Acute-Phase Proteins

"Acute-Phase Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.

Descriptor ID	D000209
MeSH Number(s)	D12.776.124.050
Concept/Terms	Acute-Phase Proteins Acute-Phase Proteins Acute Phase Proteins Proteins, Acute-Phase Proteins, Acute Phase Reactants, Acute-Phase Reactants, Acute Phase Acute-Phase Reactants Acute Phase Reactants Acute-Phase Protein Acute Phase Protein Protein, Acute-Phase Acute-Phase Glycoproteins Acute-Phase Glycoproteins Acute Phase Glycoproteins Glycoproteins, Acute-Phase

Below are MeSH descriptors whose meaning is more general than "Acute-Phase Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Blood Proteins [D12.776.124]
Acute-Phase Proteins [D12.776.124.050]

Below are MeSH descriptors whose meaning is related to "Acute-Phase Proteins".

Below are MeSH descriptors whose meaning is more specific than "Acute-Phase Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Acute-Phase Proteins" by people in this website by year, and whether "Acute-Phase Proteins" was a major or minor topic of these publications.

Bar chart showing 29 publications over 20 distinct years, with a maximum of 4 publications in 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	1	0	1
1998	3	1	4
1999	1	0	1
2000	1	0	1
2001	0	1	1
2002	2	0	2
2003	1	0	1
2004	2	0	2
2005	1	0	1
2006	1	0	1
2009	1	0	1
2010	0	1	1
2012	2	1	3
2013	1	0	1
2014	0	3	3
2015	0	1	1
2019	1	0	1
2020	1	0	1
2021	1	0	1
2026	0	1	1

Below are the most recent publications written about "Acute-Phase Proteins" by people in Profiles.

Rojas-Pirela M, Herrera-Flores C, Costa-Alba P, Salete-Granado D, Aguilar ML, Puertas-Miranda D, Cicu?ndez B, P?rez-Nieto M?, P?rez-Albornoz C, Folgueira C, Mora A, Sabio G, Marcos M. Analysis of Antimicrobial Peptide Expression Under Acute and Chronic Alcohol Exposure: A Cross-Sectional Study and a Systematic Review of the Literature. Int J Mol Sci. 2026 Feb 20; 27(4).

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Kumar NP, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Sivakumar S, Hissar S, Kornfeld H, Babu S. Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure. Front Immunol. 2021; 12:731878.

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Bennike TB, Fatou B, Angelidou A, Diray-Arce J, Falsafi R, Ford R, Gill EE, van Haren SD, Idoko OT, Lee AH, Ben-Othman R, Pomat WS, Shannon CP, Smolen KK, Tebbutt SJ, Ozonoff A, Richmond PC, van den Biggelaar AHJ, Hancock REW, Kampmann B, Kollmann TR, Levy O, Steen H. Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life. Front Immunol. 2020; 11:578505.

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Saha B, Tornai D, Kodys K, Adejumo A, Lowe P, McClain C, Mitchell M, McCullough A, Dasarathy S, Kroll-Desrosiers A, Barton B, Radaeva S, Szabo G. Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis. Hepatology. 2019 10; 70(4):1134-1149.

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Hilliard KL, Allen E, Traber KE, Yamamoto K, Stauffer NM, Wasserman GA, Jones MR, Mizgerd JP, Quinton LJ. The Lung-Liver Axis: A Requirement for Maximal Innate Immunity and Hepatoprotection during Pneumonia. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):378-90.

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Bala S, Marcos M, Gattu A, Catalano D, Szabo G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One. 2014; 9(5):e96864.

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Serra R, Gallelli L, Conti A, De Caridi G, Massara M, Spinelli F, Buffone G, Cali? FG, Amato B, Ceglia S, Spaziano G, Scaramuzzino L, Ferrarese AG, Grande R, de Franciscis S. The effects of sulodexide on both clinical and molecular parameters in patients with mixed arterial and venous ulcers of lower limbs. Drug Des Devel Ther. 2014; 8:519-27.

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Kay J, Morgacheva O, Messing SP, Kremer JM, Greenberg JD, Reed GW, Gravallese EM, Furst DE. Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year. Arthritis Res Ther. 2014 Feb 03; 16(1):R40.

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Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP. Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card Fail. 2014 Jan; 20(1):31-7.

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Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun. 2013 May; 81(5):1644-53.

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