Dipeptidyl Peptidase 4

"Dipeptidyl Peptidase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine protease that catalyses the release of an N-terminal dipeptide. Several biologically-active peptides have been identified as dipeptidyl peptidase 4 substrates including INCRETINS; NEUROPEPTIDES; and CHEMOKINES. The protein is also found bound to ADENOSINE DEAMINASE on the T-CELL surface and is believed to play a role in T-cell activation.

Descriptor ID	D018819
MeSH Number(s)	D08.811.277.656.350.350.126 D08.811.277.656.959.250 D23.050.301.264.894.160 D23.101.100.894.160
Concept/Terms	Dipeptidyl Peptidase 4 Dipeptidyl Peptidase 4 CD26 Antigen Antigen, CD26 Antigens, CD26 Adenosine Deaminase Complexing Protein 2 Dipeptidyl-Peptidase IV Dipeptidyl Peptidase IV CD26 Antigens

Below are MeSH descriptors whose meaning is more general than "Dipeptidyl Peptidase 4".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Exopeptidases [D08.811.277.656.350]
Dipeptidyl-Peptidases and Tripeptidyl-Peptidases [D08.811.277.656.350.350]
Dipeptidyl Peptidase 4 [D08.811.277.656.350.350.126]
Serine Proteases [D08.811.277.656.959]
Dipeptidyl Peptidase 4 [D08.811.277.656.959.250]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Antigens, Differentiation [D23.050.301.264]
Antigens, Differentiation, T-Lymphocyte [D23.050.301.264.894]
Dipeptidyl Peptidase 4 [D23.050.301.264.894.160]
Biomarkers [D23.101]
Antigens, Differentiation [D23.101.100]
Antigens, Differentiation, T-Lymphocyte [D23.101.100.894]
Dipeptidyl Peptidase 4 [D23.101.100.894.160]

Below are MeSH descriptors whose meaning is more specific than "Dipeptidyl Peptidase 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Dipeptidyl Peptidase 4" by people in this website by year, and whether "Dipeptidyl Peptidase 4" was a major or minor topic of these publications.

Bar chart showing 6 publications over 5 distinct years, with a maximum of 2 publications in 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
2010	1	0	1
2011	1	1	2
2018	1	0	1
2024	1	0	1

Below are the most recent publications written about "Dipeptidyl Peptidase 4" by people in Profiles.

Bisht P, Bhattacharya A, Pal A, Singh R, Verma SK. Design and synthesis of novel 3,7-dihydro-1H-purine-2,6-diones as DPP-4 inhibitors: An in silico, in vitro and in vivo approach. Eur J Med Chem. 2025 Feb 05; 283:117160.

View in: PubMed
Ghorpade DS, Ozcan L, Zheng Z, Nicoloro SM, Shen Y, Chen E, Bl?her M, Czech MP, Tabas I. Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance. Nature. 2018 03 29; 555(7698):673-677.

View in: PubMed
Stengel A, Goebel-Stengel M, Teuffel P, Hofmann T, Bu?e P, Kobelt P, Rose M, Klapp BF. Obese patients have higher circulating protein levels of dipeptidyl peptidase IV. Peptides. 2014 Nov; 61:75-82.

View in: PubMed
Dorrell C, Grompe MT, Pan FC, Zhong Y, Canaday PS, Shultz LD, Greiner DL, Wright CV, Streeter PR, Grompe M. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 2011 Jun 06; 339(1-2):144-50.

View in: PubMed
Shah Z, Pineda C, Kampfrath T, Maiseyeu A, Ying Z, Racoma I, Deiuliis J, Xu X, Sun Q, Moffatt-Bruce S, Villamena F, Rajagopalan S. Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways. Vascul Pharmacol. 2011 Jul-Sep; 55(1-3):2-9.

View in: PubMed
Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W. Interleukin-16 as a marker of S?zary syndrome onset and stage. J Clin Immunol. 2011 Feb; 31(1):39-50.

View in: PubMed
Lai JH, Wu W, Zhou Y, Maw HH, Liu Y, Milo LJ, Poplawski SE, Henry GD, Sudmeier JL, Sanford DG, Bachovchin WW. Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. J Med Chem. 2007 May 17; 50(10):2391-8.

View in: PubMed
Rose M, Walter OB, Fliege H, Hildebrandt M, M?nnikes H, Klapp BF. DPP IV and mental depression in Crohn's disease. Adv Exp Med Biol. 2003; 524:321-31.

View in: PubMed
Fliege H, Rose M, Klapp BF, Hildebrandt M. DPP IV, immune parameters, and psychometrical variables in patients with eating disorders. Adv Exp Med Biol. 2003; 524:313-20.

View in: PubMed
Korom S, De Meester I, Stadlbauer TH, Chandraker A, Schaub M, Sayegh MH, Belyaev A, Haemers A, Scharp? S, Kupiec-Weglinski JW. Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients. Transplantation. 1997 May 27; 63(10):1495-500.

View in: PubMed

People

Explore

Similar Concepts

Top Journals