Transcription Initiation Site

"Transcription Initiation Site" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.

Descriptor ID	D024363
MeSH Number(s)	G05.360.340.024.340.137.750.840
Concept/Terms	Transcription Initiation Site Transcription Initiation Site Initiation Site, Transcription Initiation Sites, Transcription Site, Transcription Initiation Sites, Transcription Initiation Transcription Initiation Sites Transcription Start Site Site, Transcription Start Sites, Transcription Start Start Site, Transcription Start Sites, Transcription Transcription Start Sites

Below are MeSH descriptors whose meaning is more general than "Transcription Initiation Site".

Biological Sciences [G]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genes [G05.360.340.024.340]
Gene Components [G05.360.340.024.340.137]
Regulatory Elements, Transcriptional [G05.360.340.024.340.137.750]
Transcription Initiation Site [G05.360.340.024.340.137.750.840]

Below are MeSH descriptors whose meaning is related to "Transcription Initiation Site".

Below are MeSH descriptors whose meaning is more specific than "Transcription Initiation Site".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Transcription Initiation Site" by people in this website by year, and whether "Transcription Initiation Site" was a major or minor topic of these publications.

Bar chart showing 35 publications over 18 distinct years, with a maximum of 4 publications in 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	0	1	1
2005	0	3	3
2006	0	1	1
2007	0	3	3
2008	0	1	1
2009	0	2	2
2010	0	1	1
2011	0	2	2
2012	2	2	4
2013	2	1	3
2014	0	1	1
2016	1	2	3
2017	0	1	1
2018	0	2	2
2019	0	3	3
2021	0	2	2
2024	0	1	1
2025	1	0	1

Below are the most recent publications written about "Transcription Initiation Site" by people in Profiles.

Calvo-Roitberg E, Carroll CL, Kim G, Sanabria V, Venev SV, Mick ST, Paquette JD, Uriostegui-Arcos M, Dekker J, Fiszbein A, Pai AA. mRNA initiation and termination are spatially coordinated. Science. 2025 Oct 09; 390(6769):eado8279.

View in: PubMed
Calvo-Roitberg E, Daniels RF, Pai AA. Challenges in identifying mRNA transcript starts and ends from long-read sequencing data. Genome Res. 2024 Nov 20; 34(11):1719-1734.

View in: PubMed
Moore JE, Zhang XO, Elhajjajy SI, Fan K, Pratt HE, Reese F, Mortazavi A, Weng Z. Integration of high-resolution promoter profiling assays reveals novel, cell type-specific transcription start sites across 115 human cell and tissue types. Genome Res. 2022 02; 32(2):389-402.

View in: PubMed
Wang W, Klein KN, Proesmans K, Yang H, Marchal C, Zhu X, Borrman T, Hastie A, Weng Z, Bechhoefer J, Chen CL, Gilbert DM, Rhind N. Genome-wide mapping of human DNA replication by optical replication mapping supports a stochastic model of eukaryotic replication. Mol Cell. 2021 07 15; 81(14):2975-2988.e6.

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Gusev FE, Reshetov DA, Mitchell AC, Andreeva TV, Dincer A, Grigorenko AP, Fedonin G, Halene T, Aliseychik M, Filippova E, Weng Z, Akbarian S, Rogaev EI. Chromatin profiling of cortical neurons identifies individual epigenetic signatures in schizophrenia. Transl Psychiatry. 2019 10 17; 9(1):256.

View in: PubMed
Zhang XO, Gingeras TR, Weng Z. Genome-wide analysis of polymerase III-transcribed Alu elements suggests cell-type-specific enhancer function. Genome Res. 2019 09; 29(9):1402-1414.

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Oomen ME, Hansen AS, Liu Y, Darzacq X, Dekker J. CTCF sites display cell cycle-dependent dynamics in factor binding and nucleosome positioning. Genome Res. 2019 02; 29(2):236-249.

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Chen W, Moore J, Ozadam H, Shulha HP, Rhind N, Weng Z, Moore MJ. Transcriptome-wide Interrogation of the Functional Intronome by Spliceosome Profiling. Cell. 2018 05 03; 173(4):1031-1044.e13.

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Ou J, Liu H, Yu J, Kelliher MA, Castilla LH, Lawson ND, Zhu LJ. ATACseqQC: a Bioconductor package for post-alignment quality assessment of ATAC-seq data. BMC Genomics. 2018 03 01; 19(1):169.

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Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol. 2017 Feb 06; 2:16274.

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