Multiple System Atrophy

"Multiple System Atrophy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)

Descriptor ID	D019578
MeSH Number(s)	C10.177.575.550 C10.228.140.079.612 C10.228.662.550 C10.574.625
Concept/Terms	Multiple System Atrophy Multiple System Atrophy Atrophy, Multiple System Multiple System Atrophies Multisystem Atrophy Atrophies, Multisystem Atrophy, Multisystem Multisystem Atrophies Multisystemic Atrophy Atrophies, Multisystemic Atrophy, Multisystemic Multisystemic Atrophies Multiple System Atrophy Syndrome

Below are MeSH descriptors whose meaning is more general than "Multiple System Atrophy".

Diseases [C]
Nervous System Diseases [C10]
Autonomic Nervous System Diseases [C10.177]
Primary Dysautonomias [C10.177.575]
Multiple System Atrophy [C10.177.575.550]
Central Nervous System Diseases [C10.228]
Brain Diseases [C10.228.140]
Basal Ganglia Diseases [C10.228.140.079]
Multiple System Atrophy [C10.228.140.079.612]
Movement Disorders [C10.228.662]
Multiple System Atrophy [C10.228.662.550]
Neurodegenerative Diseases [C10.574]
Multiple System Atrophy [C10.574.625]

Below are MeSH descriptors whose meaning is related to "Multiple System Atrophy".

Below are MeSH descriptors whose meaning is more specific than "Multiple System Atrophy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Multiple System Atrophy" by people in this website by year, and whether "Multiple System Atrophy" was a major or minor topic of these publications.

Bar chart showing 11 publications over 8 distinct years, with a maximum of 3 publications in 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	0	1
2003	2	0	2
2008	1	0	1
2013	1	0	1
2014	1	0	1
2015	1	0	1
2017	3	0	3
2024	0	1	1

Below are the most recent publications written about "Multiple System Atrophy" by people in Profiles.

Gibbons CH, Levine T, Adler C, Bellaire B, Wang N, Stohl J, Agarwal P, Aldridge GM, Barboi A, Evidente VGH, Galasko D, Geschwind MD, Gonzalez-Duarte A, Gil R, Gudesblatt M, Isaacson SH, Kaufmann H, Khemani P, Kumar R, Lamotte G, Liu AJ, McFarland NR, Miglis M, Reynolds A, Sahagian GA, Saint-Hillaire MH, Schwartzbard JB, Singer W, Soileau MJ, Vernino S, Yerstein O, Freeman R. Skin Biopsy Detection of Phosphorylated a-Synuclein in Patients With Synucleinopathies. JAMA. 2024 04 16; 331(15):1298-1306.

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Novak P, Pimentel Maldonado DA, Novak V. Safety and preliminary efficacy of intranasal insulin for cognitive impairment in Parkinson disease and multiple system atrophy: A double-blinded placebo-controlled pilot study. PLoS One. 2019; 14(4):e0214364.

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Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, H?glinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J. Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting. Neurology. 2018 01 09; 90(2):74-82.

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Wang N, Edmiston EK, Luo X, Yang H, Chang M, Wang F, Fan G. Comparing abnormalities of amplitude of low-frequency fluctuations in multiple system atrophy and idiopathic Parkinson's disease measured with resting-state fMRI. Psychiatry Res Neuroimaging. 2017 Nov 30; 269:73-81.

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Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D. Natural history of pure autonomic failure: A United States prospective cohort. Ann Neurol. 2017 Feb; 81(2):287-297.

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Celedonio JE, Arnold AC, Dupont WD, Ramirez CE, Diedrich A, Okamoto LE, Raj SR, Robertson D, Peltier AC, Biaggioni I, Shibao CA. Residual sympathetic tone is associated with reduced insulin sensitivity in patients with autonomic failure. Clin Auton Res. 2015 Oct; 25(5):309-15.

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Low PA, Reich SG, Jankovic J, Shults CW, Stern MB, Novak P, Tanner CM, Gilman S, Marshall FJ, Wooten F, Racette B, Chelimsky T, Singer W, Sletten DM, Sandroni P, Mandrekar J. Natural history of multiple system atrophy in the USA: a prospective cohort study. Lancet Neurol. 2015 Jul; 14(7):710-9.

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Low PA, Robertson D, Gilman S, Kaufmann H, Singer W, Biaggioni I, Freeman R, Perlman S, Hauser RA, Cheshire W, Lessig S, Vernino S, Mandrekar J, Dupont WD, Chelimsky T, Galpern WR. Efficacy and safety of rifampicin for multiple system atrophy: a randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2014 Mar; 13(3):268-75.

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Ferguson MC, Garland EM, Hedges L, Womack-Nunley B, Hamid R, Phillips JA, Shibao CA, Raj SR, Biaggioni I, Robertson D. SHC2 gene copy number in multiple system atrophy (MSA). Clin Auton Res. 2014 Feb; 24(1):25-30.

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Novak P, Williams A, Ravin P, Zurkiya O, Abduljalil A, Novak V. Treatment of multiple system atrophy using intravenous immunoglobulin. BMC Neurol. 2012 Nov 01; 12:131.

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