"Receptors, Somatotropin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins.
| Descriptor ID |
D011986
|
| MeSH Number(s) |
D12.776.543.750.750.555.770 D12.776.543.750.750.660.750
|
| Concept/Terms |
Receptors, Somatotropin- Receptors, Somatotropin
- Receptor, Growth Hormone
- Somatotropin Receptors
- Receptors, Growth Hormone
- Somatotropin Receptor
- Growth Hormone Receptor
- Hormone Receptor, Growth
- Growth Hormone Receptors
- Hormone Receptors, Growth
|
Below are MeSH descriptors whose meaning is more general than "Receptors, Somatotropin".
Below are MeSH descriptors whose meaning is more specific than "Receptors, Somatotropin".
This graph shows the total number of publications written about "Receptors, Somatotropin" by people in this website by year, and whether "Receptors, Somatotropin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptors, Somatotropin" by people in Profiles.
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Jara A, Liu X, Sim D, Benner CM, Duran-Ortiz S, Qian Y, List EO, Berryman DE, Kim JK, Kopchick JJ. Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice. Endocrinology. 2016 05; 157(5):1929-41.
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Schiffer C, Ultsch M, Walsh S, Somers W, de Vos AM, Kossiakoff A. Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites. J Mol Biol. 2002 Feb 15; 316(2):277-89.
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Reiter EO. Growth hormone: new ideas, recurring themes. Endocrine. 2001 Jun; 15(1):1-4.
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Gastier JM, Berg MA, Vesterhus P, Reiter EO, Francke U. Diverse deletions in the growth hormone receptor gene cause growth hormone insensitivity syndrome. Hum Mutat. 2000 Oct; 16(4):323-33.
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Wojcik J, Berg MA, Esposito N, Geffner ME, Sakati N, Reiter EO, Dower S, Francke U, Postel-Vinay MC, Finidori J. Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor. J Clin Endocrinol Metab. 1998 Dec; 83(12):4481-9.
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Leonard JL, Leonard DM, Shen Q, Farwell AP, Newburger PE. Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem. 1996 Jun 01; 61(3):410-9.
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Reiter E, Bonnet P, Sente B, Dombrowicz D, de Leval J, Closset J, Hennen G. Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats. Mol Cell Endocrinol. 1992 Oct; 88(1-3):77-87.