D, Janowitz D, Kilimann I, Lohse A, Munk MH, Rauchmann BS, Rostamzadeh A, Roy N, Spruth EJ, Dechent P, Heneka MT, Hetzer S, Ramirez A, Scheffler K, Buerger K, Laske C, Perneczky R, Peters O, Priller J, Schneider A, Spottke A, Teipel S, D?zel E, Jessen F, Wiltfang J, Schott BH, Kizilirmak JM. Machine learning-based classification of Alzheimer's disease and its at-risk states using personality traits, anxiety, and depression. Int J Geriatr Psychiatry. 2023 10; 38(10):e6007.

View in: PubMed
Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, Lemere CA, Liddelow SA, Marcora E, Marsh SE, Nielsen HM, Petersen KK, Petersen M, Pi?a-Escudero SD, Qiu WQ, Quiroz YT, Reiman E, Sexton C, Tansey MG, Tcw J, Teunissen CE, Tijms BM, van der Kant R, Wallings R, Weninger SC, Wharton W, Wilcock DM, Wishard TJ, Worley SL, Zetterberg H, Carrillo MC. APOE and immunity: Research highlights. Alzheimers Dement. 2023 06; 19(6):2677-2696.

View in: PubMed
Heneka MT. ApoE4 makes microglia trem2bling. Neuron. 2023 01 18; 111(2):142-144.

View in: PubMed

People

Explore

Similar Concepts

Top Journals