"Uracil-DNA Glycosidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the HYDROLYSIS of the N-glycosidic bond between sugar phosphate backbone and URACIL residue during DNA synthesis.
| Descriptor ID |
D051981
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| MeSH Number(s) |
D08.811.074.249.875
|
| Concept/Terms |
Uracil-DNA Glycosidase- Uracil-DNA Glycosidase
- Glycosidase, Uracil-DNA
- Uracil DNA Glycosidase
- Ura-DNA Glycosidase
- Glycosidase, Ura-DNA
- Ura DNA Glycosidase
- Uracil-DNA Glycosylase
- Glycosylase, Uracil-DNA
- Uracil DNA Glycosylase
- DNA Glycosylase, Uracil
- Glycosylase, Uracil DNA
- Uracil N-Glycosidase
- N-Glycosidase, Uracil
- Uracil N Glycosidase
- Uracil N-Glycosylase
- N-Glycosylase, Uracil
- Uracil N Glycosylase
- Ung DNA Glycosylase
- DNA Glycosylase, Ung
- Glycosylase, Ung DNA
- Ura-DNA Glycosylase
- Glycosylase, Ura-DNA
- Ura DNA Glycosylase
|
Below are MeSH descriptors whose meaning is more general than "Uracil-DNA Glycosidase".
Below are MeSH descriptors whose meaning is more specific than "Uracil-DNA Glycosidase".
This graph shows the total number of publications written about "Uracil-DNA Glycosidase" by people in this website by year, and whether "Uracil-DNA Glycosidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Uracil-DNA Glycosidase" by people in Profiles.
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Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD. SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress. Mutat Res. 2013 Mar-Apr; 743-744:26-32.
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Svilar D, Dyavaiah M, Brown AR, Tang JB, Li J, McDonald PR, Shun TY, Braganza A, Wang XH, Maniar S, St Croix CM, Lazo JS, Pollack IF, Begley TJ, Sobol RW. Alkylation sensitivity screens reveal a conserved cross-species functionome. Mol Cancer Res. 2012 Dec; 10(12):1580-96.
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Ranjit S, Khair L, Linehan EK, Ucher AJ, Chakrabarti M, Schrader CE, Stavnezer J. AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol. 2011 Sep 01; 187(5):2464-75.
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Kothandapani A, Dangeti VS, Brown AR, Banze LA, Wang XH, Sobol RW, Patrick SM. Novel role of base excision repair in mediating cisplatin cytotoxicity. J Biol Chem. 2011 Apr 22; 286(16):14564-74.
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Schrader CE, Guikema JE, Linehan EK, Selsing E, Stavnezer J. Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. J Immunol. 2007 Nov 01; 179(9):6064-71.
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Wu X, Stavnezer J. DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination. J Exp Med. 2007 Jul 09; 204(7):1677-89.
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Schrader CE, Linehan EK, Mochegova SN, Woodland RT, Stavnezer J. Inducible DNA breaks in Ig S regions are dependent on AID and UNG. J Exp Med. 2005 Aug 15; 202(4):561-8.
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Storb U, Stavnezer J. Immunoglobulin genes: generating diversity with AID and UNG. Curr Biol. 2002 Oct 29; 12(21):R725-7.
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Sun H, Zhi C, Wright GE, Ubiali D, Pregnolato M, Verri A, Focher F, Spadari S. Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase. J Med Chem. 1999 Jul 01; 42(13):2344-50.
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Beck WR, Wright GE, Nusbaum NJ, Chang JD, Isselbacher EM. Enhancement of methotrexate cytotoxicity by uracil analogues that inhibit deoxyuridine triphosphate nucleotidohydrolase (dUTPase) activity. Adv Exp Med Biol. 1986; 195 Pt B:97-104.