Calcium Signaling

"Calcium Signaling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

Descriptor ID	D020013
MeSH Number(s)	G02.111.820.800.100 G03.143.500.100 G04.835.800.100
Concept/Terms	Calcium Signaling Calcium Signaling Calcium Signalings Signaling, Calcium Signalings, Calcium Calcium Waves Calcium Waves Calcium Wave Wave, Calcium Waves, Calcium Calcium Oscillations Calcium Oscillation Oscillation, Calcium Oscillations, Calcium Calcium Spikes Calcium Spikes Calcium Spike Spike, Calcium Spikes, Calcium Calcium Puffs Calcium Puffs Calcium Puff Puff, Calcium Puffs, Calcium Calcium Sparks Calcium Sparks Calcium Spark Spark, Calcium Sparks, Calcium

Below are MeSH descriptors whose meaning is more general than "Calcium Signaling".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Second Messenger Systems [G02.111.820.800]
Calcium Signaling [G02.111.820.800.100]
Metabolism [G03]
Biological Transport [G03.143]
Ion Transport [G03.143.500]
Calcium Signaling [G03.143.500.100]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Second Messenger Systems [G04.835.800]
Calcium Signaling [G04.835.800.100]

Below are MeSH descriptors whose meaning is related to "Calcium Signaling".

Below are MeSH descriptors whose meaning is more specific than "Calcium Signaling".

Calcium Signaling
Excitation Contraction Coupling

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcium Signaling" by people in this website by year, and whether "Calcium Signaling" was a major or minor topic of these publications.

Bar chart showing 138 publications over 28 distinct years, with a maximum of 10 publications in 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	2	0	2
2000	3	0	3
2001	1	1	2
2002	1	3	4
2003	7	1	8
2004	4	4	8
2005	4	0	4
2006	6	1	7
2007	5	4	9
2008	6	2	8
2009	1	2	3
2010	2	1	3
2011	4	2	6
2012	4	3	7
2013	5	5	10
2014	2	5	7
2015	5	4	9
2016	0	2	2
2017	0	2	2
2018	6	3	9
2019	3	4	7
2020	1	1	2
2021	3	1	4
2023	0	1	1
2024	0	2	2
2025	3	3	6
2026	1	1	2

Below are the most recent publications written about "Calcium Signaling" by people in Profiles.

Vergara S, Duarte-Zúñiga J, Hidalgo C, Suárez-Suárez C, Castillo K, Piesche M, Aguilera F, Fissore RA, Hinostroza F, Veraguas-Dávila D, Carvacho I. Expression and functional characterization of the TRPV3 channel in domestic cat (Felis catus) mature oocytes. Biol Res. 2026 Jul 06; 59(1).

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Suthar KP, Hounsell C, Fan Y, Bergmann A. Calcium signaling regulates apoptosis-induced proliferation in Drosophila. PLoS Biol. 2026 Jan; 24(1):e3003607.

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Tolomeo M, Magliocca V, Petrini S, Nisco A, Barbaro R, Lanza M, Piccione M, Giudetti AM, Massey K, Console L, Indiveri C, Zanier K, Bertini E, Persichini T, Compagnucci C, Colella M, Barile M. Altered dimerization of certain riboflavin transporter 2 mutants: a possible source of UPR, altered calcium signalling and mitochondrial derangements in RTD2. Arch Biochem Biophys. 2026 01; 775:110675.

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Stadinski BD, Mills EA, Humphries PA, Cleveland SB, Dow P, Murakami K, Li YR, Murakami M, Ono M, Au-Yeung BB, Morris GP, Zúñiga-Pflücker JC, Campbell RA, Griffiths ER, Huseby ES, Lo WL. Age-dependent Zap70 expression in thymocytes regulates selection of the neonatal regulatory T cell repertoire. Nat Immunol. 2025 Dec; 26(12):2256-2269.

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Fissore RA, Lopes EM, Carpentiero F. Zebrafish sperm outsource activation to eggs' protease-activated receptors. PLoS Biol. 2025 06; 23(6):e3003214.

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Luque GM, Jabloñski M, Schiavi-Ehrenhaus LJ, Del Prado RC, Balbach M, Romarowski A, Martin-Hidalgo D, Visconti PE, Krapf D, Darszon A, Krapf D, Buck J, Levin LR, Buffone MG. Bovine serum albumin-induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation. J Physiol. 2025 05; 603(9):2633-2653.

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Lee HC, Akizawa H, Fissore RA. Roles of the EF-hand domain of PLCZ1 in establishing species-specific Ca2+ oscillations in mouse and rat fertilization†. Biol Reprod. 2025 04 13; 112(4):663-674.

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Sánchez-Cárdenas C, Oliver EI, Chávez JC, Luque GM, Hernández-Cruz A, Buffone MG, Darszon A, Visconti PE, Romarowski A. Ion channels and transporters involved in calcium flux regulation in mammalian sperm. Curr Top Dev Biol. 2025; 162:351-385.

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Zhang X, Zhang X, Cheng S, Fan X, Bao H, Zhou S, Ping J. Spatiotemporal Cell Control via High-Precision Electronic Regulation of Microenvironmental pH. Nano Lett. 2024 12 11; 24(49):15645-15651.

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Debold EP, Westerblad H. New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: the Marion J. Siegman Award Lectureships. Am J Physiol Cell Physiol. 2024 10 01; 327(4):C946-C958.

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