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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
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BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription.
Sheng Z, Ma L, Sun JE, Zhu LJ, Green MR. BCR-ABL suppresses autophagy through ATF5-mediated regulation of mTOR transcription. Blood. 2011 Sep 08; 118(10):2840-8.
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PubMed
subject areas
Activating Transcription Factors
Animals
Antineoplastic Agents
Autophagy
Benzamides
Blotting, Western
Cell Transformation, Neoplastic
Chromatin Immunoprecipitation
Fusion Proteins, bcr-abl
Gene Expression Regulation, Neoplastic
Humans
Imatinib Mesylate
Immunosuppressive Agents
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Luciferases
Mice
Phosphatidylinositol 3-Kinases
Phosphorylation
Piperazines
Promoter Regions, Genetic
Proto-Oncogene Proteins c-akt
Pyrimidines
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Sirolimus
TOR Serine-Threonine Kinases
Transcription, Genetic
authors with profiles
Lihua Zhu PhD