The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, M?ller-Fielitz H, Schuster R, Zille M, M?ller K, Krohn M, K?rbelin J, Zhang L, ?zorhan ?, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, F?hnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Co?lho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, K?nig P, Busch H, Collin L, Villase?or R, J?hren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, P?schel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. 2021 11; 24(11):1522-1533.