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    Sally C Kent PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    368 Plantation Street, AS7-2012
    Worcester MA 01605
    Phone508-856-2044
        Overview 
        Narrative

        RESEARCHINTERESTS

         

        Autoreactive T cell specificity and function inhuman Type 1 diabetes

        Autoreactive B cell specificity and function inhuman Type 1 diabetes

        Development of autoreactive T cell memory in humanType 1 diabetes

        Anergy induction in human Type 1 diabetes

        Enterovirus in human Type 1 diabetes

        Functionalsuppression of T cell activity by umbilical cord-derived mesenchymal stem cells

         

         

         

        EDUCATIONand TRAINING

         

        Ph.D.

        Loyola University of Chicago, Stritch School ofMedicine

         

        Post doctoral Fellowships

        University of Rochester School of Medicine andDentistry

        Brigham and Women’s Hospital and Harvard MedicalSchool

         

        ACADEMICAPPOINTMENTS

         

        Instructor in Neurology

        Harvard Medical School

         

        Associate Immunologist

        Brigham and Women’s Hospital

         

        Assistant Professor in Neurology

        Harvard Medical School

         

        AssistantProfessor in Medicine           

        University of Massachusetts Medical School, DiabetesCenter of Excellence

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased Frequencies of Myelin Oligodendrocyte Glycoprotein/MHC Class II-Binding CD4 Cells in Patients with Multiple Sclerosis. J Immunol. 2011 Jul 15; 187(2):1039-46.
          View in: PubMed
        2. Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem. 2010 Jan 15; 82(2):473-7.
          View in: PubMed
        3. Sharma AK, Ling Y, Greer AB, Hafler DA, Kent SC, Zhang Y, Rigby AC. Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry. J Phys Chem B. 2010 Jan 14; 114(1):585-91.
          View in: PubMed
        4. Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 1; 183(7):4432-9.
          View in: PubMed
        5. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501.
          View in: PubMed
        6. Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct; 129(1):10-8.
          View in: PubMed
        7. Hava DL, van der Wel N, Cohen N, Dascher CC, Houben D, León L, Agarwal S, Sugita M, van Zon M, Kent SC, Shams H, Peters PJ, Brenner MB. Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11281-6.
          View in: PubMed
        8. Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an islet transplant 2 years after transplantation: evidence for a nonimmunological loss. Transplantation. 2008 Jul 15; 86(1):54-62.
          View in: PubMed
        9. Waziri A, Killory B, Ogden AT, Canoll P, Anderson RC, Kent SC, Anderson DE, Bruce JN. Preferential in situ CD4+CD56+ T cell activation and expansion within human glioblastoma. J Immunol. 2008 Jun 1; 180(11):7673-80.
          View in: PubMed
        10. Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. J Immunol. 2008 Mar 1; 180(5):2876-85.
          View in: PubMed
        11. Kis J, Engelmann P, Farkas K, Richman G, Eck S, Lolley J, Jalahej H, Borowiec M, Kent SC, Treszl A, Orban T. Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus. J Leukoc Biol. 2007 Mar; 81(3):654-62.
          View in: PubMed
        12. van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB. Apolipoprotein-mediated pathways of lipid antigen presentation. Nature. 2005 Oct 6; 437(7060):906-10.
          View in: PubMed
        13. Kent SC, Chen Y, Clemmings SM, Viglietta V, Kenyon NS, Ricordi C, Hering B, Hafler DA. Loss of IL-4 secretion from human type 1a diabetic pancreatic draining lymph node NKT cells. J Immunol. 2005 Oct 1; 175(7):4458-64.
          View in: PubMed
        14. Quintana FJ, Gerber D, Kent SC, Cohen IR, Shai Y. HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation. J Clin Invest. 2005 Aug; 115(8):2149-58.
          View in: PubMed
        15. Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA. Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature. 2005 May 12; 435(7039):224-8.
          View in: PubMed
        16. Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB. Mechanism of CD1d-restricted natural killer T cell activation during microbial infection. Nat Immunol. 2003 Dec; 4(12):1230-7.
          View in: PubMed
        17. Viglietta V, Kent SC, Orban T, Hafler DA. GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest. 2002 Apr; 109(7):895-903.
          View in: PubMed
        18. Brandvold KA, Ewert DL, Kent SC, Neiman P, Ruddell A. Blocked B cell differentiation and emigration support the early growth of Myc-induced lymphomas. Oncogene. 2001 May 31; 20(25):3226-34.
          View in: PubMed
        19. Scott DW, Warner GL, Yao XR, Kent SC. Pathways and regulation of B-cell responsiveness and tolerance. Chem Immunol. 1994; 58:34-66.
          View in: PubMed
        20. Fischer G, Kent SC, Joseph L, Green DR, Scott DW. Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med. 1994 Jan 1; 179(1):221-8.
          View in: PubMed
        21. Ludlum DB, Kent S, Mehta JR. Formation of O6-ethylthioethylguanine in DNA by reaction with the sulfur mustard, chloroethyl sulfide, and its apparent lack of repair by O6-alkylguanine-DNA alkyltransferase. Carcinogenesis. 1986 Jul; 7(7):1203-6.
          View in: PubMed
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