Header Logo

Robert M Kotin PhD

InstitutionUMass Chan Medical School
DepartmentMicrobiology and Physiological Systems
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
vCardDownload vCard
    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentMicrobiology and Physiological Systems

    Collapse Biography 
    Collapse education and training
    University of California, Santa Cruz, Santa Cruz, CA, United StatesBABiology
    Rutgers University- New Brunswick, New Brunswick, NJ, United StatesPHDMicrobiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Destro F, Joseph J, Srinivasan P, Kanter JM, Neufeld C, Wolfrum JM, Barone PW, Springs SL, Sinskey AJ, Cecchini S, Kotin RM, Braatz RD. Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system. Mol Ther Methods Clin Dev. 2023 Sep 14; 30:122-146. PMID: 37746245.
    2. Campbell MA, Loncar S, Kotin RM, Gifford RJ. Comparative analysis reveals the long-term coevolutionary history of parvoviruses and vertebrates. PLoS Biol. 2022 11; 20(11):e3001867. PMID: 36445931.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Hildebrandt E, Penzes JJ, Gifford RJ, Agbandje-Mckenna M, Kotin RM. Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors. Virus Evol. 2020 Jul; 6(2):veaa043. PMID: 32913662.
    4. Kotin RM, Wright JF. Recombinant Adeno-Associated Virus Quality Control for Non-Clinical and Clinical Vectors: How an Unregulated Commercial Sector Can Compromise Development of New Gene Therapies. Hum Gene Ther. 2019 12; 30(12):1447-1448. PMID: 31860397.
      Citations: 3     Fields:    Translation:HumansCells
    5. Kotin RM, Snyder RO. Manufacturing Clinical Grade Recombinant Adeno-Associated Virus Using Invertebrate Cell Lines. Hum Gene Ther. 2017 04; 28(4):350-360. PMID: 28351174.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    6. Smith RH, Hallwirth CV, Westerman M, Hetherington NA, Tseng YS, Cecchini S, Virag T, Ziegler ML, Rogozin IB, Koonin EV, Agbandje-McKenna M, Kotin RM, Alexander IE. Germline viral "fossils" guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus. Sci Rep. 2016 07 05; 6:28965. PMID: 27377618.
      Citations: 18     Fields:    Translation:AnimalsCells
    7. Choudhury SR, Fitzpatrick Z, Harris AF, Maitland SA, Ferreira JS, Zhang Y, Ma S, Sharma RB, Gray-Edwards HL, Johnson JA, Johnson AK, Alonso LC, Punzo C, Wagner KR, Maguire CA, Kotin RM, Martin DR, Sena-Esteves M. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther. 2016 08; 24(7):1247-57. PMID: 27117222.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    8. Le Guiner C, Montus M, Servais L, Cherel Y, Francois V, Thibaud JL, Wary C, Matot B, Larcher T, Guigand L, Dutilleul M, Domenger C, Allais M, Beuvin M, Moraux A, Le Duff J, Devaux M, Jaulin N, Guilbaud M, Latournerie V, Veron P, Boutin S, Leborgne C, Desgue D, Deschamps JY, Moullec S, Fromes Y, Vulin A, Smith RH, Laroudie N, Barnay-Toutain F, Rivi?re C, Bucher S, Le TH, Delaunay N, Gasmi M, Kotin RM, Bonne G, Adjali O, Masurier C, Hogrel JY, Carlier P, Moullier P, Voit T. Forelimb treatment in a large cohort of dystrophic dogs supports delivery of a recombinant AAV for exon skipping in Duchenne patients. Mol Ther. 2014 Nov; 22(11):1923-35. PMID: 25200009.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    9. Li L, Dimitriadis EK, Yang Y, Li J, Yuan Z, Qiao C, Beley C, Smith RH, Garcia L, Kotin RM. Production and characterization of novel recombinant adeno-associated virus replicative-form genomes: a eukaryotic source of DNA for gene transfer. PLoS One. 2013; 8(8):e69879. PMID: 23936358.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Airenne KJ, Hu YC, Kost TA, Smith RH, Kotin RM, Ono C, Matsuura Y, Wang S, Yl?-Herttuala S. Baculovirus: an insect-derived vector for diverse gene transfer applications. Mol Ther. 2013 Apr; 21(4):739-49. PMID: 23439502.
      Citations: 58     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Barbash IM, Cecchini S, Faranesh AZ, Virag T, Li L, Yang Y, Hoyt RF, Kornegay JN, Bogan JR, Garcia L, Lederman RJ, Kotin RM. MRI roadmap-guided transendocardial delivery of exon-skipping recombinant adeno-associated virus restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Gene Ther. 2013 Mar; 20(3):274-82. PMID: 22551778.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Denard J, Beley C, Kotin R, Lai-Kuen R, Blot S, Leh H, Asokan A, Samulski RJ, Moullier P, Voit T, Garcia L, Svinartchouk F. Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. J Virol. 2012 Jun; 86(12):6620-31. PMID: 22496229.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    13. H?ndel EM, Gellhaus K, Khan K, Bednarski C, Cornu TI, M?ller-Lerch F, Kotin RM, Heilbronn R, Cathomen T. Versatile and efficient genome editing in human cells by combining zinc-finger nucleases with adeno-associated viral vectors. Hum Gene Ther. 2012 Mar; 23(3):321-9. PMID: 21980922.
      Citations: 30     Fields:    Translation:HumansCells
    14. Bish LT, Sleeper MM, Forbes SC, Wang B, Reynolds C, Singletary GE, Trafny D, Morine KJ, Sanmiguel J, Cecchini S, Virag T, Vulin A, Beley C, Bogan J, Wilson JM, Vandenborne K, Kornegay JN, Walter GA, Kotin RM, Garcia L, Sweeney HL. Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping. Mol Ther. 2012 Mar; 20(3):580-9. PMID: 22146342.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    15. Cecchini S, Virag T, Kotin RM. Reproducible high yields of recombinant adeno-associated virus produced using invertebrate cells in 0.02- to 200-liter cultures. Hum Gene Ther. 2011 Aug; 22(8):1021-30. PMID: 21381980.
      Citations: 35     Fields:    Translation:AnimalsCells
    16. Kotin RM. Large-scale recombinant adeno-associated virus production. Hum Mol Genet. 2011 Apr 15; 20(R1):R2-6. PMID: 21531790.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    17. Virag T, Cecchini S, Kotin RM. Producing recombinant adeno-associated virus in foster cells: overcoming production limitations using a baculovirus-insect cell expression strategy. Hum Gene Ther. 2009 Aug; 20(8):807-17. PMID: 19604040.
      Citations: 35     Fields:    Translation:AnimalsCells
    18. Smith RH, Levy JR, Kotin RM. A simplified baculovirus-AAV expression vector system coupled with one-step affinity purification yields high-titer rAAV stocks from insect cells. Mol Ther. 2009 Nov; 17(11):1888-96. PMID: 19532142.
      Citations: 125     Fields:    Translation:AnimalsCells
    19. Cecchini S, Negrete A, Virag T, Graham BS, Cohen JI, Kotin RM. Evidence of prior exposure to human bocavirus as determined by a retrospective serological study of 404 serum samples from adults in the United States. Clin Vaccine Immunol. 2009 May; 16(5):597-604. PMID: 19244471.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    20. Negrete A, Kotin RM. Strategies for manufacturing recombinant adeno-associated virus vectors for gene therapy applications exploiting baculovirus technology. Brief Funct Genomic Proteomic. 2008 Jul; 7(4):303-11. PMID: 18632744.
      Citations: 7     Fields:    Translation:AnimalsCells
    21. Hsu PY, Kotin RM, Yang YW. Glucose- and metabolically regulated hepatic insulin gene therapy for diabetes. Pharm Res. 2008 Jun; 25(6):1460-8. PMID: 18293064.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Cecchini S, Negrete A, Kotin RM. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Ther. 2008 Jun; 15(11):823-30. PMID: 18401433.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    23. Smith RH, Yang L, Kotin RM. Chromatography-based purification of adeno-associated virus. Methods Mol Biol. 2008; 434:37-54. PMID: 18470638.
      Citations: 6     Fields:    Translation:HumansCells
    24. Negrete A, Kotin RM. Large-scale production of recombinant adeno-associated viral vectors. Methods Mol Biol. 2008; 433:79-96. PMID: 18679618.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    25. Negrete A, Yang LC, Mendez AF, Levy JR, Kotin RM. Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system. J Gene Med. 2007 Nov; 9(11):938-48. PMID: 17764098.
      Citations: 22     Fields:    Translation:AnimalsCells
    26. Szerlip NJ, Walbridge S, Yang L, Morrison PF, Degen JW, Jarrell ST, Kouri J, Kerr PB, Kotin R, Oldfield EH, Lonser RR. Real-time imaging of convection-enhanced delivery of viruses and virus-sized particles. J Neurosurg. 2007 Sep; 107(3):560-7. PMID: 17886556.
      Citations: 51     Fields:    Translation:AnimalsCells
    27. Negrete A, Esteban G, Kotin RM. Process optimization of large-scale production of recombinant adeno-associated vectors using dielectric spectroscopy. Appl Microbiol Biotechnol. 2007 Sep; 76(4):761-72. PMID: 17680241.
      Citations: 8     Fields:    Translation:AnimalsCells
    28. Negrete A, Kotin RM. Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales. J Virol Methods. 2007 Nov; 145(2):155-61. PMID: 17606302.
      Citations: 9     Fields:    Translation:Cells
    29. Schirmer JM, Miyagi N, Rao VP, Ricci D, Federspiel MJ, Kotin RM, Russell SJ, McGregor CG. Recombinant adeno-associated virus vector for gene transfer to the transplanted rat heart. Transpl Int. 2007 Jun; 20(6):550-7. PMID: 17403107.
      Citations: 8     Fields:    Translation:AnimalsCellsCTClinical Trials
    30. Li L, Yang L, Scudiero DA, Miller SA, Yu ZX, Stukenberg PT, Shoemaker RH, Kotin RM. Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells. Gene Ther. 2007 May; 14(10):814-27. PMID: 17330085.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    31. Thorsen F, Afione S, Huszthy PC, Tysnes BB, Svendsen A, Bjerkvig R, Kotin RM, L?nning PE, Hoover F. Adeno-associated virus (AAV) serotypes 2, 4 and 5 display similar transduction profiles and penetrate solid tumor tissue in models of human glioma. J Gene Med. 2006 Sep; 8(9):1131-40. PMID: 16810631.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    32. Urabe M, Nakakura T, Xin KQ, Obara Y, Mizukami H, Kume A, Kotin RM, Ozawa K. Scalable generation of high-titer recombinant adeno-associated virus type 5 in insect cells. J Virol. 2006 Feb; 80(4):1874-85. PMID: 16439543.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    33. Li W, Yu ZX, Kotin RM. Profiles of PrKX expression in developmental mouse embryo and human tissues. J Histochem Cytochem. 2005 Aug; 53(8):1003-9. PMID: 15879576.
      Citations: 10     Fields:    Translation:HumansAnimals
    34. Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5820-5. PMID: 15811941.
      Citations: 295     Fields:    Translation:HumansAnimalsCells
    35. Li L, Yang L, Kotin RM. The DNA minor groove binding agents Hoechst 33258 and 33342 enhance recombinant adeno-associated virus (rAAV) transgene expression. J Gene Med. 2005 Apr; 7(4):420-31. PMID: 15538728.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Huszthy PC, Svendsen A, Wilson JM, Kotin RM, L?nning PE, Bjerkvig R, Hoover F. Widespread dispersion of adeno-associated virus serotype 1 and adeno-associated virus serotype 6 vectors in the rat central nervous system and in human glioblastoma multiforme xenografts. Hum Gene Ther. 2005 Mar; 16(3):381-92. PMID: 15812233.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    37. Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, Paulson HL, Yang L, Kotin RM, Davidson BL. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med. 2004 Aug; 10(8):816-20. PMID: 15235598.
      Citations: 231     Fields:    Translation:AnimalsCells
    38. Hickman AB, Ronning DR, Perez ZN, Kotin RM, Dyda F. The nuclease domain of adeno-associated virus rep coordinates replication initiation using two distinct DNA recognition interfaces. Mol Cell. 2004 Feb 13; 13(3):403-14. PMID: 14967147.
      Citations: 61     Fields:    Translation:HumansCells
    39. Smith RH, Ding C, Kotin RM. Serum-free production and column purification of adeno-associated virus type 5. J Virol Methods. 2003 Dec; 114(2):115-24. PMID: 14625046.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    40. Lotery AJ, Yang GS, Mullins RF, Russell SR, Schmidt M, Stone EM, Lindbloom JD, Chiorini JA, Kotin RM, Davidson BL. Adeno-associated virus type 5: transduction efficiency and cell-type specificity in the primate retina. Hum Gene Ther. 2003 Nov 20; 14(17):1663-71. PMID: 14633408.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    41. Yang GS, Schmidt M, Yan Z, Lindbloom JD, Harding TC, Donahue BA, Engelhardt JF, Kotin R, Davidson BL. Virus-mediated transduction of murine retina with adeno-associated virus: effects of viral capsid and genome size. J Virol. 2002 Aug; 76(15):7651-60. PMID: 12097579.
      Citations: 71     Fields:    Translation:AnimalsCells
    42. Mastakov MY, Baer K, Symes CW, Leichtlein CB, Kotin RM, During MJ. Immunological aspects of recombinant adeno-associated virus delivery to the mammalian brain. J Virol. 2002 Aug; 76(16):8446-54. PMID: 12134047.
      Citations: 43     Fields:    Translation:AnimalsCells
    43. Smith RH, Afione SA, Kotin RM. Transposase-mediated construction of an integrated adeno-associated virus type 5 helper plasmid. Biotechniques. 2002 Jul; 33(1):204-6, 208, 210-1. PMID: 12139247.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    44. Mastakov MY, Baer K, Kotin RM, During MJ. Recombinant adeno-associated virus serotypes 2- and 5-mediated gene transfer in the mammalian brain: quantitative analysis of heparin co-infusion. Mol Ther. 2002 Apr; 5(4):371-80. PMID: 11945063.
      Citations: 18     Fields:    Translation:AnimalsCells
    45. Schmidt M, Chiorini JA, Afione S, Kotin R. Adeno-associated virus type 2 Rep78 inhibition of PKA and PRKX: fine mapping and analysis of mechanism. J Virol. 2002 Feb; 76(3):1033-42. PMID: 11773379.
      Citations: 7     Fields:    Translation:HumansCells
    46. Yamano S, Huang LY, Ding C, Chiorini JA, Goldsmith CM, Wellner RB, Golding B, Kotin RM, Scott DE, Baum BJ. Recombinant adeno-associated virus serotype 2 vectors mediate stable interleukin 10 secretion from salivary glands into the bloodstream. Hum Gene Ther. 2002 Jan 20; 13(2):287-98. PMID: 11812284.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    47. Ding C, Urabe M, Bergoin M, Kotin RM. Biochemical characterization of Junonia coenia densovirus nonstructural protein NS-1. J Virol. 2002 Jan; 76(1):338-45. PMID: 11739698.
      Citations: 15     Fields:    Translation:Cells
    48. Schmidt M, Afione S, Kotin RM. Adeno-associated virus type 2 Rep78 induces apoptosis through caspase activation independently of p53. J Virol. 2000 Oct; 74(20):9441-50. PMID: 11000213.
      Citations: 50     Fields:    Translation:HumansCells
    49. Yang YW, Kotin RM. Glucose-responsive gene delivery in pancreatic Islet cells via recombinant adeno-associated viral vectors. Pharm Res. 2000 Sep; 17(9):1056-61. PMID: 11087036.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    50. Zabner J, Seiler M, Walters R, Kotin RM, Fulgeras W, Davidson BL, Chiorini JA. Adeno-associated virus type 5 (AAV5) but not AAV2 binds to the apical surfaces of airway epithelia and facilitates gene transfer. J Virol. 2000 Apr; 74(8):3852-8. PMID: 10729159.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    51. Smith RH, Kotin RM. An adeno-associated virus (AAV) initiator protein, Rep78, catalyzes the cleavage and ligation of single-stranded AAV ori DNA. J Virol. 2000 Apr; 74(7):3122-9. PMID: 10708427.
      Citations: 30     Fields:    Translation:Cells
    52. Davidson BL, Stein CS, Heth JA, Martins I, Kotin RM, Derksen TA, Zabner J, Ghodsi A, Chiorini JA. Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3428-32. PMID: 10688913.
      Citations: 236     Fields:    Translation:AnimalsCells
    53. Chiorini JA, Afione S, Kotin RM. Adeno-associated virus (AAV) type 5 Rep protein cleaves a unique terminal resolution site compared with other AAV serotypes. J Virol. 1999 May; 73(5):4293-8. PMID: 10196327.
      Citations: 29     Fields:    Translation:HumansCells
    54. Zimmermann B, Chiorini JA, Ma Y, Kotin RM, Herberg FW. PrKX is a novel catalytic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I. J Biol Chem. 1999 Feb 26; 274(9):5370-8. PMID: 10026146.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    55. Chiorini JA, Kim F, Yang L, Kotin RM. Cloning and characterization of adeno-associated virus type 5. J Virol. 1999 Feb; 73(2):1309-19. PMID: 9882336.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    56. Braddon VR, Chiorini JA, Wang S, Kotin RM, Baum BJ. Adenoassociated virus-mediated transfer of a functional water channel into salivary epithelial cells in vitro and in vivo. Hum Gene Ther. 1998 Dec 10; 9(18):2777-85. PMID: 9874275.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    57. Chiorini JA, Zimmermann B, Yang L, Smith RH, Ahearn A, Herberg F, Kotin RM. Inhibition of PrKX, a novel protein kinase, and the cyclic AMP-dependent protein kinase PKA by the regulatory proteins of adeno-associated virus type 2. Mol Cell Biol. 1998 Oct; 18(10):5921-9. PMID: 9742109.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    58. Smith RH, Kotin RM. The Rep52 gene product of adeno-associated virus is a DNA helicase with 3'-to-5' polarity. J Virol. 1998 Jun; 72(6):4874-81. PMID: 9573254.
      Citations: 51     Fields:    Translation:Cells
    59. Maass G, Bogedain C, Scheer U, Michl D, H?rer M, Braun-Falco M, Volkenandt M, Schadendorf D, Wendtner CM, Winnacker EL, Kotin RM, Hallek M. Recombinant adeno-associated virus for the generation of autologous, gene-modified tumor vaccines: evidence for a high transduction efficiency into primary epithelial cancer cells. Hum Gene Ther. 1998 May 01; 9(7):1049-59. PMID: 9607416.
      Citations: 1     Fields:    Translation:HumansCells
    60. Chiorini JA, Yang L, Liu Y, Safer B, Kotin RM. Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol. 1997 Sep; 71(9):6823-33. PMID: 9261407.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    61. Wendtner CM, Nolte A, Mangold E, Buhmann R, Maass G, Chiorini JA, Winnacker EL, Emmerich B, Kotin RM, Hallek M. Gene transfer of the costimulatory molecules B7-1 and B7-2 into human multiple myeloma cells by recombinant adeno-associated virus enhances the cytolytic T cell response. Gene Ther. 1997 Jul; 4(7):726-35. PMID: 9282174.
      Citations: 2     Fields:    Translation:HumansCells
    62. Smith RH, Spano AJ, Kotin RM. The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences. J Virol. 1997 Jun; 71(6):4461-71. PMID: 9151837.
      Citations: 49     Fields:    Translation:Cells
    63. Chiorini JA, Wiener SM, Yang L, Smith RH, Safer B, Kilcoin NP, Liu Y, Urcelay E, Kotin RM. The roles of AAV Rep proteins in gene expression and targeted integration. Curr Top Microbiol Immunol. 1996; 218:25-33. PMID: 8794243.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    64. Chiorini JA, Wendtner CM, Urcelay E, Safer B, Hallek M, Kotin RM. High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Hum Gene Ther. 1995 Dec; 6(12):1531-41. PMID: 8664378.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    65. Chiorini JA, Yang L, Safer B, Kotin RM. Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. J Virol. 1995 Nov; 69(11):7334-8. PMID: 7474165.
      Citations: 34     Fields:    Translation:Cells
    66. Urcelay E, Ward P, Wiener SM, Safer B, Kotin RM. Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. J Virol. 1995 Apr; 69(4):2038-46. PMID: 7884849.
      Citations: 73     Fields:    Translation:HumansCells
    67. Chiorini JA, Wiener SM, Owens RA, Ky?sti? SR, Kotin RM, Safer B. Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. J Virol. 1994 Nov; 68(11):7448-57. PMID: 7933128.
      Citations: 66     Fields:    Translation:Cells
    68. Batchu RB, Kotin RM, Hermonat PL. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Lett. 1994 Oct 28; 86(1):23-31. PMID: 7954351.
      Citations: 11     Fields:    Translation:Cells
    69. Ward P, Urcelay E, Kotin R, Safer B, Berns KI. Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein. J Virol. 1994 Sep; 68(9):6029-37. PMID: 8057478.
      Citations: 36     Fields:    Translation:HumansCells
    70. Kotin RM. Prospects for the use of adeno-associated virus as a vector for human gene therapy. Hum Gene Ther. 1994 Jul; 5(7):793-801. PMID: 7981305.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    71. Weitzman MD, Ky?sti? SR, Kotin RM, Owens RA. Adeno-associated virus (AAV) Rep proteins mediate complex formation between AAV DNA and its integration site in human DNA. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5808-12. PMID: 8016070.
      Citations: 140     Fields:    Translation:HumansCells
    72. Chiorini JA, Weitzman MD, Owens RA, Urcelay E, Safer B, Kotin RM. Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. J Virol. 1994 Feb; 68(2):797-804. PMID: 8289383.
      Citations: 59     Fields:    Translation:HumansCells
    73. Kotin RM, Linden RM, Berns KI. Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. EMBO J. 1992 Dec; 11(13):5071-8. PMID: 1334463.
      Citations: 195     Fields:    Translation:HumansCells
    74. Kotin RM, Menninger JC, Ward DC, Berns KI. Mapping and direct visualization of a region-specific viral DNA integration site on chromosome 19q13-qter. Genomics. 1991 Jul; 10(3):831-4. PMID: 1653762.
      Citations: 114     Fields:    Translation:HumansCells
    75. Kotin RM, Siniscalco M, Samulski RJ, Zhu XD, Hunter L, Laughlin CA, McLaughlin S, Muzyczka N, Rocchi M, Berns KI. Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2211-5. PMID: 2156265.
      Citations: 311     Fields:    Translation:HumansCells
    76. Kotin RM, Berns KI. Organization of adeno-associated virus DNA in latently infected Detroit 6 cells. Virology. 1989 Jun; 170(2):460-7. PMID: 2543124.
      Citations: 52     Fields:    Translation:HumansCells
    77. Berns KI, Kotin RM, Labow MA. Regulation of adeno-associated virus DNA replication. Biochim Biophys Acta. 1988 Dec 20; 951(2-3):425-9. PMID: 2850017.
      Citations: 16     Fields:    Translation:Cells
    78. Fink AL, Kar D, Kotin R. Ribonuclease structure and catalysis: effects of crystalline enzyme, alcohol cryosolvents, low temperatures, and product inhibition. Biochemistry. 1987 Dec 29; 26(26):8571-9. PMID: 3442677.
      Citations: 1     Fields:    Translation:Cells
    79. Prince DL, Kotin RM, Dubin DT. Evidence that the methylation inhibitor cycloleucine causes accumulation of a discrete ribosomal RNA precursor in hamster mitochondria. Mol Biol Rep. 1986; 11(1):51-5. PMID: 3633018.
      Citations: 4     Fields:    Translation:AnimalsCells
    80. HsuChen CC, Kotin RM, Dubin DT. Sequences of the coding and flanking regions of the large ribosomal subunit RNA gene of mosquito mitochondria. Nucleic Acids Res. 1984 Oct 25; 12(20):7771-85. PMID: 6093053.
      Citations: 27     Fields:    Translation:AnimalsCells
    81. Kotin RM, Dubin DT. Sequences around the 3'-end of a ribosomal RNA gene of hamster mitochondria. Further support for the 'transcriptional attenuation' model. Biochim Biophys Acta. 1984 May 15; 782(1):106-8. PMID: 6722155.
      Citations: 3     Fields:    Translation:AnimalsCells
    Kotin's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (369)
    Co-Authors (3)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors