Cyclin-Dependent Kinase 5

"Cyclin-Dependent Kinase 5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.

Descriptor ID	D051360
MeSH Number(s)	D08.811.913.696.620.682.700.646.500.500.500 D12.644.360.250.067.875 D12.776.167.200.067.875 D12.776.476.250.067.875
Concept/Terms	Cyclin-Dependent Kinase 5 Cyclin-Dependent Kinase 5 Cyclin Dependent Kinase 5 Neuronal Cdc2-Like Protein Kinase Neuronal Cdc2 Like Protein Kinase Cdk5 Protein Kinase Protein Kinase, Cdk5 Cdk5 Protein PSSALRE Protein Cdc2-Related Kinase PSSALRE Cdc2 Related Kinase PSSALRE PSSALRE, Cdc2-Related Kinase

Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 5".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Proline-Directed Protein Kinases [D08.811.913.696.620.682.700.646]
Cyclin-Dependent Kinases [D08.811.913.696.620.682.700.646.500]
CDC2-CDC28 Kinases [D08.811.913.696.620.682.700.646.500.500]
Cyclin-Dependent Kinase 5 [D08.811.913.696.620.682.700.646.500.500.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Cyclin-Dependent Kinases [D12.644.360.250]
CDC2-CDC28 Kinases [D12.644.360.250.067]
Cyclin-Dependent Kinase 5 [D12.644.360.250.067.875]
Proteins [D12.776]
Cell Cycle Proteins [D12.776.167]
Cyclin-Dependent Kinases [D12.776.167.200]
CDC2-CDC28 Kinases [D12.776.167.200.067]
Cyclin-Dependent Kinase 5 [D12.776.167.200.067.875]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Cyclin-Dependent Kinases [D12.776.476.250]
CDC2-CDC28 Kinases [D12.776.476.250.067]
Cyclin-Dependent Kinase 5 [D12.776.476.250.067.875]

Below are MeSH descriptors whose meaning is related to "Cyclin-Dependent Kinase 5".

Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Cyclin-Dependent Kinase 5" by people in this website by year, and whether "Cyclin-Dependent Kinase 5" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2002 and 2006 and 2007 and 2008 and 2015 and 2019 and 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2006	1	0	1
2007	0	1	1
2008	1	0	1
2015	0	1	1
2019	0	1	1
2020	1	0	1

Below are the most recent publications written about "Cyclin-Dependent Kinase 5" by people in Profiles.

Xue J, Zhang L, Xie X, Gao Y, Jiang L, Wang J, Wang Y, Gao R, Yu J, Xiao H. Prenatal bisphenol A exposure contributes to Tau pathology: Potential roles of CDK5/GSK3?/PP2A axis in BPA-induced neurotoxicity. Toxicology. 2020 05 30; 438:152442.

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Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Bu?e L, Heneka MT. NLRP3 inflammasome activation drives tau pathology. Nature. 2019 11; 575(7784):669-673.

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Fl?ttmann R, Wagner J, Kobus K, Curry CJ, Savarirayan R, Nishimura G, Yasui N, Spranger J, Van Esch H, Lyons MJ, DuPont BR, Dwivedi A, Klopocki E, Horn D, Mundlos S, Spielmann M. Microdeletions on 6p22.3 are associated with mesomelic dysplasia Savarirayan type. J Med Genet. 2015 Jul; 52(7):476-83.

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Bianchetta MJ, Lam TT, Jones SN, Morabito MA. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J Neurosci. 2011 Aug 17; 31(33):12029-35.

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Kim D, Frank CL, Dobbin MM, Tsunemoto RK, Tu W, Peng PL, Guan JS, Lee BH, Moy LY, Giusti P, Broodie N, Mazitschek R, Delalle I, Haggarty SJ, Neve RL, Lu Y, Tsai LH. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron. 2008 Dec 10; 60(5):803-17.

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Zhang S, Edelmann L, Liu J, Crandall JE, Morabito MA. Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors. J Neurosci. 2008 Jan 09; 28(2):415-24.

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Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J. 2007 Jul 11; 26(13):3169-79.

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Cruz JC, Kim D, Moy LY, Dobbin MM, Sun X, Bronson RT, Tsai LH. p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo. J Neurosci. 2006 Oct 11; 26(41):10536-41.

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Morabito MA, Sheng M, Tsai LH. Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci. 2004 Jan 28; 24(4):865-76.

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Patzke H, Maddineni U, Ayala R, Morabito M, Volker J, Dikkes P, Ahlijanian MK, Tsai LH. Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene. J Neurosci. 2003 Apr 01; 23(7):2769-78.

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