"Antithrombins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Endogenous factors and drugs that directly inhibit the action of THROMBIN, usually by blocking its enzymatic activity. They are distinguished from INDIRECT THROMBIN INHIBITORS, such as HEPARIN, which act by enhancing the inhibitory effects of antithrombins.
| Descriptor ID |
D000991
|
| MeSH Number(s) |
D27.505.519.389.745.800.449 D27.505.954.502.119.500
|
| Concept/Terms |
Antithrombins- Antithrombins
- Direct Thrombin Inhibitors
- Thrombin Inhibitors, Direct
- Direct Antithrombins
- Antithrombins, Direct
|
Below are MeSH descriptors whose meaning is more general than "Antithrombins".
Below are MeSH descriptors whose meaning is more specific than "Antithrombins".
This graph shows the total number of publications written about "Antithrombins" by people in this website by year, and whether "Antithrombins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Antithrombins" by people in Profiles.
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Tilvawala R, Nemmara VV, Reyes AC, Sorvillo N, Salinger AJ, Cherpokova D, Fukui S, Gutch S, Wagner D, Thompson PR. The role of SERPIN citrullination in thrombosis. Cell Chem Biol. 2021 12 16; 28(12):1728-1739.e5.
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Niu C, Zhao Y, Bobst CE, Savinov SN, Kaltashov IA. Identification of Protein Recognition Elements within Heparin Chains Using Enzymatic Foot-Printing in Solution and Online SEC/MS. Anal Chem. 2020 06 02; 92(11):7565-7573.
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Minsky BB, Abzalimov RR, Niu C, Zhao Y, Kirsch Z, Dubin PL, Savinov SN, Kaltashov IA. Mass Spectrometry Reveals a Multifaceted Role of Glycosaminoglycan Chains in Factor Xa Inactivation by Antithrombin. Biochemistry. 2018 08 14; 57(32):4880-4890.
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Wang G, Bondarenko PV, Kaltashov IA. Multi-step conformational transitions in heat-treated protein therapeutics can be monitored in real time with temperature-controlled electrospray ionization mass spectrometry. Analyst. 2018 Feb 07; 143(3):670-677.
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Tang W, Chang HY, Zhou M, Singh S. Risk of Gastrointestinal Bleeding Among Dabigatran Users - A Self Controlled Case Series Analysis. Sci Rep. 2017 01 20; 7:40120.
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Yogaratnam D, Ditch K, Medeiros K, Doyno C, Fong JJ. Idarucizumab for Reversal of Dabigatran-Associated Anticoagulation. Ann Pharmacother. 2016 10; 50(10):847-54.
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Schulman S, Carrier M, Lee AY, Shivakumar S, Blostein M, Spencer FA, Solymoss S, Barty R, Wang G, Heddle N, Douketis JD. Perioperative Management of Dabigatran: A Prospective Cohort Study. Circulation. 2015 Jul 21; 132(3):167-73.
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Sylvia LM, Ordway L, Pham DT, DeNofrio D, Kiernan M. Bivalirudin for treatment of LVAD thrombosis: a case series. ASAIO J. 2014 Nov-Dec; 60(6):744-7.
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Ross B, Miller MA, Ditch K, Tran M. Clinical experience of life-threatening dabigatran-related bleeding at a large, tertiary care, academic medical center: a case series. J Med Toxicol. 2014 Jun; 10(2):223-8.
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Blum J, Carreiro S, Hack JB. Intravenous lipid emulsion does not reverse dabigatran-induced anticoagulation in a rat model. Acad Emerg Med. 2013 Oct; 20(10):1022-5.