Glucose Transporter Type 4

"Glucose Transporter Type 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glucose transport protein found in mature MUSCLE CELLS and ADIPOCYTES. It promotes transport of glucose from the BLOOD into target TISSUES. The inactive form of the protein is localized in CYTOPLASMIC VESICLES. In response to INSULIN, it is translocated to the PLASMA MEMBRANE where it facilitates glucose uptake.

Descriptor ID	D051275
MeSH Number(s)	D12.776.157.530.500.500.937 D12.776.157.530.937.563.937 D12.776.543.585.500.500.937 D12.776.543.585.937.625.937
Concept/Terms	Glucose Transporter Type 4 Glucose Transporter Type 4 Insulin-Responsive Glucose Transporter Glucose Transporter, Insulin-Responsive Insulin Responsive Glucose Transporter SLC2A4 Protein Solute Carrier Family 2, Facilitated Glucose Transporter, Member 4 Protein GLUT4 Protein GLUT-4 Protein GLUT 4 Protein

Below are MeSH descriptors whose meaning is more general than "Glucose Transporter Type 4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Monosaccharide Transport Proteins [D12.776.157.530.500]
Glucose Transport Proteins, Facilitative [D12.776.157.530.500.500]
Glucose Transporter Type 4 [D12.776.157.530.500.500.937]
Solute Carrier Proteins [D12.776.157.530.937]
Glucose Transport Proteins, Facilitative [D12.776.157.530.937.563]
Glucose Transporter Type 4 [D12.776.157.530.937.563.937]
Membrane Proteins [D12.776.543]
Membrane Transport Proteins [D12.776.543.585]
Monosaccharide Transport Proteins [D12.776.543.585.500]
Glucose Transport Proteins, Facilitative [D12.776.543.585.500.500]
Glucose Transporter Type 4 [D12.776.543.585.500.500.937]
Solute Carrier Proteins [D12.776.543.585.937]
Glucose Transport Proteins, Facilitative [D12.776.543.585.937.625]
Glucose Transporter Type 4 [D12.776.543.585.937.625.937]

Below are MeSH descriptors whose meaning is related to "Glucose Transporter Type 4".

Below are MeSH descriptors whose meaning is more specific than "Glucose Transporter Type 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Glucose Transporter Type 4" by people in this website by year, and whether "Glucose Transporter Type 4" was a major or minor topic of these publications.

Bar chart showing 40 publications over 19 distinct years, with a maximum of 5 publications in 2004 and 2007 and 2012

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	0	2	2
2002	0	1	1
2003	0	4	4
2004	0	5	5
2005	0	3	3
2006	1	1	2
2007	3	2	5
2008	0	2	2
2009	1	0	1
2010	1	0	1
2011	1	0	1
2012	3	2	5
2016	1	1	2
2017	0	1	1
2018	1	0	1
2020	0	1	1
2021	0	1	1

Below are the most recent publications written about "Glucose Transporter Type 4" by people in Profiles.

Fujimoto BA, Young M, Nakamura N, Ha H, Carter L, Pitts MW, Torres D, Noh HL, Suk S, Kim JK, Polgar N. Disrupted glucose homeostasis and skeletal-muscle-specific glucose uptake in an exocyst knockout mouse model. J Biol Chem. 2021 Jan-Jun; 296:100482.

View in: PubMed
Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Vill?n J, Wellen KE, Guertin DA. mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis. Nat Commun. 2020 Jan 29; 11(1):575.

View in: PubMed
Pillon NJ, Frendo-Cumbo S, Jacobson MR, Liu Z, Milligan PL, Hoang Bui H, Zierath JR, Bilan PJ, Brozinick JT, Klip A. Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells. J Lipid Res. 2018 07; 59(7):1148-1163.

View in: PubMed
Massart J, Sj?gren RJO, Lundell LS, Mudry JM, Franck N, O'Gorman DJ, Egan B, Zierath JR, Krook A. Altered miR-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. Diabetes. 2017 07; 66(7):1807-1818.

View in: PubMed
Ojelabi OA, Lloyd KP, Simon AH, De Zutter JK, Carruthers A. WZB117 (2-Fluoro-6-(m-hydroxybenzoyloxy) Phenyl m-Hydroxybenzoate) Inhibits GLUT1-mediated Sugar Transport by Binding Reversibly at the Exofacial Sugar Binding Site. J Biol Chem. 2016 Dec 23; 291(52):26762-26772.

View in: PubMed
Li Z, Frey JL, Wong GW, Faugere MC, Wolfgang MJ, Kim JK, Riddle RC, Clemens TL. Glucose Transporter-4 Facilitates Insulin-Stimulated Glucose Uptake in Osteoblasts. Endocrinology. 2016 Nov; 157(11):4094-4103.

View in: PubMed
Ciccarese C, Brunelli M, Montironi R, Fiorentino M, Iacovelli R, Heng D, Tortora G, Massari F. The prospect of precision therapy for renal cell carcinoma. Cancer Treat Rev. 2016 Sep; 49:37-44.

View in: PubMed
Vollers SS, Carruthers A. Sequence determinants of GLUT1-mediated accelerated-exchange transport: analysis by homology-scanning mutagenesis. J Biol Chem. 2012 Dec 14; 287(51):42533-44.

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Tan SX, Ng Y, Burchfield JG, Ramm G, Lambright DG, St?ckli J, James DE. The Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes. Mol Cell Biol. 2012 Dec; 32(24):4946-59.

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Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, St?ckli J. TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes. Traffic. 2012 Oct; 13(10):1429-41.

View in: PubMed

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