Protein Tyrosine Phosphatase, Non-Receptor Type 11

"Protein Tyrosine Phosphatase, Non-Receptor Type 11" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subtype of non-receptor protein tyrosine phosphatases that contain two SRC HOMOLOGY DOMAINS. Mutations in the gene for protein tyrosine phosphatase, non-receptor type 11 are associated with NOONAN SYNDROME.

Descriptor ID	D054592
MeSH Number(s)	D08.811.277.352.650.775.300.800 D08.811.277.352.650.775.700.800 D12.644.360.585.800 D12.776.476.564.800 D12.776.476.800.800
Concept/Terms	Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non-Receptor Type 11 Protein Tyrosine Phosphatase, Non Receptor Type 11 SHPTP2 Phosphotyrosine Phosphatase Syp SHP-2 Protein-Tyrosine Phosphatase Protein Tyrosine Phosphatase PTP3 Shp-2 Tyrosine Phosphatase Shp 2 Tyrosine Phosphatase Tyrosine Phosphatase, Shp-2 SHP2 Phosphatase Phosphatase, SHP2 Protein-Tyrosine-Phosphatase 2C Protein Tyrosine Phosphatase 2C

Below are MeSH descriptors whose meaning is more general than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Esterases [D08.811.277.352]
Phosphoric Monoester Hydrolases [D08.811.277.352.650]
Protein Tyrosine Phosphatases [D08.811.277.352.650.775]
Protein Tyrosine Phosphatases, Non-Receptor [D08.811.277.352.650.775.300]
Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.300.800]
SH2 Domain-Containing Protein Tyrosine Phosphatases [D08.811.277.352.650.775.700]
Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D08.811.277.352.650.775.700.800]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Protein Tyrosine Phosphatases, Non-Receptor [D12.644.360.585]
Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.644.360.585.800]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Protein Tyrosine Phosphatases, Non-Receptor [D12.776.476.564]
Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.564.800]
SH2 Domain-Containing Protein Tyrosine Phosphatases [D12.776.476.800]
Protein Tyrosine Phosphatase, Non-Receptor Type 11 [D12.776.476.800.800]

Below are MeSH descriptors whose meaning is related to "Protein Tyrosine Phosphatase, Non-Receptor Type 11".

Below are MeSH descriptors whose meaning is more specific than "Protein Tyrosine Phosphatase, Non-Receptor Type 11".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in this website by year, and whether "Protein Tyrosine Phosphatase, Non-Receptor Type 11" was a major or minor topic of these publications.

Bar chart showing 16 publications over 11 distinct years, with a maximum of 5 publications in 1997

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	1	1
1997	0	5	5
1998	0	2	2
1999	0	1	1
2001	0	1	1
2003	0	1	1
2006	0	1	1
2010	1	0	1
2012	1	0	1
2016	0	1	1
2019	0	1	1

Below are the most recent publications written about "Protein Tyrosine Phosphatase, Non-Receptor Type 11" by people in Profiles.

Patel SS, Ho C, Ptashkin RN, Sadigh S, Bagg A, Geyer JT, Xu ML, Prebet T, Mason EF, Seegmiller AC, Morgan EA, Steensma DP, Winer ES, Wong WJ, Hasserjian RP, Weinberg OK. Clinicopathologic and genetic characterization of nonacute NPM1-mutated myeloid neoplasms. Blood Adv. 2019 05 14; 3(9):1540-1545.

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Gu S, Chan WW, Mohi G, Rosenbaum J, Sayad A, Lu Z, Virtanen C, Li S, Neel BG, Van Etten RA. Distinct GAB2 signaling pathways are essential for myeloid and lymphoid transformation and leukemogenesis by BCR-ABL1. Blood. 2016 Apr 07; 127(14):1803-13.

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Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG. Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology. 2012 Jul; 153(7):3158-69.

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Yang X, Dutta U, Shaw LM. SHP2 mediates the localized activation of Fyn downstream of the ?6?4 integrin to promote carcinoma invasion. Mol Cell Biol. 2010 Nov; 30(22):5306-17.

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Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 01; 66(1):331-42.

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Burkart A, Samii B, Corvera S, Shpetner HS. Regulation of the SHP-2 tyrosine phosphatase by a novel cholesterol- and cell confluence-dependent mechanism. J Biol Chem. 2003 May 16; 278(20):18360-7.

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Mishra AK, Zhang A, Niu T, Yang J, Liang X, Zhao ZJ, Zhou GW. Substrate specificity of protein tyrosine phosphatase: differential behavior of SHP-1 and SHP-2 towards signal regulation protein SIRPalpha1. J Cell Biochem. 2002; 84(4):840-6.

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Hsu HC, Shultz LD, Su X, Shi J, Yang PA, Relyea MJ, Zhang HG, Mountz JD. Mutation of the hematopoietic cell phosphatase (Hcph) gene is associated with resistance to gamma-irradiation-induced apoptosis in Src homology protein tyrosine phosphatase (SHP)-1-deficient "motheaten" mutant mice. J Immunol. 2001 Jan 15; 166(2):772-80.

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Umeda S, Beamer WG, Takagi K, Naito M, Hayashi S, Yonemitsu H, Yi T, Shultz LD. Deficiency of SHP-1 protein-tyrosine phosphatase activity results in heightened osteoclast function and decreased bone density. Am J Pathol. 1999 Jul; 155(1):223-33.

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Yang W, Mckenna SD, Jiao H, Tabrizi M, Lynes MA, Shultz LD, Yi T. SHP-1 deficiency in B-lineage cells is associated with heightened lyn protein expression and increased lyn kinase activity. Exp Hematol. 1998 Nov; 26(12):1126-32.

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