"Guanidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
| Descriptor ID |
D019791
|
| MeSH Number(s) |
D02.078.370.472
|
| Concept/Terms |
Guanidine Hydrochloride- Guanidine Hydrochloride
- Hydrochloride, Guanidine
- Guanidinium Chloride
- Chloride, Guanidinium
- Guanidium Chloride
- Chloride, Guanidium
- Guanidine Monohydrochloride
- Monohydrochloride, Guanidine
|
Below are MeSH descriptors whose meaning is more general than "Guanidine".
Below are MeSH descriptors whose meaning is more specific than "Guanidine".
This graph shows the total number of publications written about "Guanidine" by people in this website by year, and whether "Guanidine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2011 | 1 | 1 | 2 |
| 2015 | 1 | 1 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Guanidine" by people in Profiles.
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Goswami R, Nagaraj H, Cicek YA, Nasim N, Mirza SS, Hassan MA, Mhaske R, Saravanan DM, Noonan C, Pham E, Mager J, Rotello VM. Polymer-siRNA nanovectors for treating lung inflammation. J Control Release. 2025 Feb 10; 378:1092-1102.
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Davis HC, Posey ND, Tew GN. Protein Binding and Release by Polymeric Cell-Penetrating Peptide Mimics. Biomacromolecules. 2022 01 10; 23(1):57-66.
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Basak S, Nobrega RP, Tavella D, Deveau LM, Koga N, Tatsumi-Koga R, Baker D, Massi F, Matthews CR. Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed ?a protein. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6806-6811.
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Posey ND, Hango CR, Minter LM, Tew GN. The Role of Cargo Binding Strength in Polymer-Mediated Intracellular Protein Delivery. Bioconjug Chem. 2018 08 15; 29(8):2679-2690.
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Sarapas JM, Backlund CM, deRonde BM, Minter LM, Tew GN. ROMP- and RAFT-Based Guanidinium-Containing Polymers as Scaffolds for Protein Mimic Synthesis. Chemistry. 2017 May 17; 23(28):6858-6863.
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Caffrey LM, deRonde BM, Minter LM, Tew GN. Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization. Biomacromolecules. 2016 10 10; 17(10):3205-3212.
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deRonde BM, Posey ND, Otter R, Caffrey LM, Minter LM, Tew GN. Optimal Hydrophobicity in Ring-Opening Metathesis Polymerization-Based Protein Mimics Required for siRNA Internalization. Biomacromolecules. 2016 06 13; 17(6):1969-77.
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deRonde BM, Torres JA, Minter LM, Tew GN. Development of Guanidinium-Rich Protein Mimics for Efficient siRNA Delivery into Human T Cells. Biomacromolecules. 2015 Oct 12; 16(10):3172-9.
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Lein M, deRonde BM, Sgolastra F, Tew GN, Holden MA. Protein transport across membranes: Comparison between lysine and guanidinium-rich carriers. Biochim Biophys Acta. 2015 Nov; 1848(11 Pt A):2980-4.
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Som A, Tezgel AO, Gabriel GJ, Tew GN. Self-activation in de novo designed mimics of cell-penetrating peptides. Angew Chem Int Ed Engl. 2011 Jun 27; 50(27):6147-50.