Multiple Organ Failure

"Multiple Organ Failure" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Descriptor ID	D009102
MeSH Number(s)	C23.550.835.525
Concept/Terms	Multiple Organ Failure Multiple Organ Failure Multiple Organ Dysfunction Syndrome Organ Failure, Multiple Failure, Multiple Organ Multiple Organ Failures MODS Organ Dysfunction Syndrome, Multiple

Below are MeSH descriptors whose meaning is more general than "Multiple Organ Failure".

Diseases [C]
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Shock [C23.550.835]
Multiple Organ Failure [C23.550.835.525]

Below are MeSH descriptors whose meaning is related to "Multiple Organ Failure".

Below are MeSH descriptors whose meaning is more specific than "Multiple Organ Failure".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Multiple Organ Failure" by people in this website by year, and whether "Multiple Organ Failure" was a major or minor topic of these publications.

Bar chart showing 33 publications over 21 distinct years, with a maximum of 3 publications in 2018 and 2020 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2002	0	1	1
2004	0	1	1
2005	1	1	2
2006	0	1	1
2007	0	1	1
2008	0	1	1
2010	0	1	1
2011	1	1	2
2012	1	0	1
2013	1	0	1
2014	2	0	2
2015	1	0	1
2017	1	1	2
2018	1	2	3
2020	2	1	3
2021	2	0	2
2022	0	3	3
2023	0	1	1
2025	1	0	1
2026	1	1	2

Below are the most recent publications written about "Multiple Organ Failure" by people in Profiles.

Phu K, Li C, Pauplis C, Moaddab M. Antimicrobial toxic epidermal necrolysis in an ICU patient with multisystem organ failure and sepsis. BMJ Case Rep. 2026 Apr 20; 19(4).

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Neyra JA, Legrand M, Tidswell MA, Al-Khafaji A, Galphin C, Rains R, Davison D, Tolwani A, Chen JT, Bender WS, Busse LW, Meena NK, DellaVolpe J, Williams GW, Kashani KB, Gunnerson KJ, McMahon BA, Eaton J, Khan S, Kohli-Seth R, Jagpal S, Klein D, Kamaluddin E, Foster DM, Walker PM, Tomlinson G, Kellum JA. Polymyxin B haemoadsorption in endotoxic septic shock (Tigris): a multicentre, open-label, Bayesian, randomised, controlled, phase 3 trial. Lancet Respir Med. 2026 May; 14(5):443-452.

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Molinari L, Tidswell MA, Al-Khafaji A, Davison D, Galphin C, Kamaluddin E, Foster DM, Kellum JA. Organ Failure, Endotoxin Activity, and Mortality in Septic Shock. Crit Care Explor. 2025 Sep 01; 7(9):e1308.

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Johnson AK, McCurdy VJ, Gray-Edwards HL, Maguire AS, Cochran JN, Gross AL, Skinner HE, Randle AN, Shirley JL, Brunson BL, Bradbury AM, Leroy SG, Hwang M, Rockwell HE, Cox NR, Baker HJ, Seyfried TN, Sena-Esteves M, Martin DR. Life-Limiting Peripheral Organ Dysfunction in Feline Sandhoff Disease Emerges after Effective CNS Gene Therapy. Ann Neurol. 2023 11; 94(5):969-986.

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Carter BL, Underwood J. Sepsis and the brain: a review for acute and general physicians. Clin Med (Lond). 2022 09; 22(5):392-395.

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Bosch NA, Law AC, Bor J, Myers LC, Roubinian NH, Liu VX, Walkey AJ. Red Blood Cell Transfusion at a Hemoglobin Threshold of 7 g/dl in Critically Ill Patients: A Regression Discontinuity Study. Ann Am Thorac Soc. 2022 07; 19(7):1177-1184.

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Bosch NA, Law AC, Rucci JM, Peterson D, Walkey AJ. Predictive Validity of the Sequential Organ Failure Assessment Score versus Claims-based Scores among Critically Ill Patients. Ann Am Thorac Soc. 2022 06; 19(6):1072-1076.

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Su C, Xu Z, Hoffman K, Goyal P, Safford MM, Lee J, Alvarez-Mulett S, Gomez-Escobar L, Price DR, Harrington JS, Torres LK, Martinez FJ, Campion TR, Wang F, Schenck EJ. Identifying organ dysfunction trajectory-based subphenotypes in critically ill patients with COVID-19. Sci Rep. 2021 08 05; 11(1):15872.

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Belok SH, Bosch NA, Klings ES, Walkey AJ. Evaluation of leukopenia during sepsis as a marker of sepsis-defining organ dysfunction. PLoS One. 2021; 16(6):e0252206.

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Allgaier J, Emmich M, Rastegar V, Stefan MS, Lagu T. Hypertensive urgency or emergency? The use of intravenous medications in hospitalized hypertensive patients without organ dysfunction. Heart Lung. 2020 Nov - Dec; 49(6):824-828.

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