"HIV Integrase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is a DNA nucleotidyltransferase encoded by the pol gene.
| Descriptor ID |
D019427
|
| MeSH Number(s) |
D08.811.739.500.667.500 D08.811.913.696.445.825.500 D12.776.964.775.375.545.500 D12.776.964.775.562.764.500 D12.776.964.970.600.850.375.545.500
|
| Concept/Terms |
HIV Integrase- HIV Integrase
- Integrase, HIV
- p31 pol Gene Product, Human Immunodeficiency Virus
- p31 Integrase Protein, Human Immunodeficiency Virus
- p31 pol Gene Product, HIV
- HIV Integration Protein
- Integration Protein, HIV
- p31 Integrase Protein, HIV
|
Below are MeSH descriptors whose meaning is more general than "HIV Integrase".
Below are MeSH descriptors whose meaning is more specific than "HIV Integrase".
This graph shows the total number of publications written about "HIV Integrase" by people in this website by year, and whether "HIV Integrase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2008 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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click here.
Below are the most recent publications written about "HIV Integrase" by people in Profiles.
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Engelman KD, Engelman AN. Long-Acting Cabotegravir for HIV/AIDS Prophylaxis. Biochemistry. 2021 06 08; 60(22):1731-1740.
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Xia J, Flynn W, Gallicchio E, Uplinger K, Armstrong JD, Forli S, Olson AJ, Levy RM. Massive-Scale Binding Free Energy Simulations of HIV Integrase Complexes Using Asynchronous Replica Exchange Framework Implemented on the IBM WCG Distributed Network. J Chem Inf Model. 2019 04 22; 59(4):1382-1397.
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Xia J, Flynn W, Levy RM. Improving Prediction Accuracy of Binding Free Energies and Poses of HIV Integrase Complexes Using the Binding Energy Distribution Analysis Method with Flattening Potentials. J Chem Inf Model. 2018 07 23; 58(7):1356-1371.
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Li M, Shandilya SM, Carpenter MA, Rathore A, Brown WL, Perkins AL, Harki DA, Solberg J, Hook DJ, Pandey KK, Parniak MA, Johnson JR, Krogan NJ, Somasundaran M, Ali A, Schiffer CA, Harris RS. First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G. ACS Chem Biol. 2012 Mar 16; 7(3):506-17.
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De Iaco A, Luban J. Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus. Retrovirology. 2011 Dec 06; 8:98.
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Luban J. HIV-1 infection: going nuclear with TNPO3/Transportin-SR2 and integrase. Curr Biol. 2008 Aug 26; 18(16):R710-3.
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Berthoux L, Sebastian S, Muesing MA, Luban J. The role of lysine 186 in HIV-1 integrase multimerization. Virology. 2007 Jul 20; 364(1):227-36.