Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo. Blood. 2007 Apr 15; 109(8):3441-50.
-
Animals
-
Antineoplastic Agents
-
Apoptosis
-
Chromosomes, Human, Pair 21
-
Chromosomes, Human, Pair 8
-
Core Binding Factor Alpha 2 Subunit
-
Cytarabine
-
Diterpenes
-
Diterpenes, Kaurane
-
Drug Screening Assays, Antitumor
-
Drug Synergism
-
Humans
-
Leukemia, Myeloid, Acute
-
Mice
-
Mice, Nude
-
Neoplasms, Experimental
-
Oncogene Proteins, Fusion
-
Plant Extracts
-
Plants, Medicinal
-
RUNX1 Translocation Partner 1 Protein
-
Translocation, Genetic
-
U937 Cells