"Genes, Retinoblastoma" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Tumor suppressor genes located on human chromosome 13 in the region 13q14 and coding for a family of phosphoproteins with molecular weights ranging from 104 kDa to 115 kDa. One copy of the wild-type Rb gene is necessary for normal retinal development. Loss or inactivation of both alleles at this locus results in retinoblastoma.
| Descriptor ID |
D016161
|
| MeSH Number(s) |
G05.360.340.024.340.375.249.400 G05.360.340.024.340.415.400.400
|
| Concept/Terms |
Genes, Retinoblastoma- Genes, Retinoblastoma
- Rb Genes
- Retinoblastoma Genes
- Gene, Retinoblastoma
- Retinoblastoma Gene
- Genes, Rb
- Gene, Rb
- Rb Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, Retinoblastoma".
Below are MeSH descriptors whose meaning is more specific than "Genes, Retinoblastoma".
This graph shows the total number of publications written about "Genes, Retinoblastoma" by people in this website by year, and whether "Genes, Retinoblastoma" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Genes, Retinoblastoma" by people in Profiles.
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Little MP, Schaeffer ML, Reulen RC, Abramson DH, Stovall M, Weathers R, de Vathaire F, Diallo I, Seddon JM, Hawkins MM, Tucker MA, Kleinerman RA. Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study. Br J Cancer. 2014 May 13; 110(10):2623-32.
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Pickering MT, Kowalik TF. Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. Oncogene. 2006 Feb 02; 25(5):746-55.
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Matsui JI, Parker MA, Ryals BM, Cotanche DA. Regeneration and replacement in the vertebrate inner ear. Drug Discov Today. 2005 Oct 01; 10(19):1307-12.
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Simin K, Hill R, Song Y, Zhang Q, Bash R, Cardiff RD, Yin C, Xiao A, McCarthy K, van Dyke T. Deciphering cancer complexities in genetically engineered mice. Cold Spring Harb Symp Quant Biol. 2005; 70:283-90.
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Simin K, Wu H, Lu L, Pinkel D, Albertson D, Cardiff RD, Van Dyke T. pRb inactivation in mammary cells reveals common mechanisms for tumor initiation and progression in divergent epithelia. PLoS Biol. 2004 Feb; 2(2):E22.