Insulin-Like Growth Factor I

"Insulin-Like Growth Factor I" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.

Descriptor ID	D007334
MeSH Number(s)	D12.644.276.937.400 D12.776.124.862.400 D12.776.467.937.400 D23.529.937.400
Concept/Terms	Insulin-Like Growth Factor I Insulin-Like Growth Factor I Insulin-Like Somatomedin Peptide I Insulin Like Somatomedin Peptide I Somatomedin C IGF-I-SmC IGF-1 IGF-I Insulin Like Growth Factor I

Below are MeSH descriptors whose meaning is more general than "Insulin-Like Growth Factor I".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Somatomedins [D12.644.276.937]
Insulin-Like Growth Factor I [D12.644.276.937.400]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Somatomedins [D12.776.124.862]
Insulin-Like Growth Factor I [D12.776.124.862.400]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Somatomedins [D12.776.467.937]
Insulin-Like Growth Factor I [D12.776.467.937.400]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Somatomedins [D23.529.937]
Insulin-Like Growth Factor I [D23.529.937.400]

Below are MeSH descriptors whose meaning is related to "Insulin-Like Growth Factor I".

Below are MeSH descriptors whose meaning is more specific than "Insulin-Like Growth Factor I".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Insulin-Like Growth Factor I" by people in this website by year, and whether "Insulin-Like Growth Factor I" was a major or minor topic of these publications.

Bar chart showing 62 publications over 25 distinct years, with a maximum of 5 publications in 2006 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	0	1
1998	2	0	2
1999	1	0	1
2000	2	0	2
2001	2	0	2
2003	2	0	2
2004	2	2	4
2005	1	1	2
2006	2	3	5
2007	0	1	1
2008	1	2	3
2009	2	1	3
2010	2	2	4
2011	4	1	5
2012	3	1	4
2013	2	0	2
2014	2	1	3
2015	1	2	3
2016	3	0	3
2017	2	1	3
2018	1	1	2
2019	0	2	2
2020	0	1	1
2021	1	0	1
2022	0	1	1

Below are the most recent publications written about "Insulin-Like Growth Factor I" by people in Profiles.

Barry CV, Chrysanthopoulou SA, Tallo V, Jarilla B, Vargas Z, McDonald E, Gundogan F, Friedman JF. The Impact of Prenatal Alcohol Exposure on Longitudinal Growth, Nutritional Status, and Insulin-Like Growth Factor 1 in Early Childhood in Leyte, the Philippines. J Pediatr. 2024 Jun; 269:113977.

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Chen C, Liao J, Xia Y, Liu X, Jones R, Haran J, McCormick B, Sampson TR, Alam A, Ye K. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation. Gut. 2022 11; 71(11):2233-2252.

View in: PubMed
Lero MW, Shaw LM. Diversity of insulin and IGF signaling in breast cancer: Implications for therapy. Mol Cell Endocrinol. 2021 05 01; 527:111213.

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Chrudinov? M, Moreau F, Noh HL, P?n?kov? T, ??kov? L, Friedline RH, Valenzuela FA, Kim JK, Jir?cek J, Kahn CR, Altindis E. Characterization of viral insulins reveals white adipose tissue-specific effects in mice. Mol Metab. 2021 02; 44:101121.

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Inzaghi E, Reiter E, Cianfarani S. The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy. Horm Res Paediatr. 2019; 92(2):71-83.

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De Rosa MJ, Veuthey T, Florman J, Grant J, Blanco MG, Andersen N, Donnelly J, Rayes D, Alkema MJ. The flight response impairs cytoprotective mechanisms by activating the insulin pathway. Nature. 2019 09; 573(7772):135-138.

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Crew KD, Anderson GL, Hershman DL, Terry MB, Tehranifar P, Lew DL, Yee M, Brown EA, Kairouz SS, Kuwajerwala N, Bevers T, Doster JE, Zarwan C, Kruper L, Minasian LM, Ford L, Arun B, Neuhouser M, Goodman GE, Brown PH. Randomized Double-Blind Placebo-Controlled Biomarker Modulation Study of Vitamin D Supplementation in Premenopausal Women at High Risk for Breast Cancer (SWOG S0812). Cancer Prev Res (Phila). 2019 07; 12(7):481-490.

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Switkowski KM, Jacques PF, Must A, Fleisch A, Oken E. Associations of protein intake in early childhood with body composition, height, and insulin-like growth factor I in mid-childhood and early adolescence. Am J Clin Nutr. 2019 04 01; 109(4):1154-1163.

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Anastasilakis AD, Koulaxis D, Upadhyay J, Pagkalidou E, Kefala N, Perakakis N, Polyzos SA, Economou F, Mantzoros CS. Free IGF-1, Intact IGFBP-4, and PicoPAPP-A are Altered in Acute Myocardial Infarction Compared to Stable Coronary Artery Disease and Healthy Controls. Horm Metab Res. 2019 Feb; 51(2):112-119.

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DeVore SB, Young CH, Li G, Sundararajan A, Ramaraj T, Mudge J, Schilkey F, Muth A, Thompson PR, Cherrington BD. Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells. Mol Cell Biol. 2018 10 01; 38(19).

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