Apoptosis
"Apoptosis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Descriptor ID |
D017209
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MeSH Number(s) |
G04.299.139.160
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Concept/Terms |
Apoptosis- Apoptosis
- Programmed Cell Death, Type I
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Below are MeSH descriptors whose meaning is more general than "Apoptosis".
Below are MeSH descriptors whose meaning is more specific than "Apoptosis".
This graph shows the total number of publications written about "Apoptosis" by people in this website by year, and whether "Apoptosis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
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1992 | 1 | 0 | 1 | 1993 | 4 | 1 | 5 | 1994 | 6 | 1 | 7 | 1995 | 16 | 1 | 17 | 1996 | 10 | 8 | 18 | 1997 | 6 | 3 | 9 | 1998 | 11 | 6 | 17 | 1999 | 14 | 8 | 22 | 2000 | 12 | 7 | 19 | 2001 | 12 | 9 | 21 | 2002 | 31 | 20 | 51 | 2003 | 28 | 22 | 50 | 2004 | 14 | 26 | 40 | 2005 | 19 | 28 | 47 | 2006 | 26 | 26 | 52 | 2007 | 14 | 12 | 26 | 2008 | 15 | 25 | 40 | 2009 | 20 | 24 | 44 | 2010 | 14 | 28 | 42 | 2011 | 14 | 30 | 44 | 2012 | 14 | 22 | 36 | 2013 | 12 | 28 | 40 | 2014 | 22 | 22 | 44 | 2015 | 7 | 21 | 28 | 2016 | 5 | 7 | 12 | 2017 | 2 | 6 | 8 | 2018 | 1 | 4 | 5 | 2019 | 0 | 3 | 3 |
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Below are the most recent publications written about "Apoptosis" by people in Profiles.
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Wang JD, Katz SG, Morgan EA, Yang DT, Pan X, Xu ML. Proapoptotic protein BIM as a novel prognostic marker in mantle cell lymphoma. Hum Pathol. 2019 11; 93:54-64.
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Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KN. RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1. Blood. 2019 07 04; 134(1):59-73.
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Imran A, Butt MS, Xiao H, Imran M, Rauf A, Mubarak MS, Ramadan MF. Inhibitory effect of black tea (Camellia sinensis) theaflavins and thearubigins against HCT 116 colon cancer cells and HT 460 lung cancer cells. J Food Biochem. 2019 05; 43(5):e12822.
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Ruscetti M, Leibold J, Bott MJ, Fennell M, Kulick A, Salgado NR, Chen CC, Ho YJ, Sanchez-Rivera FJ, Feucht J, Baslan T, Tian S, Chen HA, Romesser PB, Poirier JT, Rudin CM, de Stanchina E, Manchado E, Sherr CJ, Lowe SW. NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination. Science. 2018 12 21; 362(6421):1416-1422.
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Sokolova M, Sahraoui A, Høyem M, Øgaard J, Lien E, Aukrust P, Yndestad A, Ranheim T, Scholz H. NLRP3 inflammasome mediates oxidative stress-induced pancreatic islet dysfunction. Am J Physiol Endocrinol Metab. 2018 11 01; 315(5):E912-E923.
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Li L, He M, Xiao H, Liu X, Wang K, Zhang Y. Acetic Acid Influences BRL-3A Cell Lipid Metabolism via the AMPK Signalling Pathway. Cell Physiol Biochem. 2018; 45(5):2021-2030.
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Gong J, Zheng Y, Wang Y, Sheng W, Li Y, Liu X, Si S, Shao R, Zhen Y. A new compound of thiophenylated pyridazinone IMB5043 showing potent antitumor efficacy through ATM-Chk2 pathway. PLoS One. 2018; 13(2):e0191984.
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Wu X, Song M, Qiu P, Li F, Wang M, Zheng J, Wang Q, Xu F, Xiao H. A metabolite of nobiletin, 4'-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by inducing G0/G1 cell cycle arrest and apoptosis. Food Funct. 2018 Jan 24; 9(1):87-95.
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Venkatesh A, Cheng SY, Punzo C. Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa. Mol Vis. 2017; 23:944-951.
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Saito Y, Mochizuki Y, Ogahara I, Watanabe T, Hogdal L, Takagi S, Sato K, Kaneko A, Kajita H, Uchida N, Fukami T, Shultz LD, Taniguchi S, Ohara O, Letai AG, Ishikawa F. Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways. Sci Transl Med. 2017 Oct 25; 9(413).
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