Enkephalins

"Enkephalins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

One of the three major families of endogenous opioid peptides. The enkephalins are pentapeptides that are widespread in the central and peripheral nervous systems and in the adrenal medulla.

Descriptor ID	D004745
MeSH Number(s)	D12.644.400.575.281 D12.776.631.650.575.281
Concept/Terms	Enkephalins Enkephalins Enkephalin

Below are MeSH descriptors whose meaning is more general than "Enkephalins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Neuropeptides [D12.644.400]
Opioid Peptides [D12.644.400.575]
Enkephalins [D12.644.400.575.281]
Proteins [D12.776]
Nerve Tissue Proteins [D12.776.631]
Neuropeptides [D12.776.631.650]
Opioid Peptides [D12.776.631.650.575]
Enkephalins [D12.776.631.650.575.281]

Below are MeSH descriptors whose meaning is related to "Enkephalins".

Below are MeSH descriptors whose meaning is more specific than "Enkephalins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Enkephalins" by people in this website by year, and whether "Enkephalins" was a major or minor topic of these publications.

Bar chart showing 8 publications over 7 distinct years, with a maximum of 2 publications in 2016

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2007	1	0	1
2008	0	1	1
2013	0	1	1
2015	1	0	1
2016	1	1	2
2019	1	0	1
2025	1	0	1

Below are the most recent publications written about "Enkephalins" by people in Profiles.

Wenzl FA, Wang P, Arrigo M, Parenica J, Jones DJL, Bruno F, Tarnowski D, Hartmann O, Boucek L, Lang F, Obeid S, Schober A, Kraler S, Akhmedov A, Kahles F, Schober A, Ow KW, Ministrini S, Camici GG, Bergmann A, Liberale L, Jarkovsky J, Schweiger V, Sandhu JK, von Eckardstein A, Templin C, Muller O, Ondrus T, Olic JJ, Roffi M, R?ber L, Cao TH, Jungbauer CG, Ng LL, Mebazaa A, L?scher TF. Proenkephalin improves cardio-renal risk prediction in acute coronary syndromes: the KID-ACS score. Eur Heart J. 2025 Jan 03; 46(1):38-54.

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Emmens JE, Ter Maaten JM, Damman K, van Veldhuisen DJ, de Boer RA, Struck J, Bergmann A, Sama IE, Streng KW, Anker SD, Dickstein K, Lang CC, Metra M, Samani NJ, Ng LL, Voors AA. Proenkephalin, an Opioid System Surrogate, as a Novel Comprehensive Renal Marker in Heart Failure. Circ Heart Fail. 2019 05; 12(5):e005544.

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Schulz CA, Christensson A, Ericson U, Almgren P, Hindy G, Nilsson PM, Struck J, Bergmann A, Melander O, Orho-Melander M. High Level of Fasting Plasma Proenkephalin-A Predicts Deterioration of Kidney Function and Incidence of CKD. J Am Soc Nephrol. 2017 Jan; 28(1):291-303.

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Min SY, Kady J, Nam M, Rojas-Rodriguez R, Berkenwald A, Kim JH, Noh HL, Kim JK, Cooper MP, Fitzgibbons T, Brehm MA, Corvera S. Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice. Nat Med. 2016 Mar; 22(3):312-8.

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Melander O, Orho-Melander M, Manjer J, Svensson T, Almgren P, Nilsson PM, Engstr?m G, Hedblad B, Borgquist S, Hartmann O, Struck J, Bergmann A, Belting M. Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk. J Clin Oncol. 2015 Aug 20; 33(24):2632-8.

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Romero-Pic? A, V?zquez MJ, Gonz?lez-Touceda D, Folgueira C, Skibicka KP, Alvarez-Crespo M, Van Gestel MA, Vel?squez DA, Schwarzer C, Herzog H, L?pez M, Adan RA, Dickson SL, Di?guez C, Nogueiras R. Hypothalamic ?-opioid receptor modulates the orexigenic effect of ghrelin. Neuropsychopharmacology. 2013 Jun; 38(7):1296-307.

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Vinuela A, Hallett PJ, Reske-Nielsen C, Patterson M, Sotnikova TD, Caron MG, Gainetdinov RR, Isacson O. Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. Brain. 2008 Dec; 131(Pt 12):3361-79.

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Denning GM, Ackermann LW, Barna TJ, Armstrong JG, Stoll LL, Weintraub NL, Dickson EW. Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues. Peptides. 2008 Jan; 29(1):83-92.

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Heagy W, Teng E, Lopez P, Finberg RW. Enkephalin receptors and receptor-mediated signal transduction in cultured human lymphocytes. Cell Immunol. 1999 Jan 10; 191(1):34-48.

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Heagy W, Duca K, Finberg RW. Enkephalins stimulate leukemia cell migration and surface expression of CD9. J Clin Invest. 1995 Sep; 96(3):1366-74.

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