"Motor Neuron Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Descriptor ID |
D016472
|
MeSH Number(s) |
C10.574.562 C10.668.467
|
Concept/Terms |
Motor Neuron Disease- Motor Neuron Disease
- Motor Neuron Diseases
- Neuron Disease, Motor
- Neuron Diseases, Motor
- Motor System Disease
- Motor System Diseases
Lateral Sclerosis- Lateral Sclerosis
- Lateral Scleroses
- Scleroses, Lateral
- Sclerosis, Lateral
- Primary Lateral Sclerosis
- Lateral Scleroses, Primary
- Lateral Sclerosis, Primary
- Primary Lateral Scleroses
- Scleroses, Primary Lateral
- Sclerosis, Primary Lateral
|
Below are MeSH descriptors whose meaning is more general than "Motor Neuron Disease".
Below are MeSH descriptors whose meaning is more specific than "Motor Neuron Disease".
This graph shows the total number of publications written about "Motor Neuron Disease" by people in this website by year, and whether "Motor Neuron Disease" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
---|
1998 | 1 | 0 | 1 |
2002 | 4 | 0 | 4 |
2003 | 1 | 0 | 1 |
2004 | 1 | 1 | 2 |
2005 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2007 | 3 | 2 | 5 |
2008 | 2 | 0 | 2 |
2009 | 0 | 1 | 1 |
2010 | 2 | 0 | 2 |
2015 | 1 | 0 | 1 |
2019 | 2 | 0 | 2 |
2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Motor Neuron Disease" by people in Profiles.
-
Ghasemi M, Poulliot K, Daniello KM, Silver B. Experience with telemedicine in neuromuscular clinic during COVID-19 pandemic. Acta Myol. 2023; 42(1):14-23.
-
Amin ND, Senturk G, Costaguta G, Driscoll S, O'Leary B, Bonanomi D, Pfaff SL. A hidden threshold in motor neuron gene networks revealed by modulation of miR-218 dose. Neuron. 2021 10 20; 109(20):3252-3267.e6.
-
McCall AL, ElMallah MK. Macroglossia, Motor Neuron Pathology, and Airway Malacia Contribute to Respiratory Insufficiency in Pompe Disease: A Commentary on Molecular Pathways and Respiratory Involvement in Lysosomal Storage Diseases. Int J Mol Sci. 2019 Feb 11; 20(3).
-
Sawalha K, Gonzalez-Toledo E, Hussein O. Role of Magnetic Resonance Imaging in Diagnosis of Motor Neuron Disease: Literature Review and Two Case Illustrations. Perm J. 2019; 23.
-
Brown RH, Al-Chalabi A. Endogenous retroviruses in ALS: A reawakening? Sci Transl Med. 2015 Sep 30; 7(307):307fs40.
-
Bucher T, Colle MA, Wakeling E, Dubreil L, Fyfe J, Briot-Nivard D, Maquigneau M, Raoul S, Cherel Y, Astord S, Duque S, Marais T, Voit T, Moullier P, Barkats M, Joussemet B. scAAV9 intracisternal delivery results in efficient gene transfer to the central nervous system of a feline model of motor neuron disease. Hum Gene Ther. 2013 Jul; 24(7):670-82.
-
Barbagallo B, Prescott HA, Boyle P, Climer J, Francis MM. A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans. J Neurosci. 2010 Oct 20; 30(42):13932-42.
-
Lemmens R, Moore MJ, Al-Chalabi A, Brown RH, Robberecht W. RNA metabolism and the pathogenesis of motor neuron diseases. Trends Neurosci. 2010 May; 33(5):249-58.
-
Salameh JS, Shenoy AM, David WS. Novel SPG3A and SPG4 mutations in two patients with Silver syndrome. J Clin Neuromuscul Dis. 2009 Sep; 11(1):57-9.
-
Duque S, Joussemet B, Riviere C, Marais T, Dubreil L, Douar AM, Fyfe J, Moullier P, Colle MA, Barkats M. Intravenous administration of self-complementary AAV9 enables transgene delivery to adult motor neurons. Mol Ther. 2009 Jul; 17(7):1187-96.