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    Ingolf M Bach PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentProgram in Molecular Medicine
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB-513
    Worcester MA 01605
    Phone508-856-5627
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCancer Biology

      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentTranslational Science

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentProgram in Gene Function and Expression

        Overview 
        Narrative

        Academic Background

        Ingolf Bach carried out his doctoral work at the Pasteur Institute in Paris, supported by the Boehringer Ingelheim Foundation. He received his Ph.D. in 1993 from the University of Paris VII. Supported by fellowships from EMBO and HFSPO, he was a post-doctoral fellow from 1993 to 1996 and, later, an Assistant Research Biologist at the University of California, San Diego. From 1998 to 2005, he was an Assistant Professor and Heisenberg Scholar at the Center for Molecular Neurobiology at the University of Hamburg. Dr. Bach joined the Program in Gene Function and Expression at the University of Massachusetts Medical School as an Associate Professor in June of 2005.

        Neuronal Cell Fate Specification

        Photo: Ingolf Bach, Ph.D.

        A fundamental question in biology is how protein complexes consisting of multiple proteins regulate basic biological processes such as embryogenesis and, when disturbed, cause human disease. Our research investigates molecular mechanisms by which LIM domain proteins and associated cofactors regulate differential gene expression during cell fate specification events.

        The LIM domain mediates protein-protein interactions and is found in various proteins including LIM homeodomain transcription factors (LIM-HD), LIM-only (LMO) proteins and LIM kinases (LIMK). We are particularly interested in functions and regulation of LIM-HD proteins that specify cell lineages and regulate neuronal differentiation and brain morphogenesis during vertebrate and invertebrate development. The biological activity of LIM-HDs is regulated by LIM domain-associated cofactors CLIM/Lbd and RLIM/Rnf12. These cofactors are widely expressed and also exert important functions in the mammary gland and during X chromosome inactivation in female mice.

        To carry out our studies we apply molecular, biochemical and genetic methods using mouse development as model system. Current research projects in the laboratory comprise studies on the roles of LIM domain proteins / associated cofactors 1) for cell fate decisions during nervous system development, 2) for X chromosome inactivation, and 3) for mammary gland development, differentiation and breast cancer. Results of this research are intended to illuminate mechanisms of how cell fate decisions are orchestrated and how disturbances can lead to human disease.



        Rotation Projects

        Rotation Projects

        For rotation projects, please inquire with Dr. Bach.



        Post Docs

        A postdoctoral position is available to study in this laboratory. Contact Dr. Bach for additional details.

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Shin J, Wallingford MC, Gallant J, Marcho C, Jiao B, Byron M, Bossenz M, Lawrence JB, Jones SN, Mager J, Bach I. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature. 2014 Jul 3; 511(7507):86-9.
          View in: PubMed
        2. Jiao B, Taniguchi-Ishigaki N, Güngör C, Peters MA, Chen YW, Riethdorf S, Drung A, Ahronian LG, Shin J, Pagnis R, Pantel K, Tachibana T, Lewis BC, Johnsen SA, Bach I. Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling. Mol Biol Cell. 2013 Oct; 24(19):3085-96.
          View in: PubMed
        3. Bach I. Releasing the break on X chromosome inactivation: Rnf12/RLIM targets REX1 for degradation. Cell Res. 2012 Nov; 22(11):1524-6.
          View in: PubMed
        4. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell. 2012 Apr 27; 149(3):630-41.
          View in: PubMed
        5. Zhong Z, Ohnmacht J, Reimer MM, Bach I, Becker T, Becker CG. Chondrolectin mediates growth cone interactions of motor axons with an intermediate target. J Neurosci. 2012 Mar 28; 32(13):4426-39.
          View in: PubMed
        6. Subramanian L, Sarkar A, Shetty AS, Muralidharan B, Padmanabhan H, Piper M, Monuki ES, Bach I, Gronostajski RM, Richards LJ, Tole S. Transcription factor Lhx2 is necessary and sufficient to suppress astrogliogenesis and promote neurogenesis in the developing hippocampus. Proc Natl Acad Sci U S A. 2011 Jul 5; 108(27):E265-74.
          View in: PubMed
        7. Peter CJ, Evans M, Thayanithy V, Taniguchi-Ishigaki N, Bach I, Kolpak A, Bassell GJ, Rossoll W, Lorson CL, Bao ZZ, Androphy EJ. The COPI vesicle complex binds and moves with survival motor neuron within axons. Hum Mol Genet. 2011 May 1; 20(9):1701-11.
          View in: PubMed
        8. Zhong Z, Ma H, Taniguchi-Ishigaki N, Nagarajan L, Becker CG, Bach I, Becker T. SSDP cofactors regulate neural patterning and differentiation of specific axonal projections. Dev Biol. 2011 Jan 15; 349(2):213-24.
          View in: PubMed
        9. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81.
          View in: PubMed
        10. Johnsen SA, Güngör C, Prenzel T, Riethdorf S, Riethdorf L, Taniguchi-Ishigaki N, Rau T, Tursun B, Furlow JD, Sauter G, Scheffner M, Pantel K, Gannon F, Bach I. Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. Cancer Res. 2009 Jan 1; 69(1):128-36.
          View in: PubMed
        11. Bhati M, Lee C, Nancarrow AL, Lee M, Craig VJ, Bach I, Guss JM, Mackay JP, Matthews JM. Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes. EMBO J. 2008 Jul 23; 27(14):2018-29.
          View in: PubMed
        12. Bhati M, Lee M, Nancarrow AL, Bach I, Guss JM, Matthews JM. Crystallization of an Lhx3-Isl1 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Apr 1; 64(Pt 4):297-9.
          View in: PubMed
        13. Güngör C, Taniguchi-Ishigaki N, Ma H, Drung A, Tursun B, Ostendorff HP, Bossenz M, Becker CG, Becker T, Bach I. Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors. Proc Natl Acad Sci U S A. 2007 Sep 18; 104(38):15000-5.
          View in: PubMed
        14. Ostendorff HP, Tursun B, Cornils K, Schlüter A, Drung A, Güngör C, Bach I. Dynamic expression of LIM cofactors in the developing mouse neural tube. Dev Dyn. 2006 Mar; 235(3):786-91.
          View in: PubMed
        15. Lee C, Nancarrow AL, Bach I, Mackay JP, Matthews JM. 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex. J Biomol NMR. 2005 Nov; 33(3):198.
          View in: PubMed
        16. Tursun B, Schlüter A, Peters MA, Viehweger B, Ostendorff HP, Soosairajah J, Drung A, Bossenz M, Johnsen SA, Schweizer M, Bernard O, Bach I. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005 Oct 1; 19(19):2307-19.
          View in: PubMed
        17. Mollé B, Père S, Failli V, Bach I, Rétaux S. Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation. DNA Cell Biol. 2004 Nov; 23(11):761-8.
          View in: PubMed
        18. Krämer OH, Zhu P, Ostendorff HP, Golebiewski M, Tiefenbach J, Peters MA, Brill B, Groner B, Bach I, Heinzel T, Göttlicher M. The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J. 2003 Jul 1; 22(13):3411-20.
          View in: PubMed
        19. Bach I, Ostendorff HP. Orchestrating nuclear functions: ubiquitin sets the rhythm. Trends Biochem Sci. 2003 Apr; 28(4):189-95.
          View in: PubMed
        20. Becker T, Bossenz M, Tursun B, Schlüter A, Peters MA, Becker CG, Ostendorff HP, Bach I. Comparing protein stabilities during zebrafish embryogenesis. Methods Cell Sci. 2003; 25(1-2):85-9.
          View in: PubMed
        21. Gimnopoulos D, Becker CG, Ostendorff HP, Bach I, Schachner M, Becker T. Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains. Mech Dev. 2002 Dec; 119 Suppl 1:S135-41.
          View in: PubMed
        22. Becker T, Ostendorff HP, Bossenz M, Schlüter A, Becker CG, Peirano RI, Bach I. Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development. Mech Dev. 2002 Sep; 117(1-2):75-85.
          View in: PubMed
        23. Ostendorff HP, Peirano RI, Peters MA, Schlüter A, Bossenz M, Scheffner M, Bach I. Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors. Nature. 2002 Mar 7; 416(6876):99-103.
          View in: PubMed
        24. Ostendorff HP, Bossenz M, Mincheva A, Copeland NG, Gilbert DJ, Jenkins NA, Lichter P, Bach I. Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors. Genomics. 2000 Oct 1; 69(1):120-30.
          View in: PubMed
        25. Bach I. The LIM domain: regulation by association. Mech Dev. 2000 Mar 1; 91(1-2):5-17.
          View in: PubMed
        26. Bach I, Rodriguez-Esteban C, Carrière C, Bhushan A, Krones A, Rose DW, Glass CK, Andersen B, Izpisúa Belmonte JC, Rosenfeld MG. RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet. 1999 Aug; 22(4):394-9.
          View in: PubMed
        27. Rétaux S, Rogard M, Bach I, Failli V, Besson MJ. Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain. J Neurosci. 1999 Jan 15; 19(2):783-93.
          View in: PubMed
        28. Tucker AS, Al Khamis A, Ferguson CA, Bach I, Rosenfeld MG, Sharpe PT. Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development. 1999 Jan; 126(2):221-8.
          View in: PubMed
        29. Sugihara TM, Bach I, Kioussi C, Rosenfeld MG, Andersen B. Mouse deformed epidermal autoregulatory factor 1 recruits a LIM domain factor, LMO-4, and CLIM coregulators. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15418-23.
          View in: PubMed
        30. Bach I, Carrière C, Ostendorff HP, Andersen B, Rosenfeld MG. A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. Genes Dev. 1997 Jun 1; 11(11):1370-80.
          View in: PubMed
        31. Rosenfeld MG, Bach I, Erkman L, Li P, Lin C, Lin S, McEvilly R, Ryan A, Rhodes S, Schonnemann M, Scully K. Transcriptional control of cell phenotypes in the neuroendocrine system. Recent Prog Horm Res. 1996; 51:217-38; discussion 238-9.
          View in: PubMed
        32. Bach I, Rhodes SJ, Pearse RV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG. P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci U S A. 1995 Mar 28; 92(7):2720-4.
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        33. Bach I, Yaniv M. More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing. EMBO J. 1993 Nov; 12(11):4229-42.
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        34. Christova R, Bach I, Galcheva-Gargova Z. Sequences of DNA fragments contacting the nuclear lamina in vivo. DNA Cell Biol. 1992 Oct; 11(8):627-36.
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        35. Bach I, Pontoglio M, Yaniv M. Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1). Nucleic Acids Res. 1992 Aug 25; 20(16):4199-204.
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        36. Bach I, Mattei MG, Cereghini S, Yaniv M. Two members of an HNF1 homeoprotein family are expressed in human liver. Nucleic Acids Res. 1991 Jul 11; 19(13):3553-9.
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        37. Chouard T, Blumenfeld M, Bach I, Vandekerckhove J, Cereghini S, Yaniv M. A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. Nucleic Acids Res. 1990 Oct 11; 18(19):5853-63.
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        38. Bach I, Galcheva-Gargova Z, Mattei MG, Simon-Chazottes D, Guénet JL, Cereghini S, Yaniv M. Cloning of human hepatic nuclear factor 1 (HNF1) and chromosomal localization of its gene in man and mouse. Genomics. 1990 Sep; 8(1):155-64.
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        39. Tronche F, Rollier A, Herbomel P, Bach I, Cereghini S, Weiss M, Yaniv M. Anatomy of the rat albumin promoter. Mol Biol Med. 1990 Apr; 7(2):173-85.
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        40. Tronche F, Rollier A, Bach I, Weiss MC, Yaniv M. The rat albumin promoter: cooperation with upstream elements is required when binding of APF/HNF1 to the proximal element is partially impaired by mutation or bacterial methylation. Mol Cell Biol. 1989 Nov; 9(11):4759-66.
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