"Spinal Dysraphism" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)
Descriptor ID |
D016135
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MeSH Number(s) |
C10.500.680.800 C16.131.666.680.800
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Concept/Terms |
Spinal Dysraphism- Spinal Dysraphism
- Dysraphism, Spinal
- Dysraphisms, Spinal
- Spinal Dysraphisms
- Open Spine
- Open Spines
- Spine, Open
- Cleft Spine
- Cleft Spines
- Spine, Cleft
- Spina Bifida
- Bifida, Spina
- Spina Bifidas
- Schistorrhachis
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Below are MeSH descriptors whose meaning is more general than "Spinal Dysraphism".
Below are MeSH descriptors whose meaning is more specific than "Spinal Dysraphism".
This graph shows the total number of publications written about "Spinal Dysraphism" by people in this website by year, and whether "Spinal Dysraphism" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2004 | 1 | 0 | 1 |
2005 | 1 | 0 | 1 |
2007 | 1 | 1 | 2 |
2015 | 1 | 0 | 1 |
2017 | 2 | 0 | 2 |
2018 | 2 | 0 | 2 |
2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Spinal Dysraphism" by people in Profiles.
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Butler KM, Fee T, DuPont BR, Dean JH, Stevenson RE, Lyons MJ. A SOX3 duplication and lumbosacral spina bifida in three generations. Am J Med Genet A. 2022 05; 188(5):1572-1577.
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De Castro SCP, Gustavsson P, Marshall AR, Gordon WM, Galea G, Nikolopoulou E, Savery D, Rolo A, Stanier P, Andersen B, Copp AJ, Greene NDE. Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice. Hum Mol Genet. 2018 12 15; 27(24):4218-4230.
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Orriss IR, Lanham S, Savery D, Greene NDE, Stanier P, Oreffo R, Copp AJ, Galea GL. Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice. Sci Rep. 2018 02 20; 8(1):3325.
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Polfuss M, Sawin KJ, Papanek PE, Bandini L, Forseth B, Moosreiner A, Zvara K, Schoeller DA. Total energy expenditure and body composition of children with developmental disabilities. Disabil Health J. 2018 07; 11(3):442-446.
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Polfuss M, Bandini LG, Sawin KJ. Obesity Prevention for Individuals with Spina Bifida. Curr Obes Rep. 2017 Jun; 6(2):116-126.
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Tirumani SB, Mudunoor VK, Aemjal SC, Tirumani H, Rohatgi S. Ossified dysraphic hamartoma with lipomyelocoele/lipomyelomeningocoele-A rare radiological entity. Clin Imaging. 2017 May - Jun; 43:60-63.
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Hubert K, Sideridis G, Sherlock R, Queally J, Rosoklija I, Kringle G, Johnson K, Nurko S, Bauer S. Validation of a bowel dysfunction instrument for adolescents with spina bifida. J Pediatr Urol. 2015 Aug; 11(4):199.e1-7.
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Nicholls EG, Arango-Lasprilla JC, Olivera Plaza SL, Mendez N, Quintero L, Velasco Trujillo DM, Daly BP. Psychological Functioning in Youth With Spina Bifida Living in Colombia, South America. J Pediatr Psychol. 2015 Jul; 40(6):602-8.
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Wong RL, Wlodarczyk BJ, Min KS, Scott ML, Kartiko S, Yu W, Merriweather MY, Vogel P, Zambrowicz BP, Finnell RH. Mouse Fkbp8 activity is required to inhibit cell death and establish dorso-ventral patterning in the posterior neural tube. Hum Mol Genet. 2008 Feb 15; 17(4):587-601.
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Gustavsson P, Greene ND, Lad D, Pauws E, de Castro SC, Stanier P, Copp AJ. Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model. Hum Mol Genet. 2007 Nov 01; 16(21):2640-6.