Calcium Signaling

"Calcium Signaling" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.

Descriptor ID	D020013
MeSH Number(s)	G02.111.820.800.100 G03.143.500.100 G04.835.800.100
Concept/Terms	Calcium Signaling Calcium Signaling Calcium Signalings Signaling, Calcium Signalings, Calcium Calcium Waves Calcium Waves Calcium Wave Wave, Calcium Waves, Calcium Calcium Oscillations Calcium Oscillation Oscillation, Calcium Oscillations, Calcium Calcium Spikes Calcium Spikes Calcium Spike Spike, Calcium Spikes, Calcium Calcium Puffs Calcium Puffs Calcium Puff Puff, Calcium Puffs, Calcium Calcium Sparks Calcium Sparks Calcium Spark Spark, Calcium Sparks, Calcium

Below are MeSH descriptors whose meaning is more general than "Calcium Signaling".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Signal Transduction [G02.111.820]
Second Messenger Systems [G02.111.820.800]
Calcium Signaling [G02.111.820.800.100]
Metabolism [G03]
Biological Transport [G03.143]
Ion Transport [G03.143.500]
Calcium Signaling [G03.143.500.100]
Cell Physiological Phenomena [G04]
Signal Transduction [G04.835]
Second Messenger Systems [G04.835.800]
Calcium Signaling [G04.835.800.100]

Below are MeSH descriptors whose meaning is related to "Calcium Signaling".

Below are MeSH descriptors whose meaning is more specific than "Calcium Signaling".

Calcium Signaling
Excitation Contraction Coupling

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Calcium Signaling" by people in this website by year, and whether "Calcium Signaling" was a major or minor topic of these publications.

Bar chart showing 128 publications over 27 distinct years, with a maximum of 9 publications in 2003 and 2007 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
1999	2	0	2
2000	3	0	3
2001	1	1	2
2002	1	3	4
2003	7	2	9
2004	4	4	8
2005	4	0	4
2006	6	1	7
2007	5	4	9
2008	6	2	8
2009	0	2	2
2010	2	1	3
2011	4	2	6
2012	4	3	7
2013	4	3	7
2014	1	5	6
2015	4	4	8
2016	0	2	2
2017	0	2	2
2018	6	3	9
2019	3	3	6
2020	0	2	2
2021	3	1	4
2023	0	1	1
2024	0	2	2
2025	2	2	4

Below are the most recent publications written about "Calcium Signaling" by people in Profiles.

Fissore RA, Lopes EM, Carpentiero F. Zebrafish sperm outsource activation to eggs' protease-activated receptors. PLoS Biol. 2025 Jun; 23(6):e3003214.

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Luque GM, Jablo?ski M, Schiavi-Ehrenhaus LJ, Del Prado RC, Balbach M, Romarowski A, Martin-Hidalgo D, Visconti PE, Krapf D, Darszon A, Krapf D, Buck J, Levin LR, Buffone MG. Bovine serum albumin-induced calcium influx triggers soluble adenylyl cyclase activation and cyclic AMP signalling pathways in mouse sperm capacitation. J Physiol. 2025 May; 603(9):2633-2653.

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Lee HC, Akizawa H, Fissore RA. Roles of the EF-hand domain of PLCZ1 in establishing species-specific Ca2+ oscillations in mouse and rat fertilization?. Biol Reprod. 2025 Apr 13; 112(4):663-674.

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S?nchez-C?rdenas C, Oliver EI, Ch?vez JC, Luque GM, Hern?ndez-Cruz A, Buffone MG, Darszon A, Visconti PE, Romarowski A. Ion channels and transporters involved in calcium flux regulation in mammalian sperm. Curr Top Dev Biol. 2025; 162:351-385.

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Zhang X, Zhang X, Cheng S, Fan X, Bao H, Zhou S, Ping J. Spatiotemporal Cell Control via High-Precision Electronic Regulation of Microenvironmental pH. Nano Lett. 2024 12 11; 24(49):15645-15651.

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Debold EP, Westerblad H. New insights into the cellular and molecular mechanisms of skeletal muscle fatigue: the Marion J. Siegman Award Lectureships. Am J Physiol Cell Physiol. 2024 Oct 01; 327(4):C946-C958.

View in: PubMed
Akizawa H, Lopes EM, Fissore RA. Zn2+ is essential for Ca2+ oscillations in mouse eggs. Elife. 2023 Dec 15; 12.

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Luque GM, Xu X, Romarowski A, Gervasi MG, Orta G, De la Vega-Beltr?n JL, Stival C, Gilio N, Dalotto-Moreno T, Krapf D, Visconti PE, Krapf D, Darszon A, Buffone MG. Cdc42 localized in the CatSper signaling complex regulates cAMP-dependent pathways in mouse sperm. FASEB J. 2021 08; 35(8):e21723.

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Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim IK, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ. Calcium signaling induces a partial EMT. EMBO Rep. 2021 09 06; 22(9):e51872.

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Balestrini PA, Sanchez-Cardenas C, Luque GM, Baro Graf C, Sierra JM, Hern?ndez-Cruz A, Visconti PE, Krapf D, Darszon A, Buffone MG. Membrane hyperpolarization abolishes calcium oscillations that prevent induced acrosomal exocytosis in human sperm. FASEB J. 2021 06; 35(6):e21478.

View in: PubMed

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