Receptors, GABA-A

"Receptors, GABA-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.

Descriptor ID	D011963
MeSH Number(s)	D12.776.157.530.400.175.562 D12.776.157.530.400.400.100.100 D12.776.543.550.450.175.562 D12.776.543.550.450.500.100.100 D12.776.543.585.400.175.562 D12.776.543.585.400.500.100.100 D12.776.543.750.130.500 D12.776.543.750.720.200.300.300
Concept/Terms	Receptors, GABA-A Receptors, GABA-A Receptors, GABA A GABA-A Receptor GABA A Receptor Receptor, GABA-A GABA-A Receptors GABA A Receptors gamma-Aminobutyric Acid Subtype A Receptors gamma Aminobutyric Acid Subtype A Receptors Muscimol Receptor Receptor, Muscimol Receptors, Benzodiazepine-GABA Receptors, Benzodiazepine GABA Receptors, Muscimol Benzodiazepine-GABA Receptor Benzodiazepine GABA Receptor Receptor, Benzodiazepine-GABA GABA-Benzodiazepine Receptor GABA Benzodiazepine Receptor Receptor, GABA-Benzodiazepine GABA-Benzodiazepine Receptors GABA Benzodiazepine Receptors Benzodiazepine-Gaba Receptors Benzodiazepine Gaba Receptors Receptors, GABA-Benzodiazepine Receptors, GABA Benzodiazepine GABA(A) Receptor Muscimol Receptors GABA-A Receptor alpha Subunit GABA-A Receptor alpha Subunit GABA A Receptor alpha Subunit GABA-A Receptor rho Subunit GABA-A Receptor rho Subunit GABA A Receptor rho Subunit GABA-A Receptor delta Subunit GABA-A Receptor delta Subunit GABA A Receptor delta Subunit delta Subunit, GABA-A Receptor delta Subunit, GABA A Receptor GABA-A Receptor epsilon Subunit GABA-A Receptor epsilon Subunit GABA A Receptor epsilon Subunit epsilon Subunit, GABA-A Receptor epsilon Subunit, GABA A Receptor GABA-A Receptor gamma Subunit GABA-A Receptor gamma Subunit GABA A Receptor gamma Subunit Benzodiazepine Receptor Benzodiazepine Receptor Receptor, Benzodiazepine Receptors, Diazepam Diazepam Receptor Receptor, Diazepam Diazepam Receptors Benzodiazepine Receptors Receptors, Benzodiazepine GABA-A Receptor beta Subunit GABA-A Receptor beta Subunit GABA A Receptor beta Subunit

Below are MeSH descriptors whose meaning is more general than "Receptors, GABA-A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Chloride Channels [D12.776.157.530.400.175]
Receptors, GABA-A [D12.776.157.530.400.175.562]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
Receptors, GABA-A [D12.776.157.530.400.400.100.100]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Chloride Channels [D12.776.543.550.450.175]
Receptors, GABA-A [D12.776.543.550.450.175.562]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
Receptors, GABA-A [D12.776.543.550.450.500.100.100]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Chloride Channels [D12.776.543.585.400.175]
Receptors, GABA-A [D12.776.543.585.400.175.562]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
Receptors, GABA-A [D12.776.543.585.400.500.100.100]
Receptors, Cell Surface [D12.776.543.750]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
Receptors, GABA-A [D12.776.543.750.130.500]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Amino Acid [D12.776.543.750.720.200]
Receptors, GABA [D12.776.543.750.720.200.300]
Receptors, GABA-A [D12.776.543.750.720.200.300.300]

Below are MeSH descriptors whose meaning is related to "Receptors, GABA-A".

Below are MeSH descriptors whose meaning is more specific than "Receptors, GABA-A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, GABA-A" by people in this website by year, and whether "Receptors, GABA-A" was a major or minor topic of these publications.

Bar chart showing 19 publications over 15 distinct years, with a maximum of 2 publications in 2000 and 2002 and 2010 and 2022

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	2	0	2
2002	0	2	2
2003	1	0	1
2004	0	1	1
2005	1	0	1
2009	1	0	1
2010	1	1	2
2011	1	0	1
2012	1	0	1
2013	1	0	1
2014	1	0	1
2016	0	1	1
2018	1	0	1
2019	1	0	1
2022	1	1	2

Below are the most recent publications written about "Receptors, GABA-A" by people in Profiles.

Barnaby W, Dorman Barclay HE, Nagarkar A, Perkins M, Teicher G, Trapani JG, Downes GB. GABAA a subunit control of hyperactive behavior in developing zebrafish. Genetics. 2022 04 04; 220(4).

View in: PubMed
Chaturvedi R, Stork T, Yuan C, Freeman MR, Emery P. Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons. Curr Biol. 2022 05 09; 32(9):1895-1908.e5.

View in: PubMed
Gunduz-Bruce H, Silber C, Kaul I, Rothschild AJ, Riesenberg R, Sankoh AJ, Li H, Lasser R, Zorumski CF, Rubinow DR, Paul SM, Jonas J, Doherty JJ, Kanes SJ. Trial of SAGE-217 in Patients with Major Depressive Disorder. N Engl J Med. 2019 09 05; 381(10):903-911.

View in: PubMed
Monesson-Olson B, McClain JJ, Case AE, Dorman HE, Turkewitz DR, Steiner AB, Downes GB. Expression of the eight GABAA receptor a subunits in the developing zebrafish central nervous system. PLoS One. 2018; 13(4):e0196083.

View in: PubMed
Deligiannidis KM, Kroll-Desrosiers AR, Mo S, Nguyen HP, Svenson A, Jaitly N, Hall JE, Barton BA, Rothschild AJ, Shaffer SA. Peripartum neuroactive steroid and ?-aminobutyric acid profiles in women at-risk for postpartum depression. Psychoneuroendocrinology. 2016 08; 70:98-107.

View in: PubMed
Lin WC, Davenport CM, Mourot A, Vytla D, Smith CM, Medeiros KA, Chambers JJ, Kramer RH. Engineering a light-regulated GABAA receptor for optical control of neural inhibition. ACS Chem Biol. 2014 Jul 18; 9(7):1414-9.

View in: PubMed
Wills TA, Kash TL, Winder DG. Developmental changes in the acute ethanol sensitivity of glutamatergic and GABAergic transmission in the BNST. Alcohol. 2013 Nov; 47(7):531-7.

View in: PubMed
Smelson D, Yu L, Buyske S, Gonzalez G, Tischfield J, Deutsch CK, Ziedonis D. Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. Am J Addict. 2012 Sep-Oct; 21(5):411-5.

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Anaclet C, Zhang M, Zhao C, Buda C, Seugnet L, Lin JS. Effects of GF-015535-00, a novel a1 GABA A receptor ligand, on the sleep-wake cycle in mice, with reference to zolpidem. Sleep. 2012 Jan 01; 35(1):103-11.

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Sarkar J, Wakefield S, MacKenzie G, Moss SJ, Maguire J. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 2011 Dec 14; 31(50):18198-210.

View in: PubMed

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