Hypoxanthine Phosphoribosyltransferase
"Hypoxanthine Phosphoribosyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or MERCAPTOPURINE to the corresponding 5'-mononucleotides and pyrophosphate. The enzyme is important in purine biosynthesis as well as central nervous system functions. Complete lack of enzyme activity is associated with the LESCH-NYHAN SYNDROME, while partial deficiency results in overproduction of uric acid. EC 2.4.2.8.
| Descriptor ID |
D007041
|
| MeSH Number(s) |
D08.811.913.400.725.450
|
| Concept/Terms |
Hypoxanthine Phosphoribosyltransferase- Hypoxanthine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine
- IMP Pyrophosphorylase
- Pyrophosphorylase, IMP
- HGPRT
- HPRT
- HPRTase
- Hypoxanthine-Guanine Phosphoribosyltransferase
- Hypoxanthine Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Hypoxanthine-Guanine
- Guanine Phosphoribosyltransferase
- Phosphoribosyltransferase, Guanine
|
Below are MeSH descriptors whose meaning is more general than "Hypoxanthine Phosphoribosyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Hypoxanthine Phosphoribosyltransferase".
This graph shows the total number of publications written about "Hypoxanthine Phosphoribosyltransferase" by people in this website by year, and whether "Hypoxanthine Phosphoribosyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hypoxanthine Phosphoribosyltransferase" by people in Profiles.
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Maloney SC, Adair JE, Smerdon MJ, Reeves R. Gene-specific nucleotide excision repair is impaired in human cells expressing elevated levels of high mobility group A1 nonhistone proteins. DNA Repair (Amst). 2007 Sep 01; 6(9):1371-9.
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Qiu G, Harriman GR, Stavnezer J. Ialpha exon-replacement mice synthesize a spliced HPRT-C(alpha) transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice. Int Immunol. 1999 Jan; 11(1):37-46.
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Mansfield LS, Urban JF, Holley-Shanks RR, Murtaugh MP, Zarlenga DS, Foss D, Canals A, Gause W, Lunney JK. Construction of internal cDNA competitors for measuring IL-10 and IL-12 cytokine gene expression in swine. Vet Immunol Immunopathol. 1998 Sep 16; 65(1):63-74.
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Abelson HT, Gorka C. Absence of hypoxanthine:guanine phosphoribosyltransferase activity in murine Dunn osteosarcoma. Cancer Res. 1983 Sep; 43(9):4098-101.