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Erik Wang MD

TitleAssistant Professor
InstitutionUMass Chan Medical School
DepartmentEmergency Medicine at UMass Chan - Lahey
AddressLahey Hospital and Medical Center
41 Mall Road
Burlington MA 01805
Phone781-552-0993
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentEmergency Medicine at UMass Chan - Lahey


    Collapse Biography 
    Collapse education and training
    Dartmouth College, Hanover, NH, United StatesBAGenetics, Cell & Developmental
    Vanderbilt University School of Medicine, Nashville, TN, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Han J, Kanelli M, Liu Y, Daristotle JL, Pardeshi A, Forster TA, Karchin A, Folk B, Murmann L, Tostanoski LH, Carrasco SE, Alsaiari SK, Wang EY, Tran K, Zhang L, Eshaghi B, Levy L, Pyon S, Sloane C, Lin SQ, Lau A, Perkinson CF, Bawendi MG, Barouch DH, Durand F, Langer R, Jaklenec A. On-patient medical record and mRNA therapeutics using intradermal microneedles. Nat Mater. 2025 Feb 24. PMID: 39994390.
      Citations:    
    2. Wu Q, Rafatian N, Wagner KT, Blamer J, Smith J, Okhovatian S, Aggarwal P, Wang EY, Banerjee A, Zhao Y, Nash TR, Lu RXZ, Portillo-Esquivel LE, Li CY, Kuzmanov U, Mandla S, Virlee E, Landau S, Lai BF, Gramolini AO, Liu C, Fleischer S, Veres T, Vunjak-Novakovic G, Zhang B, Mossman K, Broeckel U, Radisic M. SARS-CoV-2 pathogenesis in an angiotensin II-induced heart-on-a-chip disease model and extracellular vesicle screening. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2403581121. PMID: 38968108.
      Citations:    
    3. Okhovatian S, Khosravi R, Wang EY, Zhao Y, Radisic M. Biofabrication strategies for cardiac tissue engineering. Curr Opin Biotechnol. 2024 Aug; 88:103166. PMID: 38941865.
      Citations:    
    4. Hamidzada H, Pascual-Gil S, Wu Q, Kent GM, Mass? S, Kantores C, Kuzmanov U, Gomez-Garcia MJ, Rafatian N, Gorman RA, Wauchop M, Chen W, Landau S, Subha T, Atkins MH, Zhao Y, Beroncal E, Fernandes I, Nanthakumar J, Vohra S, Wang EY, Sadikov TV, Razani B, McGaha TL, Andreazza AC, Gramolini A, Backx PH, Nanthakumar K, Laflamme MA, Keller G, Radisic M, Epelman S. Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways. Nat Cardiovasc Res. 2024 May; 3(5):567-593. PMID: 39086373.
      Citations:    
    5. Kinnear C, Said A, Meng G, Zhao Y, Wang EY, Rafatian N, Parmar N, Wei W, Billia F, Simmons CA, Radisic M, Ellis J, Mital S. Myosin inhibitor reverses hypertrophic cardiomyopathy in genotypically diverse pediatric iPSC-cardiomyocytes to mirror variant correction. Cell Rep Med. 2024 May 21; 5(5):101520. PMID: 38642550.
      Citations:    
    6. Alsaiari SK, Nadeef S, Daristotle JL, Rothwell W, Du B, Garcia J, Zhang L, Sarmadi M, Forster TA, Menon N, Lin SQ, Tostanoski LH, Hachmann N, Wang EY, Ventura JD, Barouch DH, Langer R, Jaklenec A. Zeolitic imidazolate frameworks activate endosomal Toll-like receptors and potentiate immunogenicity of SARS-CoV-2 spike protein trimer. Sci Adv. 2024 Mar 08; 10(10):eadj6380. PMID: 38446889.
      Citations:    
    7. Wu Q, Xue R, Zhao Y, Ramsay K, Wang EY, Savoji H, Veres T, Cartmell SH, Radisic M. Automated fabrication of a scalable heart-on-a-chip device by 3D printing of thermoplastic elastomer nanocomposite and hot embossing. Bioact Mater. 2024 Mar; 33:46-60. PMID: 38024233.
      Citations:    
    8. Kieda J, Shakeri A, Landau S, Wang EY, Zhao Y, Lai BF, Okhovatian S, Wang Y, Jiang R, Radisic M. Advances in cardiac tissue engineering and heart-on-a-chip. J Biomed Mater Res A. 2024 04; 112(4):492-511. PMID: 37909362.
      Citations:    
    9. Wang EY, Sarmadi M, Ying B, Jaklenec A, Langer R. Recent advances in nano- and micro-scale carrier systems for controlled delivery of vaccines. Biomaterials. 2023 12; 303:122345. PMID: 37918182.
      Citations:    
    10. Wauchop M, Rafatian N, Zhao Y, Chen W, Gagliardi M, Mass? S, Cox BJ, Lai P, Liang T, Landau S, Protze S, Gao XD, Wang EY, Tung KC, Laksman Z, Lu RXZ, Keller G, Nanthakumar K, Radisic M, Backx PH. Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation. Biomaterials. 2023 10; 301:122255. PMID: 37651922.
      Citations:    
    11. Zhao Y, Wang EY, Lai FBL, Cheung K, Radisic M. Organs-on-a-chip: a union of tissue engineering and microfabrication. Trends Biotechnol. 2023 03; 41(3):410-424. PMID: 36725464.
      Citations:    
    12. Wang EY, Zhao Y, Okhovatian S, Smith JB, Radisic M. Intersection of stem cell biology and engineering towards next generation in vitro models of human fibrosis. Front Bioeng Biotechnol. 2022; 10:1005051. PMID: 36338120.
      Citations:    
    13. Wang EY, Smith J, Radisic M. Design and Fabrication of Biological Wires for Cardiac Fibrosis Disease Modeling. Methods Mol Biol. 2022; 2485:175-190. PMID: 35618906.
      Citations:    
    14. Wang EY, Kuzmanov U, Smith JB, Dou W, Rafatian N, Lai BFL, Lu RXZ, Wu Q, Yazbeck J, Zhang XO, Sun Y, Gramolini A, Radisic M. An organ-on-a-chip model for pre-clinical drug evaluation in progressive non-genetic cardiomyopathy. J Mol Cell Cardiol. 2021 11; 160:97-110. PMID: 34216608.
      Citations:    
    15. Lai BFL, Lu RXZ, Davenport Huyer L, Kakinoki S, Yazbeck J, Wang EY, Wu Q, Zhang B, Radisic M. A well plate-based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nat Protoc. 2021 04; 16(4):2158-2189. PMID: 33790475.
      Citations:    
    16. Kuzmanov U, Wang EY, Vanderlaan R, Kim DH, Lee SH, Hadipour-Lakmehsari S, Guo H, Zhao Y, McFadden M, Sharma P, Billia F, Radisic M, Gramolini A, Emili A. Mapping signalling perturbations in myocardial fibrosis via the integrative phosphoproteomic profiling of tissue from diverse sources. Nat Biomed Eng. 2020 09; 4(9):889-900. PMID: 32661320.
      Citations:    
    17. Lai Benjamin FL, Lu Rick X, Hu Y, Davenport HL, Dou W, Wang EY, Radulovich N, Tsao MS, Sun Y, Radisic M. Recapitulating pancreatic tumor microenvironment through synergistic use of patient organoids and organ-on-a-chip vasculature. Adv Funct Mater. 2020 Nov 25; 30(48). PMID: 33692660.
      Citations:    
    18. Zhao Y, Rafatian N, Wang EY, Wu Q, Lai BFL, Lu RX, Savoji H, Radisic M. Towards chamber specific heart-on-a-chip for drug testing applications. Adv Drug Deliv Rev. 2020; 165-166:60-76. PMID: 31917972.
      Citations:    
    19. Wang EY, Rafatian N, Zhao Y, Lee A, Lai BFL, Lu RX, Jekic D, Davenport Huyer L, Knee-Walden EJ, Bhattacharya S, Backx PH, Radisic M. Biowire Model of Interstitial and Focal Cardiac Fibrosis. ACS Cent Sci. 2019 Jul 24; 5(7):1146-1158. PMID: 31403068.
      Citations:    
    20. Zhao Y, Rafatian N, Wang EY, Feric NT, Lai BFL, Knee-Walden EJ, Backx PH, Radisic M. Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform. Matrix Biol. 2020 01; 85-86:189-204. PMID: 30981898.
      Citations:    
    21. Zhao Y, Wang EY, Davenport LH, Liao Y, Yeager K, Vunjak-Novakovic G, Radisic M, Zhang B. A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires. Adv Healthc Mater. 2019 03; 8(5):e1801187. PMID: 30737909.
      Citations:    
    22. Zhao Y, Rafatian N, Feric NT, Cox BJ, Aschar-Sobbi R, Wang EY, Aggarwal P, Zhang B, Conant G, Ronaldson-Bouchard K, Pahnke A, Protze S, Lee JH, Davenport Huyer L, Jekic D, Wickeler A, Naguib HE, Keller GM, Vunjak-Novakovic G, Broeckel U, Backx PH, Radisic M. A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling. Cell. 2019 02 07; 176(4):913-927.e18. PMID: 30686581.
      Citations:    
    23. Savoji H, Mohammadi MH, Rafatian N, Toroghi MK, Wang EY, Zhao Y, Korolj A, Ahadian S, Radisic M. Cardiovascular disease models: A game changing paradigm in drug discovery and screening. Biomaterials. 2019 04; 198:3-26. PMID: 30343824.
      Citations:    
    24. Korolj A, Wang EY, Civitarese RA, Radisic M. Biophysical stimulation for in?vitro engineering of functional cardiac tissues. Clin Sci (Lond). 2017 Jul 01; 131(13):1393-1404. PMID: 28645929.
      Citations:    
    25. Conant G, Lai BFL, Lu RXZ, Korolj A, Wang EY, Radisic M. High-Content Assessment of Cardiac Function Using Heart-on-a-Chip Devices as Drug Screening Model. Stem Cell Rev Rep. 2017 Jun; 13(3):335-346. PMID: 28429185.
      Citations:    
    26. Wang EY, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum LA. p53 mediates autophagy and cell death by a mechanism contingent on Bnip3. Hypertension. 2013 Jul; 62(1):70-7. PMID: 23648705.
      Citations:    
    27. Wang EY, Biala AK, Gordon JW, Kirshenbaum LA. Autophagy in the heart: too much of a good thing? J Cardiovasc Pharmacol. 2012 Aug; 60(2):110-7. PMID: 22343372.
      Citations:    
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