Src Homology 2 Domain-Containing, Transforming Protein 1
"Src Homology 2 Domain-Containing, Transforming Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.
| Descriptor ID |
D000071425
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| MeSH Number(s) |
D12.644.360.024.330.500 D12.776.157.057.162.500 D12.776.476.024.424.500
|
| Concept/Terms |
Src Homology 2 Domain-Containing, Transforming Protein 1- Src Homology 2 Domain-Containing, Transforming Protein 1
- Src Homology 2 Domain Containing, Transforming Protein 1
- ShcA Protein
- SHC1 (Src Homology 2 Domain-Containing) Protein
- Src Homology 2 Domain-Containing-Transforming Protein C1
- Src Homology 2 Domain Containing Transforming Protein C1
- SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
- SHC1 Protein
- SHC-Transforming Protein 1
- SHC Transforming Protein 1
|
Below are MeSH descriptors whose meaning is more general than "Src Homology 2 Domain-Containing, Transforming Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Src Homology 2 Domain-Containing, Transforming Protein 1".
This graph shows the total number of publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in this website by year, and whether "Src Homology 2 Domain-Containing, Transforming Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
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Below are the most recent publications written about "Src Homology 2 Domain-Containing, Transforming Protein 1" by people in Profiles.
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Grossman SR, Lyle S, Resnick MB, Sabo E, Lis RT, Rosinha E, Liu Q, Hsieh CC, Bhat G, Frackelton AR, Hafer LJ. p66 Shc tumor levels show a strong prognostic correlation with disease outcome in stage IIA colon cancer. Clin Cancer Res. 2007 Oct 01; 13(19):5798-804.
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Harrington M, Pond-Tor S, Boney CM. Role of epidermal growth factor and ErbB2 receptors in 3T3-L1 adipogenesis. Obesity (Silver Spring). 2007 Mar; 15(3):563-71.
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Boney CM, Gruppuso PA, Faris RA, Frackelton AR. The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes. Mol Endocrinol. 2000 Jun; 14(6):805-13.
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Boney CM, Smith RM, Gruppuso PA. Modulation of insulin-like growth factor I mitogenic signaling in 3T3-L1 preadipocyte differentiation. Endocrinology. 1998 Apr; 139(4):1638-44.