Silent Information Regulator Proteins, Saccharomyces cerevisiae

"Silent Information Regulator Proteins, Saccharomyces cerevisiae" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A set of nuclear proteins in SACCHAROMYCES CEREVISIAE that are required for the transcriptional repression of the silent mating type loci. They mediate the formation of silenced CHROMATIN and repress both transcription and recombination at other loci as well. They are comprised of 4 non-homologous, interacting proteins, Sir1p, Sir2p, Sir3p, and Sir4p. Sir2p, an NAD-dependent HISTONE DEACETYLASE, is the founding member of the family of SIRTUINS.

Descriptor ID	D038281
MeSH Number(s)	D12.776.354.750.750 D12.776.660.820
Concept/Terms	Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, Saccharomyces cerevisiae Silent Information Regulator Proteins, S cerevisiae SIR Proteins, S cerevisiae Silent Mating Type Information Regulator Protein, S cerevisiae Silent Mating Type Information Regulator Protein, S cerevisiae

Below are MeSH descriptors whose meaning is more general than "Silent Information Regulator Proteins, Saccharomyces cerevisiae".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Fungal Proteins [D12.776.354]
Saccharomyces cerevisiae Proteins [D12.776.354.750]
Silent Information Regulator Proteins, Saccharomyces cerevisiae [D12.776.354.750.750]
Nuclear Proteins [D12.776.660]
Silent Information Regulator Proteins, Saccharomyces cerevisiae [D12.776.660.820]

Below are MeSH descriptors whose meaning is related to "Silent Information Regulator Proteins, Saccharomyces cerevisiae".

Below are MeSH descriptors whose meaning is more specific than "Silent Information Regulator Proteins, Saccharomyces cerevisiae".

publications

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This graph shows the total number of publications written about "Silent Information Regulator Proteins, Saccharomyces cerevisiae" by people in this website by year, and whether "Silent Information Regulator Proteins, Saccharomyces cerevisiae" was a major or minor topic of these publications.

Bar chart showing 11 publications over 9 distinct years, with a maximum of 2 publications in 2009 and 2014

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Year	Major Topic	Minor Topic	Total
2001	1	0	1
2003	1	0	1
2006	0	1	1
2009	1	1	2
2011	1	0	1
2013	0	1	1
2014	2	0	2
2017	0	1	1
2018	1	0	1

Below are the most recent publications written about "Silent Information Regulator Proteins, Saccharomyces cerevisiae" by people in Profiles.

Swygert SG, Senapati S, Bolukbasi MF, Wolfe SA, Lindsay S, Peterson CL. SIR proteins create compact heterochromatin fibers. Proc Natl Acad Sci U S A. 2018 12 04; 115(49):12447-12452.

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Xue Y, Pradhan SK, Sun F, Chronis C, Tran N, Su T, Van C, Vashisht A, Wohlschlegel J, Peterson CL, Timmers HTM, Kurdistani SK, Carey MF. Mot1, Ino80C, and NC2 Function Coordinately to Regulate Pervasive Transcription in Yeast and Mammals. Mol Cell. 2017 Aug 17; 67(4):594-607.e4.

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Manning BJ, Peterson CL. Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17827-32.

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Swygert SG, Manning BJ, Senapati S, Kaur P, Lindsay S, Demeler B, Peterson CL. Solution-state conformation and stoichiometry of yeast Sir3 heterochromatin fibres. Nat Commun. 2014 Aug 28; 5:4751.

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Niepel M, Molloy KR, Williams R, Farr JC, Meinema AC, Vecchietti N, Cristea IM, Chait BT, Rout MP, Strambio-De-Castillia C. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Mol Biol Cell. 2013 Dec; 24(24):3920-38.

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Radman-Livaja M, Ruben G, Weiner A, Friedman N, Kamakaka R, Rando OJ. Dynamics of Sir3 spreading in budding yeast: secondary recruitment sites and euchromatic localization. EMBO J. 2011 Mar 16; 30(6):1012-26.

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Sinha M, Watanabe S, Johnson A, Moazed D, Peterson CL. Recombinational repair within heterochromatin requires ATP-dependent chromatin remodeling. Cell. 2009 Sep 18; 138(6):1109-21.

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Miele A, Bystricky K, Dekker J. Yeast silent mating type loci form heterochromatic clusters through silencer protein-dependent long-range interactions. PLoS Genet. 2009 May; 5(5):e1000478.

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Antczak AJ, Tsubota T, Kaufman PD, Berger JM. Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct Biol. 2006 Dec 13; 6:26.

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Sharp JA, Krawitz DC, Gardner KA, Fox CA, Kaufman PD. The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Genes Dev. 2003 Oct 01; 17(19):2356-61.

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