"Dizocilpine Maleate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.
| Descriptor ID |
D016291
|
| MeSH Number(s) |
D02.455.426.559.847.181.384.380 D04.615.181.384.380
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dizocilpine Maleate".
Below are MeSH descriptors whose meaning is more specific than "Dizocilpine Maleate".
This graph shows the total number of publications written about "Dizocilpine Maleate" by people in this website by year, and whether "Dizocilpine Maleate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
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Below are the most recent publications written about "Dizocilpine Maleate" by people in Profiles.
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Mitchell AC, Javidfar B, Bicks LK, Neve R, Garbett K, Lander SS, Mirnics K, Morishita H, Wood MA, Jiang Y, Gaisler-Salomon I, Akbarian S. Longitudinal assessment of neuronal 3D genomes in mouse prefrontal cortex. Nat Commun. 2016 09 06; 7:12743.
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Domingues A, Almeida S, da Cruz e Silva EF, Oliveira CR, Rego AC. Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits. Neurochem Int. 2007 May; 50(6):872-80.
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Thiex R, Weis J, Krings T, Barreiro S, Yakisikli-Alemi F, Gilsbach JM, Rohde V. Addition of intravenous N-methyl-D-aspartate receptor antagonists to local fibrinolytic therapy for the optimal treatment of experimental intracerebral hemorrhages. J Neurosurg. 2007 Feb; 106(2):314-20.
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Bitran D, Solano SM. Termination of pseudopregnancy in the rat alters the response to progesterone, chlordiazepoxide, and MK-801 in the elevated plus-maze. Psychopharmacology (Berl). 2005 Jul; 180(3):447-54.
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Li J, Guo Y, Schroeder FA, Youngs RM, Schmidt TW, Ferris C, Konradi C, Akbarian S. Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J Neurochem. 2004 Sep; 90(5):1117-31.
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Tjiattas L, Ortiz DO, Dhivant S, Mitton K, Rogers E, Shea TB. Folate deficiency and homocysteine induce toxicity in cultured dorsal root ganglion neurons via cytosolic calcium accumulation. Aging Cell. 2004 Apr; 3(2):71-6.
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Ottem EN, Godwin JG, Petersen SL. Glutamatergic signaling through the N-methyl-D-aspartate receptor directly activates medial subpopulations of luteinizing hormone-releasing hormone (LHRH) neurons, but does not appear to mediate the effects of estradiol on LHRH gene expression. Endocrinology. 2002 Dec; 143(12):4837-45.
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Shearman LP, Weaver DR. Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleus. J Biol Rhythms. 2001 Dec; 16(6):531-40.
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Leski ML, Valentine SL, Coyle JT. L-type voltage-gated calcium channels modulate kainic acid neurotoxicity in cerebellar granule cells. Brain Res. 1999 May 15; 828(1-2):27-40.
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Dunbar SA, Pulai IJ. Repetitive opioid abstinence causes progressive hyperalgesia sensitive to N-methyl-D-aspartate receptor blockade in the rat. J Pharmacol Exp Ther. 1998 Feb; 284(2):678-86.