"DNA Topoisomerase IV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication.
| Descriptor ID |
D027101
|
| MeSH Number(s) |
D08.811.399.403.741.224 D12.776.097.256
|
| Concept/Terms |
parC Protein- parC Protein
- parC Gene Product, Topo IV
- Topoisomerase IV Subunit A
- parC Gene Product
parE Protein- parE Protein
- parE Gene Product, Topo IV
- Topoisomerase IV Subunit B
- parE Gene Product
|
Below are MeSH descriptors whose meaning is more general than "DNA Topoisomerase IV".
Below are MeSH descriptors whose meaning is more specific than "DNA Topoisomerase IV".
This graph shows the total number of publications written about "DNA Topoisomerase IV" by people in this website by year, and whether "DNA Topoisomerase IV" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Topoisomerase IV" by people in Profiles.
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Chambers LC, Jensen JS, Morgan JL, Lowens MS, Romano SS, Totten PA, Soge OO, Hughes JP, Golden MR, Manhart LE. Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis. Sex Transm Dis. 2019 12; 46(12):805-809.
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Akiyama T, Khan AA. Isolation and characterization of small qnrS1-carrying plasmids from imported seafood isolates of Salmonella enterica that are highly similar to plasmids of clinical isolates. FEMS Immunol Med Microbiol. 2012 Apr; 64(3):429-32.
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Bronstein JC, Olson SL, LeVier K, Tomilo M, Weber PC. Purification and characterization of recombinant Staphylococcus haemolyticus DNA gyrase and topoisomerase IV expressed in Escherichia coli. Antimicrob Agents Chemother. 2004 Jul; 48(7):2708-11.