Microphthalmia-Associated Transcription Factor

"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.

Descriptor ID	D051739
MeSH Number(s)	D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
Concept/Terms	Microphthalmia-Associated Transcription Factor Microphthalmia-Associated Transcription Factor Microphthalmia Associated Transcription Factor Transcription Factor, Microphthalmia-Associated MITF Transcription Factor Transcription Factor Microphthalmia Microphthalmia, Transcription Factor MITF Protein

Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.103.500]
Microphthalmia-Associated Transcription Factor [D12.776.260.103.500.500]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.260.108.092]
Microphthalmia-Associated Transcription Factor [D12.776.260.108.092.500]
Transcription Factors [D12.776.930]
Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.125.500]
Microphthalmia-Associated Transcription Factor [D12.776.930.125.500.500]
Basic-Leucine Zipper Transcription Factors [D12.776.930.127]
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776.930.127.092]
Microphthalmia-Associated Transcription Factor [D12.776.930.127.092.500]

Below are MeSH descriptors whose meaning is related to "Microphthalmia-Associated Transcription Factor".

Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.

Bar chart showing 12 publications over 8 distinct years, with a maximum of 3 publications in 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2007	1	0	1
2009	0	1	1
2014	2	0	2
2015	2	1	3
2016	1	1	2
2017	0	1	1
2019	1	0	1

Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.

Gramann AK, Venkatesan AM, Guerin M, Ceol CJ. Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling. Elife. 2019 12 23; 8.

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Venkatesan AM, Vyas R, Gramann AK, Dresser K, Gujja S, Bhatnagar S, Chhangawala S, Gomes CBF, Xi HS, Lian CG, Houvras Y, Edwards YJK, Deng A, Green M, Ceol CJ. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. J Clin Invest. 2018 01 02; 128(1):294-308.

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Zand S, Buzney E, Duncan LM, Dadras SS. Heterogeneity of Metastatic Melanoma: ?Correlation of MITF With Its Transcriptional Targets MLSN1, PEDF, HMB-45, and MART-1. Am J Clin Pathol. 2016 Sep; 146(3):353-60.

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Wojciechowska S, Zeng Z, Lister JA, Ceol CJ, Patton EE. Melanoma Regression and Recurrence in Zebrafish. Methods Mol Biol. 2016; 1451:143-53.

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Dadras SS, Lin RJ, Fisher DE. Authors' Reply. Am J Pathol. 2015 Jul; 185(7):2070.

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Iyengar S, Kasheta M, Ceol CJ. Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells. Dev Cell. 2015 Jun 22; 33(6):631-43.

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Perrino CM, Wang JF, Collins BT. Microphthalmia transcription factor immunohistochemistry for FNA biopsy of ocular malignant melanoma. Cancer Cytopathol. 2015 Jul; 123(7):394-400.

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Dadras SS, Lin RJ, Razavi G, Kawakami A, Du J, Feige E, Milner DA, Loda MF, Granter SR, Detmar M, Widlund HR, Horstmann MA, Fisher DE. A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression. Am J Pathol. 2015 Jan; 185(1):252-65.

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Baranowska K?rberg I, Sundstr?m E, Meadows JR, Rosengren Pielberg G, Gustafson U, Hedhammar ?, Karlsson EK, Seddon J, S?derberg A, Vil? C, Zhang X, ?kesson M, Lindblad-Toh K, Andersson G, Andersson L. A simple repeat polymorphism in the MITF-M promoter is a key regulator of white spotting in dogs. PLoS One. 2014; 9(8):e104363.

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Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. Circ Res. 2009 Feb 27; 104(4):455-65.

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