"Methacholine Chloride" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1116)
Descriptor ID |
D016210
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MeSH Number(s) |
D02.092.877.883.555.500 D02.675.276.534.500
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Concept/Terms |
Methacholine Chloride- Methacholine Chloride
- Chloride, Methacholine
- Acetyl-beta-methacholine Chloride
- Acetyl beta methacholine Chloride
- Mecholine
- 2-(Acetyloxy)-N,N,N-trimethyl-1-propanaminium Chloride
- Acetyl-2-methylcholine Chloride
- Acetyl 2 methylcholine Chloride
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Below are MeSH descriptors whose meaning is more general than "Methacholine Chloride".
Below are MeSH descriptors whose meaning is more specific than "Methacholine Chloride".
This graph shows the total number of publications written about "Methacholine Chloride" by people in this website by year, and whether "Methacholine Chloride" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
1999 | 0 | 1 | 1 |
2000 | 1 | 2 | 3 |
2001 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2008 | 1 | 0 | 1 |
2009 | 0 | 1 | 1 |
2013 | 0 | 1 | 1 |
2016 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Methacholine Chloride" by people in Profiles.
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Lu P, ElMallah MK, Liu Z, Wu C, Chen J, Lifshitz LM, ZhuGe R. Genetic deletion of the Tas2r143/Tas2r135/Tas2r126 cluster reveals that TAS2Rs may not mediate bitter tastant-induced bronchodilation. J Cell Physiol. 2021 09; 236(9):6407-6423.
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Keeler AM, Liu D, Zieger M, Xiong L, Salemi J, Bellv? K, Byrne BJ, Fuller DD, ZhuGe R, ElMallah MK. Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. Am J Physiol Lung Cell Mol Physiol. 2017 06 01; 312(6):L873-L881.
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Aldrich TK, Weakley J, Dhar S, Hall CB, Crosse T, Banauch GI, Weiden MD, Izbicki G, Cohen HW, Gupta A, King C, Christodoulou V, Webber MP, Zeig-Owens R, Moir W, Nolan A, Kelly KJ, Prezant DJ. Bronchial Reactivity and Lung Function After World Trade Center Exposure. Chest. 2016 Dec; 150(6):1333-1340.
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Gartman EJ, Dinino EK, Koo P, Roberts MB, McCool FD. Methacholine-induced airway hyper-reactivity phenotypes. J Asthma. 2013 Aug; 50(6):629-33.
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Ma B, Sanderson M, Bates JH. Airway-parenchymal interdependence in the lung slice. Respir Physiol Neurobiol. 2013 Jan 15; 185(2):211-6.
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Bai Y, Edelmann M, Sanderson MJ. The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca(2+) signaling of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L347-61.
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Harris RS, Winkler T, Musch G, Vidal Melo MF, Schroeder T, Tgavalekos N, Venegas JG. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol (1985). 2009 Jul; 107(1):266-74.
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Bai Y, Sanderson MJ. The contribution of Ca2+ signaling and Ca2+ sensitivity to the regulation of airway smooth muscle contraction is different in rats and mice. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L947-58.
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Brown RH, Kaczka DW, Fallano K, Chen S, Mitzner W. Temporal variability in the responses of individual canine airways to methacholine. J Appl Physiol (1985). 2008 May; 104(5):1381-6.
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Bai Y, Zhang M, Sanderson MJ. Contractility and Ca2+ signaling of smooth muscle cells in different generations of mouse airways. Am J Respir Cell Mol Biol. 2007 Jan; 36(1):122-30.