Lactams

"Lactams" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams.

Descriptor ID	D007769
MeSH Number(s)	D02.065.589 D03.383.411
Concept/Terms	Lactams Lactams Lactims Lactims

Below are MeSH descriptors whose meaning is more general than "Lactams".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Amides [D02.065]
Lactams [D02.065.589]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 1-Ring [D03.383]
Lactams [D03.383.411]

Below are MeSH descriptors whose meaning is more specific than "Lactams".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Lactams" by people in this website by year, and whether "Lactams" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2009 and 2010 and 2012 and 2017 and 2022 and 2023 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	1	0	1
2010	1	0	1
2012	0	1	1
2017	1	0	1
2022	0	1	1
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "Lactams" by people in Profiles.

Flynn JM, Zvornicanin SN, Tsepal T, Shaqra AM, Kurt Yilmaz N, Jia W, Moquin S, Dovala D, Schiffer CA, Bolon DNA. Contributions of Hyperactive Mutations in Mpro from SARS-CoV-2 to Drug Resistance. ACS Infect Dis. 2024 04 12; 10(4):1174-1184.

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Flynn JM, Huang QYJ, Zvornicanin SN, Schneider-Nachum G, Shaqra AM, Yilmaz NK, Moquin SA, Dovala D, Schiffer CA, Bolon DNA. Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease. ACS Infect Dis. 2023 07 14; 9(7):1372-1386.

View in: PubMed
Singh N, Temin S, Baker S, Blanchard E, Brahmer JR, Celano P, Duma N, Ellis PM, Elkins IB, Haddad RY, Hesketh PJ, Jain D, Johnson DH, Leighl NB, Mamdani H, Masters G, Moffitt PR, Phillips T, Riely GJ, Robinson AG, Rosell R, Schiller JH, Schneider BJ, Spigel DR, Jaiyesimi IA. Therapy for Stage IV Non-Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline. J Clin Oncol. 2022 10 01; 40(28):3310-3322.

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Li CS, Sarotti AM, Huang P, Dang UT, Hurdle JG, Kondratyuk TP, Pezzuto JM, Turkson J, Cao S. NF-?B inhibitors, unique ?-pyranol-?-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462. Sci Rep. 2017 09 05; 7(1):10424.

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Romano KP, Ali A, Aydin C, Soumana D, Ozen A, Deveau LM, Silver C, Cao H, Newton A, Petropoulos CJ, Huang W, Schiffer CA. The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog. 2012; 8(7):e1002832.

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Kang BH, Siegelin MD, Plescia J, Raskett CM, Garlick DS, Dohi T, Lian JB, Stein GS, Languino LR, Altieri DC. Preclinical characterization of mitochondria-targeted small molecule hsp90 inhibitors, gamitrinibs, in advanced prostate cancer. Clin Cancer Res. 2010 Oct 01; 16(19):4779-88.

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Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009 Apr; 5(4):258-65.

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Lai JH, Wu W, Zhou Y, Maw HH, Liu Y, Milo LJ, Poplawski SE, Henry GD, Sudmeier JL, Sanford DG, Bachovchin WW. Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines. J Med Chem. 2007 May 17; 50(10):2391-8.

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Griffiths JK, Daly JS, Dodge RA. Two cases of endocarditis due to Lactobacillus species: antimicrobial susceptibility, review, and discussion of therapy. Clin Infect Dis. 1992 Aug; 15(2):250-5.

View in: PubMed

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