An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

Descriptor ID	D017242
MeSH Number(s)	D12.776.124.486.274.920.325.200 D12.776.124.790.223.200 D12.776.377.715.182.200
Concept/Terms	Complement Factor H Complement Factor H Factor H, Complement Factor H

Below are MeSH descriptors whose meaning is more general than "Complement Factor H".

Below are MeSH descriptors whose meaning is related to "Complement Factor H".

Below are MeSH descriptors whose meaning is more specific than "Complement Factor H".