Osteocalcin

"Osteocalcin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.

Descriptor ID	D015675
MeSH Number(s)	D12.776.157.125.700
Concept/Terms	Osteocalcin Osteocalcin Bone gamma-Carboxyglutamic Acid Protein Bone gamma Carboxyglutamic Acid Protein Vitamin K-Dependent Bone Protein Vitamin K Dependent Bone Protein Calcium-Binding Protein, Vitamin K-Dependent Calcium Binding Protein, Vitamin K Dependent Gla Protein, Bone 4-Carboxyglutamic Protein, Bone 4 Carboxyglutamic Protein, Bone Bone 4-Carboxyglutamic Protein Protein, Bone 4-Carboxyglutamic Bone Gla Protein Protein, Bone Gla

Below are MeSH descriptors whose meaning is more general than "Osteocalcin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Calcium-Binding Proteins [D12.776.157.125]
Osteocalcin [D12.776.157.125.700]

Below are MeSH descriptors whose meaning is related to "Osteocalcin".

Below are MeSH descriptors whose meaning is more specific than "Osteocalcin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Osteocalcin" by people in this website by year, and whether "Osteocalcin" was a major or minor topic of these publications.

Bar chart showing 43 publications over 17 distinct years, with a maximum of 7 publications in 2002 and 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1999	0	1	1
2000	0	1	1
2001	1	2	3
2002	4	3	7
2003	2	2	4
2004	4	3	7
2006	1	1	2
2007	2	2	4
2008	2	0	2
2009	2	2	4
2010	0	1	1
2011	0	1	1
2012	2	0	2
2014	0	1	1
2017	0	1	1
2018	0	1	1
2020	0	1	1

Below are the most recent publications written about "Osteocalcin" by people in Profiles.

Wu X, Zhang T, Hoff B, Suvarnapathaki S, Lantigua D, McCarthy C, Wu B, Camci-Unal G. Mineralized Hydrogels Induce Bone Regeneration in Critical Size Cranial Defects. Adv Healthc Mater. 2021 02; 10(4):e2001101.

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Toor RH, Tasadduq R, Adhikari A, Chaudhary MI, Lian JB, Stein JL, Stein GS, Shakoori AR. Ethyl acetate and n-butanol fraction of Cissus quadrangularis promotes the mineralization potential of murine pre-osteoblast cell line MC3T3-E1 (sub-clone 4). J Cell Physiol. 2019 07; 234(7):10300-10314.

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Filion TM, Skelly JD, Huang H, Greiner DL, Ayers DC, Song J. Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue. Stem Cell Res Ther. 2017 03 11; 8(1):65.

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Varela N, Aranguiz A, Lizama C, Sepulveda H, Antonelli M, Thaler R, Moreno RD, Montecino M, Stein GS, van Wijnen AJ, Galindo M. Mitotic Inheritance of mRNA Facilitates Translational Activation of the Osteogenic-Lineage Commitment Factor Runx2 in Progeny of Osteoblastic Cells. J Cell Physiol. 2016 May; 231(5):1001-14.

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Aguilar R, Grandy R, Meza D, Sepulveda H, Pihan P, van Wijnen AJ, Lian JB, Stein GS, Stein JL, Montecino M. A functional N-terminal domain in C/EBP?-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol. 2014 Oct; 229(10):1521-8.

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Yu S, Sharma R, Nie D, Jiao H, Im HJ, Lai Y, Zhao Z, Zhu K, Fan J, Chen D, Wang Q, Xiao G. ADAR1 ablation decreases bone mass by impairing osteoblast function in mice. Gene. 2013 Jan 15; 513(1):101-10.

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Haley S, Beachy J, Ivaska KK, Slater H, Smith S, Moyer-Mileur LJ. Tactile/kinesthetic stimulation (TKS) increases tibial speed of sound and urinary osteocalcin (U-MidOC and unOC) in premature infants (29-32weeks PMA). Bone. 2012 Oct; 51(4):661-6.

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Soung do Y, Talebian L, Matheny CJ, Guzzo R, Speck ME, Lieberman JR, Speck NA, Drissi H. Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. J Bone Miner Res. 2012 Jul; 27(7):1585-97.

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Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. Ski inhibits TGF-?/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. J Cell Biochem. 2012 Jun; 113(6):2156-66.

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Gundberg CM, Lian JB, Booth SL. Vitamin K-dependent carboxylation of osteocalcin: friend or foe? Adv Nutr. 2012 Mar 01; 3(2):149-57.

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