Fanconi Anemia

"Fanconi Anemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)

Descriptor ID	D005199
MeSH Number(s)	C15.378.071.085.080.280 C15.378.190.196.080.280 C16.320.077.280 C18.452.284.280
Concept/Terms	Fanconi Anemia Fanconi Anemia Anemias, Fanconi Fanconi Anemias Fanconi's Anemia Anemia, Fanconi's Fanconi Pancytopenia Fanconi Panmyelopathy Anemia, Fanconi Fanconi Hypoplastic Anemia

Below are MeSH descriptors whose meaning is more general than "Fanconi Anemia".

Diseases [C]
Hemic and Lymphatic Diseases [C15]
Hematologic Diseases [C15.378]
Anemia [C15.378.071]
Anemia, Aplastic [C15.378.071.085]
Anemia, Hypoplastic, Congenital [C15.378.071.085.080]
Fanconi Anemia [C15.378.071.085.080.280]
Bone Marrow Diseases [C15.378.190]
Anemia, Aplastic [C15.378.190.196]
Anemia, Hypoplastic, Congenital [C15.378.190.196.080]
Fanconi Anemia [C15.378.190.196.080.280]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Genetic Diseases, Inborn [C16.320]
Anemia, Hypoplastic, Congenital [C16.320.077]
Fanconi Anemia [C16.320.077.280]
Nutritional and Metabolic Diseases [C18]
Metabolic Diseases [C18.452]
DNA Repair-Deficiency Disorders [C18.452.284]
Fanconi Anemia [C18.452.284.280]

Below are MeSH descriptors whose meaning is related to "Fanconi Anemia".

Below are MeSH descriptors whose meaning is more specific than "Fanconi Anemia".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fanconi Anemia" by people in this website by year, and whether "Fanconi Anemia" was a major or minor topic of these publications.

Bar chart showing 15 publications over 10 distinct years, with a maximum of 3 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	1	0	1
2006	1	0	1
2007	1	1	2
2010	1	0	1
2011	2	1	3
2012	1	0	1
2013	2	0	2
2014	1	0	1
2017	1	0	1
2018	2	0	2

Below are the most recent publications written about "Fanconi Anemia" by people in Profiles.

Haworth KG, Ironside C, Ramirez MA, Weitz S, Beard BC, Schwartz JD, Adair JE, Kiem HP. Minimal conditioning in Fanconi anemia promotes multi-lineage marrow engraftment at 10-fold lower cell doses. J Gene Med. 2018 10; 20(10-11):e3050.

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Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP. Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A. Haematologica. 2018 11; 103(11):1806-1814.

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Adair JE, Sevilla J, Heredia CD, Becker PS, Kiem HP, Bueren J. Lessons Learned from Two Decades of Clinical Trial Experience in Gene Therapy for Fanconi Anemia. Curr Gene Ther. 2017; 16(5):338-348.

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Cantor SB, Brosh RM. What is wrong with Fanconi anemia cells? Cell Cycle. 2014; 13(24):3823-7.

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Hamilton JG, Hutson SP, Moser RP, Kobrin SC, Frohnmayer AE, Alter BP, Han PK. Sources of uncertainty and their association with medical decision making: exploring mechanisms in Fanconi anemia. Ann Behav Med. 2013 Oct; 46(2):204-16.

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Hutson SP, Han PK, Hamilton JG, Rife SC, Al-Rahawan MM, Moser RP, Duty SP, Anand S, Alter BP. The use of haematopoietic stem cell transplantation in Fanconi anaemia patients: a survey of decision making among families in the US and Canada. Health Expect. 2015 Oct; 18(5):929-41.

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Adair JE, Zhao X, Chien S, Fang M, Wohlfahrt ME, Trobridge GD, Taylor JA, Beard BC, Kiem HP, Becker PS. Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities. J Mol Med (Berl). 2012 Nov; 90(11):1283-94.

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Tolar J, Adair JE, Antoniou M, Bartholomae CC, Becker PS, Blazar BR, Bueren J, Carroll T, Cavazzana-Calvo M, Clapp DW, Dalgleish R, Galy A, Gaspar HB, Hanenberg H, Von Kalle C, Kiem HP, Lindeman D, Naldini L, Navarro S, Renella R, Rio P, Sevilla J, Schmidt M, Verhoeyen E, Wagner JE, Williams DA, Thrasher AJ. Stem cell gene therapy for fanconi anemia: report from the 1st international Fanconi anemia gene therapy working group meeting. Mol Ther. 2011 Jul; 19(7):1193-8.

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Cantor SB, Guillemette S. Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1. Future Oncol. 2011 Feb; 7(2):253-61.

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Suhasini AN, Rawtani NA, Wu Y, Sommers JA, Sharma S, Mosedale G, North PS, Cantor SB, Hickson ID, Brosh RM. Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome. EMBO J. 2011 Feb 16; 30(4):692-705.

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