Interleukin-5

"Interleukin-5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cytokine that promotes differentiation and activation of EOSINOPHILS. It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells.

Descriptor ID	D015848
MeSH Number(s)	D12.644.276.374.465.202 D12.776.467.374.465.186 D23.529.374.465.202
Concept/Terms	Interleukin-5 Interleukin-5 Interleukin 5 BCGF-II Differentiation Factor, Eosinophil T-Cell-Replacing Factor T Cell Replacing Factor IL-5 IL5 T-Cell Replacing Factor Replacing Factor, T-Cell B-Cell Growth Factor-II B Cell Growth Factor II Eosinophil Differentiation Factor

Below are MeSH descriptors whose meaning is more general than "Interleukin-5".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Interleukins [D12.644.276.374.465]
Interleukin-5 [D12.644.276.374.465.202]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Interleukins [D12.776.467.374.465]
Interleukin-5 [D12.776.467.374.465.186]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Interleukins [D23.529.374.465]
Interleukin-5 [D23.529.374.465.202]

Below are MeSH descriptors whose meaning is related to "Interleukin-5".

Below are MeSH descriptors whose meaning is more specific than "Interleukin-5".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Interleukin-5" by people in this website by year, and whether "Interleukin-5" was a major or minor topic of these publications.

Bar chart showing 24 publications over 16 distinct years, with a maximum of 3 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1999	1	1	2
2000	2	0	2
2001	0	1	1
2002	0	1	1
2003	0	3	3
2004	0	1	1
2005	0	2	2
2006	0	2	2
2007	0	2	2
2009	1	1	2
2013	1	0	1
2014	1	0	1
2015	0	1	1
2016	1	0	1
2025	1	0	1

Below are the most recent publications written about "Interleukin-5" by people in Profiles.

Sciurba FC, Criner GJ, Christenson SA, Martinez FJ, Papi A, Roche N, Bourbeau J, Korn S, Bafadhel M, Han MK, Kolterer S, Miller K, Mouneimne D, Fletcher J, Mayer B, Min J, Pavord ID. Mepolizumab to Prevent Exacerbations of COPD with an Eosinophilic Phenotype. N Engl J Med. 2025 May 01; 392(17):1710-1720.

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Jarjour NN, Bradstreet TR, Schwarzkopf EA, Cook ME, Lai CW, Huang SC, Taneja R, Stappenbeck TS, Van Dyken SJ, Urban JF, Edelson BT. BHLHE40 Promotes TH2 Cell-Mediated Antihelminth Immunity and Reveals Cooperative CSF2RB Family Cytokines. J Immunol. 2020 02 15; 204(4):923-932.

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Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5. J Immunol. 2016 06 15; 196(12):4957-66.

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Nobles C, Bertone-Johnson ER, Ronnenberg AG, Faraj JM, Zagarins S, Takashima-Uebelhoer BB, Whitcomb BW. Correlation of urine and plasma cytokine levels among reproductive-aged women. Eur J Clin Invest. 2015 May; 45(5):460-5.

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Haldar P, Brightling CE, Singapuri A, Hargadon B, Gupta S, Monteiro W, Bradding P, Green RH, Wardlaw AJ, Ortega H, Pavord ID. Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis. J Allergy Clin Immunol. 2014 Mar; 133(3):921-3.

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Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med. 2013 Sep 15; 188(6):657-63.

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Lu S. Gene-based adjuvants: a new meaning. Hum Gene Ther. 2009 Oct; 20(10):1101-2.

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Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, Marshall RP, Bradding P, Green RH, Wardlaw AJ, Pavord ID. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009 Mar 05; 360(10):973-84.

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Zhu FG, Kandimalla ER, Yu D, Agrawal S. Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice. J Allergy Clin Immunol. 2007 Sep; 120(3):631-7.

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Kaminski DA, Stavnezer J. Stimuli that enhance IgA class switching increase histone 3 acetylation at S alpha, but poorly stimulate sequential switching from IgG2b. Eur J Immunol. 2007 Jan; 37(1):240-51.

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