JC Virus

"JC Virus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A species of POLYOMAVIRUS, originally isolated from the brain of a patient with progressive multifocal leukoencephalopathy. The patient's initials J.C. gave the virus its name. Infection is not accompanied by any apparent illness but serious demyelinating disease can appear later, probably following reactivation of latent virus.

Descriptor ID	D007577
MeSH Number(s)	B04.280.210.620.615.400 B04.613.204.670.615.400
Concept/Terms	JC Virus JC Virus Polyomavirus, JC JC polyomavirus Polyomavirus hominis 2 John Cunningham Virus Virus, John Cunningham Human Polyomavirus JC Polyomavirus JC, Human

Below are MeSH descriptors whose meaning is more general than "JC Virus".

Organisms [B]
Viruses [B04]
DNA Viruses [B04.280]
DNA Tumor Viruses [B04.280.210]
Polyomaviridae [B04.280.210.620]
Polyomavirus [B04.280.210.620.615]
JC Virus [B04.280.210.620.615.400]
Oncogenic Viruses [B04.613]
DNA Tumor Viruses [B04.613.204]
Polyomaviridae [B04.613.204.670]
Polyomavirus [B04.613.204.670.615]
JC Virus [B04.613.204.670.615.400]

Below are MeSH descriptors whose meaning is related to "JC Virus".

Below are MeSH descriptors whose meaning is more specific than "JC Virus".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "JC Virus" by people in this website by year, and whether "JC Virus" was a major or minor topic of these publications.

Bar chart showing 22 publications over 13 distinct years, with a maximum of 4 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	2	0	2
2004	1	0	1
2005	0	1	1
2006	2	0	2
2007	2	0	2
2010	1	0	1
2013	4	0	4
2014	0	1	1
2015	2	0	2
2018	1	0	1
2019	2	0	2
2020	2	0	2
2021	0	1	1

Below are the most recent publications written about "JC Virus" by people in Profiles.

O'Hara BA, Gee GV, Haley SA, Morris-Love J, Nyblade C, Nieves C, Hanson BA, Dang X, Turner TJ, Chavin JM, Lublin A, Koralnik IJ, Atwood WJ. Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells. Int J Mol Sci. 2021 Sep 10; 22(18).

View in: PubMed
Clark P, Gee GV, Albright BS, Assetta B, Han Y, Atwood WJ, DiMaio D. Phosphoinositide 3'-Kinase ? Facilitates Polyomavirus Infection. Viruses. 2020 10 20; 12(10).

View in: PubMed
O'Hara BA, Morris-Love J, Gee GV, Haley SA, Atwood WJ. JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor. PLoS Pathog. 2020 03; 16(3):e1008371.

View in: PubMed
Assetta B, Morris-Love J, Gee GV, Atkinson AL, O'Hara BA, Maginnis MS, Haley SA, Atwood WJ. Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus. Cell Rep. 2019 05 14; 27(7):1960-1966.e6.

View in: PubMed
Morris-Love J, Gee GV, O'Hara BA, Assetta B, Atkinson AL, Dugan AS, Haley SA, Atwood WJ. JC Polyomavirus Uses Extracellular Vesicles To Infect Target Cells. mBio. 2019 04 09; 10(2).

View in: PubMed
O'Hara BA, Gee GV, Atwood WJ, Haley SA. Susceptibility of Primary Human Choroid Plexus Epithelial Cells and Meningeal Cells to Infection by JC Virus. J Virol. 2018 04 15; 92(8).

View in: PubMed
Str?h LJ, Maginnis MS, Blaum BS, Nelson CD, Neu U, Gee GV, O'Hara BA, Motamedi N, DiMaio D, Atwood WJ, Stehle T. The Greater Affinity of JC Polyomavirus Capsid for a2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity. J Virol. 2015 Jun; 89(12):6364-75.

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Nelson CD, Str?h LJ, Gee GV, O'Hara BA, Stehle T, Atwood WJ. Modulation of a pore in the capsid of JC polyomavirus reduces infectivity and prevents exposure of the minor capsid proteins. J Virol. 2015 Apr; 89(7):3910-21.

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Chalkias S, Dang X, Bord E, Stein MC, Kinkel RP, Sloane JA, Donnelly M, Ionete C, Houtchens MK, Buckle GJ, Batson S, Koralnik IJ. JC virus reactivation during prolonged natalizumab monotherapy for multiple sclerosis. Ann Neurol. 2014 Jun; 75(6):925-34.

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Nelson CD, Carney DW, Derdowski A, Lipovsky A, Gee GV, O'Hara B, Williard P, DiMaio D, Sello JK, Atwood WJ. A retrograde trafficking inhibitor of ricin and Shiga-like toxins inhibits infection of cells by human and monkey polyomaviruses. mBio. 2013 Nov 12; 4(6):e00729-13.

View in: PubMed

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