Matrix Metalloproteinase 14
"Matrix Metalloproteinase 14" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN CONVERTASES such as FURIN. Matrix metalloproteinase 14 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of MATRIX METALLOPROTEINASE 15.
Descriptor ID |
D053511
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MeSH Number(s) |
D08.811.277.656.300.480.525.300.500 D08.811.277.656.675.374.525.300.500
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Concept/Terms |
Matrix Metalloproteinase 14- Matrix Metalloproteinase 14
- Metalloproteinase 14, Matrix
- Membrane-Type Matrix Metalloproteinase 1
- Membrane Type Matrix Metalloproteinase 1
- MMP-14 Metalloproteinase
- MMP 14 Metalloproteinase
- Metalloproteinase, MMP-14
- MT1-MMP
- MMP14 Metalloproteinase
- Metalloproteinase, MMP14
- MT-MMP-1
- MT1-Matrix Metalloproteinase
- MT1 Matrix Metalloproteinase
- Metalloproteinase, MT1-Matrix
- Membrane-Type 1 Matrix Metalloproteinase
- Membrane Type 1 Matrix Metalloproteinase
- MMP-X1 Protein
- MMP X1 Protein
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Below are MeSH descriptors whose meaning is more general than "Matrix Metalloproteinase 14".
Below are MeSH descriptors whose meaning is more specific than "Matrix Metalloproteinase 14".
This graph shows the total number of publications written about "Matrix Metalloproteinase 14" by people in this website by year, and whether "Matrix Metalloproteinase 14" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2009 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Matrix Metalloproteinase 14" by people in Profiles.
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Nandadasa S, Martin D, Deshpande G, Robert KL, Stack MS, Itoh Y, Apte SS. Degradomic Identification of Membrane Type 1-Matrix Metalloproteinase as an ADAMTS9 and ADAMTS20 Substrate. Mol Cell Proteomics. 2023 Jun; 22(6):100566.
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Kaimal R, Aljumaily R, Tressel SL, Pradhan RV, Covic L, Kuliopulos A, Zarwan C, Kim YB, Sharifi S, Agarwal A. Selective blockade of matrix metalloprotease-14 with a monoclonal antibody abrogates invasion, angiogenesis, and tumor growth in ovarian cancer. Cancer Res. 2013 Apr 15; 73(8):2457-2467.
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Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.
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Golubkov VS, Chekanov AV, Doxsey SJ, Strongin AY. Centrosomal pericentrin is a direct cleavage target of membrane type-1 matrix metalloproteinase in humans but not in mice: potential implications for tumorigenesis. J Biol Chem. 2005 Dec 23; 280(51):42237-41.