Genes, Lethal

"Genes, Lethal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.

Descriptor ID	D005804
MeSH Number(s)	G05.360.340.024.340.350
Concept/Terms	Genes, Lethal Genes, Lethal Gene, Lethal Lethal Gene Lethal Genes Alleles, Lethal Alleles, Lethal Allele, Lethal Lethal Allele Lethal Alleles

Below are MeSH descriptors whose meaning is more general than "Genes, Lethal".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Genes, Lethal [G05.360.340.024.340.350]

Below are MeSH descriptors whose meaning is more specific than "Genes, Lethal".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Genes, Lethal" by people in this website by year, and whether "Genes, Lethal" was a major or minor topic of these publications.

Bar chart showing 49 publications over 24 distinct years, with a maximum of 5 publications in 2003 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	3	3
1997	0	1	1
1998	0	2	2
1999	0	1	1
2000	0	3	3
2001	0	2	2
2002	0	3	3
2003	0	5	5
2004	1	1	2
2005	0	1	1
2006	0	2	2
2007	2	1	3
2008	0	1	1
2009	0	1	1
2010	0	2	2
2011	1	1	2
2012	1	2	3
2014	1	4	5
2016	0	1	1
2017	0	1	1
2019	1	0	1
2020	0	1	1
2022	1	1	2
2026	0	1	1

Below are the most recent publications written about "Genes, Lethal" by people in Profiles.

Guertin TM, Sisson C, Gargiulo RM, Macrorie O, Pease EL, Garth HE, Vriens J, De Clercq K, Mager J, Tremblay KD. Onset of embryonic and placental defects coincide in 19 of 22 novel mid-gestation lethal murine knockout lines. Development. 2026 May 15; 153(10).

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Cacheiro P, Westerberg CH, Mager J, Dickinson ME, Nutter LMJ, Mu?oz-Fuentes V, Hsu CW, Van den Veyver IB, Flenniken AM, McKerlie C, Murray SA, Teboul L, Heaney JD, Lloyd KCK, Lanoue L, Braun RE, White JK, Creighton AK, Laurin V, Guo R, Qu D, Wells S, Cleak J, Bunton-Stasyshyn R, Stewart M, Harrisson J, Mason J, Haseli Mashhadi H, Parkinson H, Mallon AM, Smedley D. Mendelian gene identification through mouse embryo viability screening. Genome Med. 2022 10 13; 14(1):119.

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Castillo DM, McCormick B, Kean CM, Natesan S, Barbash DA. Testing the Drosophila maternal haploid gene for functional divergence and a role in hybrid incompatibility. G3 (Bethesda). 2022 08 25; 12(9).

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Miao X, Sun T, Golan M, Mager J, Cui W. Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Mol Reprod Dev. 2020 11; 87(11):1152-1158.

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Cheong A, Degani R, Tremblay KD, Mager J. A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet. 2019 08 15; 28(16):2775-2784.

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Blum JA, Bonaccorsi S, Marzullo M, Palumbo V, Yamashita YM, Barbash DA, Gatti M. The Hybrid Incompatibility Genes Lhr and Hmr Are Required for Sister Chromatid Detachment During Anaphase but Not for Centromere Function. Genetics. 2017 12; 207(4):1457-1472.

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Shin J, Salameh JS, Richter JD. Impaired neurodevelopment by the low complexity domain of CPEB4 reveals a convergent pathway with neurodegeneration. Sci Rep. 2016 07 06; 6:29395.

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Dillon CP, Weinlich R, Rodriguez DA, Cripps JG, Quarato G, Gurung P, Verbist KC, Brewer TL, Llambi F, Gong YN, Janke LJ, Kelliher MA, Kanneganti TD, Green DR. RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014 May 22; 157(5):1189-202.

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Wei KH, Clark AG, Barbash DA. Limited gene misregulation is exacerbated by allele-specific upregulation in lethal hybrids between Drosophila melanogaster and Drosophila simulans. Mol Biol Evol. 2014 Jul; 31(7):1767-78.

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Satyaki PR, Cuykendall TN, Wei KH, Brideau NJ, Kwak H, Aruna S, Ferree PM, Ji S, Barbash DA. The Hmr and Lhr hybrid incompatibility genes suppress a broad range of heterochromatic repeats. PLoS Genet. 2014 Mar; 10(3):e1004240.

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