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HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.
Voacanga
TMC310911, a novel human immunodeficiency virus type 1 protease inhibitor, shows in vitro an improved resistance profile and higher genetic barrier to resistance compared with current protease inhibitors.
Promise of advances in simulation methods for protein crystallography: implicit solvent models, time-averaging refinement, and quantum mechanical modeling.
Time to re-examine old definitions of nicotine dependence.
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Time to re-examine old definitions of nicotine dependence.
DiFranza JR, Riggs N, Ann Pentz M. Time to re-examine old definitions of nicotine dependence. Nicotine Tob Res. 2008 Jun; 10(6):1109-11.
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PubMed
subject areas
Adolescent
Adult
Behavior, Addictive
Diagnostic and Statistical Manual of Mental Disorders
Humans
Personal Autonomy
Personality Assessment
Research Design
Substance-Related Disorders
Tobacco Use Disorder
authors with profiles
Joseph R DiFranza MD