Endogenous Retroviruses

"Endogenous Retroviruses" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Retroviruses that have integrated into the germline (PROVIRUSES) that have lost infectious capability but retained the capability to transpose.

Descriptor ID	D020077
MeSH Number(s)	B04.613.807.250 B04.820.650.250 G02.111.570.080.708.330.800.175 G05.360.080.708.330.800.175 G05.360.340.024.425.800.175
Concept/Terms	Endogenous Retroviruses Endogenous Retroviruses ERVs Retroviruses, Endogenous Endogenous Retrovirus Retrovirus, Endogenous Human Endogenous Retroviruses Human Endogenous Retroviruses Endogenous Retrovirus, Human Endogenous Retroviruses, Human Human Endogenous Retrovirus Retrovirus, Human Endogenous Retroviruses, Human Endogenous HERVs

Below are MeSH descriptors whose meaning is more general than "Endogenous Retroviruses".

Organisms [B]
Viruses [B04]
Oncogenic Viruses [B04.613]
Retroviridae [B04.613.807]
Endogenous Retroviruses [B04.613.807.250]
RNA Viruses [B04.820]
Retroviridae [B04.820.650]
Endogenous Retroviruses [B04.820.650.250]
Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
Repetitive Sequences, Nucleic Acid [G02.111.570.080.708]
Interspersed Repetitive Sequences [G02.111.570.080.708.330]
Retroelements [G02.111.570.080.708.330.800]
Endogenous Retroviruses [G02.111.570.080.708.330.800.175]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Repetitive Sequences, Nucleic Acid [G05.360.080.708]
Interspersed Repetitive Sequences [G05.360.080.708.330]
Retroelements [G05.360.080.708.330.800]
Endogenous Retroviruses [G05.360.080.708.330.800.175]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Interspersed Repetitive Sequences [G05.360.340.024.425]
Retroelements [G05.360.340.024.425.800]
Endogenous Retroviruses [G05.360.340.024.425.800.175]

Below are MeSH descriptors whose meaning is related to "Endogenous Retroviruses".

Below are MeSH descriptors whose meaning is more specific than "Endogenous Retroviruses".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Endogenous Retroviruses" by people in this website by year, and whether "Endogenous Retroviruses" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 2 publications in 2012 and 2024 and 2025

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2012	2	0	2
2015	1	0	1
2020	1	0	1
2021	1	0	1
2024	1	1	2
2025	1	1	2

Below are the most recent publications written about "Endogenous Retroviruses" by people in Profiles.

Liu Z, Tan Y, Flynn WF, Sun L, Pratumkaew P, Alcoforado Diniz J, Oliveira NAJ, McDonough JA, Skarnes WC, Robson P. HAND1, partially mediated through ape-specific LTR binding, is essential for human extra-embryonic mesenchyme derivation from iPSCs. Cell Rep. 2025 Apr 22; 44(4):115568.

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Yu T, Blyton MBJ, Abajorga M, Koppetsch BS, Ho S, Xu B, Hu Z, Luban J, Chappell K, Weng Z, Theurkauf WE. Evolution of KoRV-A transcriptional silencing in wild koalas. Cell. 2025 Apr 17; 188(8):2081-2093.e16.

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Abajorga M, Yurkovetskiy L, Luban J. piRNA Defense Against Endogenous Retroviruses. Viruses. 2024 Nov 09; 16(11).

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Manakhov AD, Aarakelyan NA, Lapteacru AV, Andreeva TV, Trapezov OV, Rogaev EI. Genomic analysis links the American mink Royal pastel coat phenotype to retroviral element type 1 insertion in the HPS3 gene. Anim Genet. 2024 Oct; 55(5):788-792.

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Stearrett N, Dawson T, Rahnavard A, Bachali P, Bendall ML, Zeng C, Caricchio R, P?rez-Losada M, Grammer AC, Lipsky PE, Crandall KA. Expression of Human Endogenous Retroviruses in Systemic Lupus Erythematosus: Multiomic Integration With Gene Expression. Front Immunol. 2021; 12:661437.

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Dembny P, Newman AG, Singh M, Hinz M, Szczepek M, Kr?ger C, Adalbert R, Dzaye O, Trimbuch T, Wallach T, Kleinau G, Derkow K, Richard BC, Schipke C, Scheidereit C, Stachelscheid H, Golenbock D, Peters O, Coleman M, Heppner FL, Scheerer P, Tarabykin V, Ruprecht K, Izsv?k Z, Mayer J, Lehnardt S. Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors. JCI Insight. 2020 04 09; 5(7).

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Diehl WE, Patel N, Halm K, Johnson WE. Tracking interspecies transmission and long-term evolution of an ancient retrovirus using the genomes of modern mammals. Elife. 2016 Mar 08; 5:e12704.

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Brown RH, Al-Chalabi A. Endogenous retroviruses in ALS: A reawakening? Sci Transl Med. 2015 Sep 30; 7(307):307fs40.

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Diehl WE, Johnson WE, Hunter E. Elevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation. PLoS One. 2013; 8(3):e58532.

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Santoni FA, Guerra J, Luban J. HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency. Retrovirology. 2012 Dec 20; 9:111.

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